A cerium nanocluster for effective alleviation of inflammatory bowel disease by scavenging RONS and regulating gut microbiome [0.03%]
一种用于有效缓解炎症性肠病的铈基纳米团簇及其机理研究
Dan Yang,Rong Wang,Lei Zhao et al.
Dan Yang et al.
Inflammatory bowel disease (IBD) is characterized by excessive generation of reactive oxygen species and reactive nitrogen species (RONS) within the pro-inflammatory microenvironment. Conventional treatments often have serious side effects,...
Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity [0.03%]
异硫氰酸翼瓣菊酯功能化超小纳米颗粒调节补体途径抑制小胶质细胞突触吞噬作用以减少麻醉神经毒性
Gang Wang,Yaobao Han,Ke Peng et al.
Gang Wang et al.
Synaptic impairment is identified as a primary pathology in sevoflurane-induced neurotoxicity, contributing to neurobehavioral and neurodevelopmental deficits. Synaptic loss in neurons occurs through microglia-mediated synaptic phagocytosis...
Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy [0.03%]
通过级联限制疗法和化学动力学疗法降低内源性铜和葡萄糖的可用性
Chunhui Wang,Pingting Ye,Mengyao Chen et al.
Chunhui Wang et al.
The rapid growth of tumors relies heavily on a continuous supply of essential nutrients, including glucose and copper. Disrupting the nutrient supply to tumors has become an increasingly focal point in tumor therapy. However, solely blockin...
Metal-organic framework-based delivery systems as nanovaccine for enhancing immunity against porcine circovirus type 2 [0.03%]
基于金属有机骨架的递送系统作为纳米疫苗增强猪圆环病毒病免疫效力
Luo-Gang Ding,Min Shi,Er-Di Yu et al.
Luo-Gang Ding et al.
Porcine circovirus type 2 (PCV2) has caused massive economic losses to the global pig farming industry. As emerging nanomaterials, metal-organic frameworks (MOFs) have considerable potential in drug and vaccine delivery because of their uni...
Improved pleiotropic antibacterial activity of Ag(I)-Thiolate coordination polymers via iodide encapsulation in multinuclear silver nano cages [0.03%]
通过碘化物封装在多核银纳米笼中改进硫醇盐配位聚合物的多功能抗菌活性
Chunhong Tan,Menghan Lu,Tao Zhou et al.
Chunhong Tan et al.
Silver-based nanomaterials have attracted considerable attention due to their antimicrobial properties. In this study, two nano-AgI-cage-based coordination polymers, [Ag6(μ-StBu)6]n (University of South China Coordination Polymer USC-CP-2)...
Artificial intelligence-assisted magnetic resonance lymphography for evaluation of micro- and macro-sentinel lymph node metastasis in breast cancer [0.03%]
乳腺癌患者微淋巴结和巨淋巴结转移的磁共振淋巴造影评估的人工智能辅助研究
Zizhen Yang,Jianer Ling,Wei Sun et al.
Zizhen Yang et al.
Contrast-enhanced magnetic resonance lymphography (CE-MRL) plays a crucial role in preoperative diagnostic for evaluating tumor metastatic sentinel lymph node (T-SLN), by integrating detailed lymphatic information about lymphatic anatomy an...
Engineering a dynamic extracellular matrix using thrombospondin-1 to propel hepatocyte organoids reprogramming and improve mouse liver regeneration post-transplantation [0.03%]
工程化动态细胞外基质以促进肝细胞类器官重编程并提高移植后小鼠肝脏再生效果
Zi-Yan Xu,Min Wang,Jing-Yan Shi et al.
Zi-Yan Xu et al.
Hepatocyte organoids (HOs) hold significant potential for constructing bioartificial liver construction, toxicology research, and liver failure therapies. However, challenges such as difficulties in induced pluripotent stem cells (iPSCs) ha...
A triple-mode strategy on JQ1-loaded nanoplatform for superior antitumor therapy in pancreatic cancer [0.03%]
用于胰腺癌的JQ1负载型纳米平台的三模式策略以实现优异的抗肿瘤治疗效果
Zhiguo Li,Jinxin Duan,Zhiwen Liu et al.
Zhiguo Li et al.
Pancreatic cancer's dire prognosis urgently calls for innovative therapeutic strategies. JQ1, a bromodomain 4 inhibitor, exhibits potent anti-tumor activity in preclinical models but faces limitations due to rapid resistance development. He...
Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma [0.03%]
一种免疫细胞靶向介导的类机体药物递送系统用于原位胶质瘤治疗中的血脑屏障渗透及精准治疗
Xiu Wang,Baoqin Song,Mengru Wu et al.
Xiu Wang et al.
Gliomas are a group of highly malignant tumors that are prone to recurrence after surgery. Due to the limitation of the blood-brain barrier (BBB), most antitumor drugs cannot cross it. Therefore, improving the delivery efficiency of antitum...
Peptide loaded self-healing hydrogel promotes diabetic skin wound healing through macrophage orchestration and inflammation inhibition [0.03%]
肽类负载的自修复水凝胶通过巨噬细胞调控和抑制炎症促进糖尿病皮肤伤口愈合
Ziyi Lu,Kaijia Tan,Shuwen Xiang et al.
Ziyi Lu et al.
Chronic wound is one of the complications of diabetes, and its difficult cure results in increased disability rate and mortality rate, which brings serious psychological and economic burden to patients. Excessive inflammation is one of the ...