Qing Yao,Yannan Shi,Yinsha Yao et al.
Qing Yao et al.
In situ forming hydrogels (ISFGs) have emerged as a promising platform for localized drug delivery in colorectal cancer (CRC) therapy, addressing limitations of systemic treatments such as off-target toxicity and poor drug accumulation at t...
Glycolysis inhibition via pH-responsive nanoparticles modulates macrophage reprogramming for sepsis immunotherapy [0.03%]
基于pH响应型纳米粒的糖酵解抑制调控巨噬细胞重编程以治疗脓毒症免疫紊乱
Ni Ding,Jinyan Guo,Zhenjia Lin et al.
Ni Ding et al.
Sepsis persists as a life-threatening clinical syndrome associated with alarmingly high mortality rates, while existing therapeutic strategies demonstrate suboptimal efficacy, necessitating the development of novel interventions. In this st...
Orally administered gallic acid nanoparticles adhere to intestine via in-situ gelation for enhanced UC treatment [0.03%]
口服没食子酸纳米颗粒通过原位凝胶化粘附于肠黏膜以增强溃疡性结肠炎的治疗效果
Huan Chen,Jixiang Zhao,Zhuo Li et al.
Huan Chen et al.
The increasing incidence of intractable ulcerative colitis (UC) necessitates the development of targeted therapeutics. Herein, we developed a gallic acid (GA)-based nanoparticle that forms a hydrogel with GA-functionalized pectin (PG) in si...
Banghui Wang,Tao Chen,Yixuan Li et al.
Banghui Wang et al.
Janus nanomotors (JNMs), as a forefront nanotechnology research focus, demonstrate great potential due to their special asymmetric structure and outstanding performance in disease diagnosis and treatment. These "two-faced" nanoparticles exh...
Symmetry breaking unlocks superior reactivity in single atom catalytic therapy [0.03%]
symmetry broken!单原子催化治疗中破缺对称性解锁优异反应性
Chenyu Ding,Chengzhong Du,Penghui Wei et al.
Chenyu Ding et al.
Single atom enzymes (SAEs) serve as promising alternatives to natural enzymes in therapeutic applications due to their simple structure and strong catalytic performance. However, their activity often lags native enzymes, limiting their prac...
Polydopamine-chitosan coated biofilm-state Lacticaseibacillus paracasei SB27 as a living band-aid for targeted colitis therapy [0.03%]
聚多巴胺-壳聚糖包被的生物膜状植物乳杆菌SB27作为针对结肠炎治疗的活性创可贴
Yinxue Liu,Yisuo Liu,Lu Jiang et al.
Yinxue Liu et al.
Inflammatory bowel disease (IBD) involves chronic intestinal inflammation and epithelial barrier disruption. While probiotics offer therapeutic potential, planktonic (PLA) forms suffer from poor viability, limited adhesion, and suboptimal e...
Modulating the crystallinity of biphasic calcium phosphate composites balances surface and ionic cues to enhance osteogenesis via integrin-mediated cytoskeletal signaling [0.03%]
调控双相钙磷酸盐复合材料的结晶度可平衡表面和离子信号以通过整合素介导的细胞骨架信号传导增强成骨作用
Xinzhi Liang,Shuai Yuan,Ning Zhang et al.
Xinzhi Liang et al.
Biphasic calcium phosphate (BCP) composites are widely employed for bone repair, with osteogenic performance governed by both the HA:β-TCP ratio and crystallinity. While compositional tuning has been extensively investigated, the role of c...
Probiotic-based self-crosslinking bio-coating for the treatment of colitis by increasing probiotic colonization [0.03%]
一种基于益生菌的自交联生物涂层通过增加益生菌定植来治疗结肠炎
Shang Shi,Boqing Li,Ying Zhang et al.
Shang Shi et al.
Probiotic-based therapies have great potential to treat inflammatory bowel disease (IBD). Still, their success is limited by difficulties in ensuring survival, colonization, and targeted effects within the harsh environment of the gastroint...
Nanodelivery of panobinostat induces cell cycle arrest and apoptosis to suppress hepatocellular carcinoma growth in mice [0.03%]
纳米载药递送帕尼单抗可诱导肝癌细胞周期停止和凋亡以抑制其在小鼠体内的生长
Yutong Li,Dong Li,Junjun Chen et al.
Yutong Li et al.
Hepatocellular carcinoma (HCC), the predominant subtype of primary liver cancer, remains as a globally lethal malignancy with limited therapeutic options. Despite therapeutic efficacy of small-molecule inhibitors, the majority of HCC patien...
Robust and ultra-stable nanohesive-based solid-like slippery coating under dynamic blood flow environment for durable prevention of thrombosis and biofouling [0.03%]
一种耐久的防血栓和生物污染涂层，在动态血液环境中具有鲁棒性且极其稳定的纳米粘合剂类固态滑动涂层
Shu Zhang,Jihua Zou,Yupeng Xiao et al.
Shu Zhang et al.
Biomedical devices face thrombosis and infection risks due to nonspecific bioadhesion. Although liquid-infused surfaces (LIS) exhibit anti-biofouling potential, lubricant loss under blood flow limits their utility. An innovative "solid-like...