Self-assembled nanoparticles from natural herbs alleviate osteoarthritis by targeting retinol metabolism and inhibiting chondrocyte ferroptosis [0.03%]
来源于天然草本的自组装纳米颗粒通过靶向维生素A代谢及抑制软骨细胞铁死亡来缓解骨关节炎
Xuefeng Li,Yuhang Wang,Xucheng Wang et al.
Xuefeng Li et al.
Osteoarthritis (OA), a prevalent degenerative joint disease, currently lacks effective therapies. Self-assembled nanomedicines derived from herbs create innovative pharmaceutical formulations, and offer promising therapeutic strategies for ...
Nanoadjuvant-integrated organic biomaterials for immune engineering: Mechanisms, design strategies, and translational applications [0.03%]
纳米辅助型有机生物材料在免疫工程中的应用：机制、设计策略及转化应用
Shi Tang,Ling Lv,Na Liu et al.
Shi Tang et al.
Immune enhancement is a central objective in modern immunotherapy, vaccination, and regenerative medicine; however, achieving a powerful, sustained immune response while reducing overall systemic toxicity remains a major challenge. Organic ...
Cardiac-homing peptide-targeted colchicine-based drugstores with inhibiting inflammatory response for myocardial infarction improvement [0.03%]
一种基于秋水仙碱的心肌梗死治疗型心脏病灶靶向药物释放库微针系统
Xing Zhang,Wenhua Xu,Jie Song et al.
Xing Zhang et al.
One of the primary challenges in addressing cardiac injury is the limited cardiac specificity of therapeutic drugs. Lipid nanoparticles (LNPs) are a relatively novel class of delivery vehicles used for administering RNA and various drugs. A...
A sequential and synergistic release sacrificial microgels scaffold for endometrial niche reprogramming and fertility restoration [0.03%]
一种序贯协同释放的微凝胶支架用于子宫内膜生态位重建和恢复生育力
Qian Liu,Shun Lu,Junhua Zhou et al.
Qian Liu et al.
Intrauterine adhesions (IUA) remain a therapeutic challenge, necessitating advanced regenerative strategies. Herein, we propose a "programmed endometrial niche" strategy, a 3D-printed adipose-derived stem cells (ADSCs) hydrogel scaffold is ...
Two-step distance tuning of T1-T2 dual-activated magnetic resonance nanoprobe for enhanced tumor diagnosis [0.03%]
两步距离调谐T1-T2双激活磁共振纳米探针以增强肿瘤诊断
Yuxing He,Nengyi Ni,Mengmeng Zhang et al.
Yuxing He et al.
When traditional T1 and T2 contrast agents coexist, the magnetic coupling effect leads to signal interference, which severely limits the synergistic enhancement potential of dual-mode magnetic resonance imaging (MRI). In this study, we intr...
Engineering anisotropic tissues: from structured scaffolds to magnetic actuation [0.03%]
工程各向异性组织：从结构支架到磁驱动
Noam Demri,Stéphanie Descroix,Claire Wilhelm
Noam Demri
Tissue engineering emerged in the late 20th century to replicate human tissues in vitro for biomedical applications. Early concepts relied on culturing cells within three-dimensional scaffolds to reproduce in vivo architecture. However, nat...
NIR-II-triggered copper single-atom catalyst depots coupling catalysis and drug release for infected chronic wounds with dysregulated inflammation [0.03%]
近红外触发的铜单原子催化剂库结合催化和药物释放治疗感染的慢性伤口失调炎症
Mingqian Wang,Jiamu Xiao,Songjie Han et al.
Mingqian Wang et al.
Precise control of antimicrobial and immunomodulatory signals in both space and time is essential for addressing drug-resistant chronic wounds. Here, an NIR-II-responsive nanomedicine depot is created by integrating fasudil (FAS) into a cop...
An immunomodulatory bioactive glass orchestrates early bone healing via coordinated macrophage polarization and osteogenesis-osteolysis balance [0.03%]
一种免疫调节生物活性玻璃通过协调巨噬细胞极化和骨形成-骨吸收平衡来促进早期骨折愈合
Xueying Li,Jilin Wu,Jingyi Li et al.
Xueying Li et al.
Effective repair of large bone defects remains a major challenge in regenerative medicine. Conventional strategies often emphasize enhancing osteogenesis, while the role of the early immune microenvironment remains insufficiently addressed....
Hierarchical piezoelectric conduit coordinates bioelectric cues and microRNA regulation for functional neurological regeneration [0.03%]
分层压电导管协调生物电信号和微小RNA调节以实现神经功能再生
Sirui Liu,Lin Song,Xueyan Zhang et al.
Sirui Liu et al.
Current clinical interventions for critical-sized nerve defects face dual challenges of inadequate microenvironmental guidance and passive regenerative response in synthetic neural interfaces. We present an electrotopographic nerve guidance...
Recent advances in nanocellulose scaffold membranes: Sources, processing and functionalization [0.03%]
纳米纤维素支架膜的最新进展：来源、加工和功能化
Hanyuan Chen,Yanqun Huang,Feng Wang et al.
Hanyuan Chen et al.
Nanocellulose, derived from renewable cellulose resources, has emerged as a highly promising candidate for biomedical scaffold membrane applications owing to its excellent mechanical properties, tunable surface chemistry, biodegradability, ...