Redirecting the route: Monocyte-mediated delivery of oHSV-1 across a human BBB-on-chip model [0.03%]
基于人类血脑屏障芯片模型的单核细胞介导oHSV-1递送研究
Sara Micheli,Alberto Reale,Alessandra Rossetto et al.
Sara Micheli et al.
Oncolytic viruses (OVs) that selectively replicate within cancer cells represent a promising therapeutic strategy for refractory or difficult-to-treat tumors such as Glioblastoma (GBM). In this study, we develop and validate a human microfl...
4'-hydroxychalcone nanofiber hydrogel dressing promotes diabetic chronic wound healing by regulating macrophage polarization via the TLR/IL-17/TNF signaling pathway [0.03%]
4'-羟基查尔酮纳米纤维水凝胶敷料通过调节 toll 样受体 / 白细胞介素 -17/ 肿瘤坏死因子信号通路促进糖尿病慢性伤口愈合
Hong-Yang Li,Mi-Yang Li,Chuan-Xin Cui et al.
Hong-Yang Li et al.
Background: The activation and polarization of macrophages play a crucial role in the inflammatory response in chronic diabetic wound healing. Modulating macrophage polarization toward the M2 phenotype can facilitate woun...
Attenuation of blood-brain barrier dysfunction by functionalized gold nanoparticles against amyloid-β peptide in an Alzheimer's disease-on-a-chip model [0.03%]
功能性金纳米颗粒通过阿尔茨海默病芯片模型削弱淀粉样蛋白-β肽引起的血脑屏障功能障碍
Andreas Arellano,Sujey Palma-Florez,Pablo Cabrera et al.
Andreas Arellano et al.
Gold nanoparticles (GNP) are highly valuable in nanotechnology due to their biocompatibility and unique physicochemical properties, which make them attractive as nanocarriers for targeted drug delivery. In the context of neurodegenerative d...
Polyethyleneimine-modified Laminarin nanoparticles enhance antigen delivery to lymph nodes by inducing transient inflammatory responses at the injection site [0.03%]
聚乙二胺修饰的 laminarin 纳米粒子通过在注射部位诱导短暂炎症反应来增强将抗原递送至淋巴结的能力
Ruihong Yu,Lulu Zhang,Zuchen Song et al.
Ruihong Yu et al.
Functionalized nanoparticles hold great potential as vaccine adjuvants. In our previous study, we demonstrated that polyethyleneimine-modified Laminarin nanoparticles (CLam/OVA) exhibit potent adjuvant effects. However, it is still unclear ...
The novel hydrogen-PT2385-silncARSR nanocomplex impairs tumor angiogenesis and mitochondrial activity in sunitinib-resistant renal cancer [0.03%]
新型的氢-PT2385-沉默ARSR纳米复合物可抑制舒尼替尼耐药肾癌的肿瘤血管生成和线粒体活性
Suxian Hu,Yan Zhu,Yi Duan et al.
Suxian Hu et al.
Hydrogen therapy has emerged as a promising agent for cancer treatment. Earlier research demonstrated that hydrogen (H2) possesses anti-angiogenic effects across multiple tumor types. However, no studies have yet investigated the anti-angio...
The drug discovery and therapeutic nano-strategies targeting cellular senescence [0.03%]
针对细胞衰老的药物发现和治疗纳米策略
Yumei Wang,Mingqi Liu,Xinzhao Chen et al.
Yumei Wang et al.
Cellular senescence is a primary driver of aging, where damaged or senescent cells (SnCs) continuously accumulate in the body, altering the local tissue environment and causing various pathologies in different organs or tissues, offering br...
M1 macrophage-targeted glucose-functionalized nanoparticles for berberine delivery and inflammatory microenvironment remodeling in osteoarthritis therapy [0.03%]
用于骨关节炎治疗的针对M1型巨噬细胞的葡萄糖功能化载小檗碱纳米颗粒及重塑炎症微环境
Weibei Sheng,Lin Li,Zimeng Zhou et al.
Weibei Sheng et al.
The inflammatory microenvironment mediated by synovial macrophages, particularly the pro-inflammatory M1 subtype, plays a central role in OA progression and represents a critical therapeutic target. However, delivery strategies that enable ...
EUK nanozyme-loaded PL&GA coacervate droplets attenuate ulcerative colitis through restoring gut homeostasis and restricting intestinal cell ferroptosis [0.03%]
负载EUK纳米酶的PL和GA共沉淀液滴通过恢复肠道稳态和限制肠细胞铁死亡来缓解溃疡性结肠炎
Mingxia Zhou,Linping Lu,Xinyu Xu et al.
Mingxia Zhou et al.
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), manifests as chronic diarrhea, abdominal pain, and bloody mucoid stools. Current treatment approaches for UC are typically limited by inadequate targeted deliver...
Chitosan nanoparticles: Green synthesis, biological activities, and sustainable frontiers in targeted drug delivery and cancer nanomedicine - A comprehensive review [0.03%]
壳聚糖纳米颗粒：绿色合成、生物活性及可持续性在靶向药物递送和癌症纳米医学中的前沿研究-全面综述
Mohamed T El-Saadony,Ahmed M Saad,Mahmoud Sitohy et al.
Mohamed T El-Saadony et al.
Chitosan, a biopolymer derived from chitin-the second most abundant natural polysaccharide found in crustaceans such as crabs, lobsters, and shrimp-has become a cornerstone in biomedical innovation. Its unique properties, including hydrophi...
Harnessing light: Synthesis, mechanisms, and pre-clinical biomedical applications of stimuli-responsive multiscale composites [0.03%]
基于刺激响应的多层次复合材料的合成、机理及生物医学应用研究进展
Sandip Ghosh,Chia-Jung Yang,Jui-Yang Lai
Sandip Ghosh
Smart multiscale composites with stimuli-responsive versatility have significantly advanced the field of biomedical science by providing precise spatiotemporal control over modulating, diagnostic, and therapeutic functions. Light-responsive...