Engineered skin commensal nanogels mitigate psoriasiform inflammation through dual regulation of cutaneous flora and host immunity [0.03%]
仿生工程菌群纳米凝胶通过双重调节皮肤菌群和宿主免疫减轻银屑病炎症
Yang Lv,Jinxiao Li,Zicong Xu et al.
Yang Lv et al.
Psoriasis is a chronic inflammatory skin disorder characterized by immune dysregulation and alterations in the cutaneous microbiota. Current microbiome-targeted therapeutic strategies predominantly involve the topical delivery of live probi...
Source-level motion artifact suppression in wearable electrodes: From underlying mechanisms to advanced strategies [0.03%]
可穿戴电极中的源级运动伪迹抑制：从基本原理到先进策略
Haizhou Huang,Xuanjing Cai,Shu Wan et al.
Haizhou Huang et al.
Motion artifacts (MAs) significantly degrade the quality of surface biopotential signals acquired in dynamic environments (such as during body movements), severely compromising their reliable application in health monitoring and disease dia...
Calcium peroxide loaded liposomes reprogram hypoxic and acidic tumor microenvironment to overcome lenvatinib resistance in hepatocellular carcinoma [0.03%]
载有过氧化钙的脂质体可重编程肝癌中低氧和酸性肿瘤微环境以克服仑伐替尼耐药性
Yaowei Bai,Xiaoye Li,Yu Lei et al.
Yaowei Bai et al.
Background: Lenvatinib resistance severely limits the therapeutic efficacy in advanced hepatocellular carcinoma and is increasingly recognized as a systemic adaptive state driven by the hypoxic and acidic tumor microenvir...
SynClear: A one-step synchronous clearing and labeling strategy for multiscale 3D brain mapping [0.03%]
同步清除和标记的多尺度三维脑图谱的一步法研究（SynClear）
Xiao Xiao,Canyu Ma,Yashuo Wang et al.
Xiao Xiao et al.
High-resolution three-dimensional imaging is essential for resolving the multiscale organization of biological tissues. However, conventional workflows treat tissue clearing and molecular labeling as separate steps, leading to a kinetic mis...
Epicardial extracellular vesicles modulate gene expression following ischemia-reperfusion injury in heart-on-a-chip [0.03%]
epicardial外泌体在心脏芯片缺血再灌注损伤后的基因表达调控作用
Karl T Wagner,Dawn Bannerman,Qinghua Wu et al.
Karl T Wagner et al.
The epicardium is an essential regulator of cardiac development, homeostasis, and injury, yet the composition and impacts of epicardial cell-secreted extracellular vesicles (EVs) remain incompletely understood. Here, we harness an epicardia...
Provoking disulfidptosis-enhanced mitophagy by manganese-based nanoplatform via regulating cellular energy supply and redox homeostasis [0.03%]
基于锰的纳米平台通过调节细胞能量供应和氧化还原稳态诱发半胱氨酸蛋白酶介导的线粒体自噬
Zhenying Diao,Bin Feng,Yanfei Fu et al.
Zhenying Diao et al.
Metabolic reprogramming and reinforcing redox defense mechanisms in tumors remains major obstacles to oxidative stress therapies in Non-small cell lung cancer (NSCLC). To address these obstacles, we strategically targeted cystine transporte...
Precision nanomedicine for lung metastatic osteosarcoma: challenges, therapeutic strategies, and perspectives [0.03%]
精准纳米医学在肺转移性骨肉瘤中的应用：挑战、治疗策略和前景展望
Haozheng Li,Jing Luo,Qianli Wang et al.
Haozheng Li et al.
Lung metastatic osteosarcoma (LM-OS) remains the leading cause of mortality in patients with osteosarcoma and is poorly controlled by current therapeutic regimens. The limited efficacy of conventional treatments is closely related to the co...
A comprehensive review of mitochondrial fluorescent probes: Design principles, fluorophore engineering, and functional parameter sensing [0.03%]
全面综述线粒体荧光探针：设计原理、荧光团工程和功能参数感应
Fei Peng,Bo Wang,Ran Chai et al.
Fei Peng et al.
Mitochondria are essential organelles that play pivotal roles in cellular energy metabolism, signaling, and homeostasis, and their dysfunction is closely associated with various human diseases. In recent years, the rapid development of mito...
Molecularly self-assembled nanoplatforms for targeted ROS-scavenging and neuroinflammation alleviation in acute ischemic stroke [0.03%]
急性缺血性脑卒中分子自组装纳米平台靶向清除ROS和消炎抗氧化治疗
Xianru Bi,Meng He,Wenxuan Cao et al.
Xianru Bi et al.
Cerebral ischemia-reperfusion injury (CIRI) poses a pivotal barrier to neuronal survival after successful recanalization in acute ischemic stroke. This phenomenon involves multiplexed pathophysiology where oxidative stress-neuroinflammation...
Medical dressing inspired by dandelion "smashed for external application" therapy for diabetic wound care [0.03%]
一种用于糖尿病伤口护理的蒲公英"捣烂外敷"治疗灵感的医疗绷带
Shenyu Tan,Xi Luo,Shujia Yao et al.
Shenyu Tan et al.
Developing bioactive dressings to remodel pathological microenvironments is critical for diabetic foot ulcer management. Drawing inspiration from the traditional "smashed for external application" of Taraxacum mongolicum Hand.-Mazz., a biom...