A manganese-luteolin co-loaded antioxidant hydrogel for synergistic alleviation of oxidative stress and immunomodulation in intervertebral disc degeneration [0.03%]
一种抗氧化性凝胶，可协同缓解氧化应激和免疫调节治疗椎间盘退变
Yaohong Wu,Qin Chen,Mingliang Zhong et al.
Yaohong Wu et al.
Intervertebral disc degeneration (IVDD) is a multifactorial degenerative disorder primarily driven by oxidative stress, chronic inflammation, and progressive extracellular matrix (ECM) breakdown. Current therapeutic approaches largely aim t...
A sustained-release depot formulation of β-nicotinamide mononucleotide for alleviating chemotherapy-induced myelosuppression [0.03%]
一种β-烟酰胺单核苷酸长效缓释制剂用于缓解化疗引起的骨髓抑制作用
Bin Yu,Yuxian Lin,Xuecun Liu et al.
Bin Yu et al.
Chemotherapy-induced myelosuppression (CIM) is characterized by impaired hematopoietic function and a sharp decline in peripheral blood cell counts. To address this issue, we developed a sustained-release depot microsphere formulation to de...
Recent advances in nanomaterial-based strategies for chronic pain alleviation [0.03%]
基于纳米材料的慢性疼痛缓解策略的研究进展
Zihan Xue,Chengfeng Zhang,Jingyi Wang et al.
Zihan Xue et al.
Chronic pain profoundly impacts global quality of life, positioning effective pain management as a critical medical priority. Currently, clinical pain treatment relies heavily on non-steroidal anti-inflammatory drugs and opioids, which, how...
A renally clearable tumor-targeted probe enabling functional delineation of tumor margins by NIR-II fluorescence lifetime imaging [0.03%]
一种可经肾脏清除的肿瘤靶向探针通过近红外二区荧光寿命成像实现肿瘤边缘的功能性界定
Jin Zhang,Jiuling Liao,Dong Han et al.
Jin Zhang et al.
Accurate intraoperative delineation of tumor margins remains a major clinical challenge because conventional fluorescence imaging is strongly influenced by probe concentration, tissue heterogeneity, and imaging conditions. Here, we report a...
Synovial macrophage-targeted hierarchical microspheres achieve cartilage preservation and pain relief in osteoarthritis [0.03%]
滑膜巨噬细胞靶向的分层微球实现骨关节炎软骨保护和镇痛
Guojiang Zhang,Laibo Zhang,Xiangdong Wen et al.
Guojiang Zhang et al.
Pain, the hallmark symptom of osteoarthritis (OA), drives most patients to seek medical care. The current analgesics only provide partial pain relief, while fail to modify disease progression and introduce adverse effects with long-term use...
Core-shell microneedles Co-loaded with simvastatin and doxycycline for combined anti-infection and osteogenesis in diabetic periodontitis [0.03%]
西立伐他汀和多西环素共负载核心-壳缓释微针联合防治糖尿病型牙周炎感染及促骨再生治疗的功效研究
Shengdan Zhang,Wen Zhang,You Wang et al.
Shengdan Zhang et al.
Diabetic periodontitis remains a formidable clinical challenge characterized by persistent infection, oxidative stress, and impaired alveolar bone regeneration. Here, we have developed an engineered core-shell microneedle (MN) patch that en...
A ROS-responsive "one-two punch" nanozyme for self-supplying oxygen and suppressing immune rejection in heart transplantation [0.03%]
一种ROS响应的“一石二鸟”型纳米酶，在心脏移植中可自供氧和抑制免疫排斥反应
Zhaohua Yang,Shutian Zhang,Wenrui Ma et al.
Zhaohua Yang et al.
Heart transplantation offers the only life-saving option for patients with terminal heart failure; yet, the sequential "innate-adaptive" avalanche initiated by ischemia-reperfusion injury (IRI) remains the Achilles' heel of long-term graft ...
A Janus polydopamine nanomotor hydrogel enables enhanced tumor penetration and potent synergistic photothermal-photodynamic therapy [0.03%]
Janus聚多巴胺纳米发动机水凝胶增强肿瘤渗透和高效的光热-光动力协同治疗
Jiahui Jiang,Yangbo Lv,Mengyuan Ma et al.
Jiahui Jiang et al.
Hydrogels are widely recognized as promising carriers for antitumor drug delivery owing to their tunable physicochemical properties. However, elevated interstitial fluid pressure and a dense extracellular matrix within tumors often restrict...
AI-enabled label free monitoring of TGFβ1-induced remodeling in iPSC-derived alveolar organoids [0.03%]
基于人工智能的TGFβ1诱导的肺泡类器官重塑监测技术
Seung Hyeon Kim,Jooyeon Lee,Jong Hyeok Han et al.
Seung Hyeon Kim et al.
Pulmonary fibrosis (PF) is a progressive interstitial lung disease with poor prognosis and limited therapeutic options, largely due to the lack of physiologically relevant and dynamically traceable preclinical models. Here, we establish an ...
Edaravone-based precision antioxidative therapy alleviates intervertebral disc degeneration via the Nrf2/Aldh3a1 axis [0.03%]
以艾地苯为基础的精准抗氧化治疗通过Nrf2/Aldh3a1轴缓解椎间盘退变
Yuhang Gong,Xinyu Wu,Zhiyu Fang et al.
Yuhang Gong et al.
Oxidative stress-induced dysfunction of nucleus pulposus (NP) cells is a key driver of intervertebral disc degeneration (IDD), promoting accelerated cellular senescence and extracellular matrix (ECM) degradation. Moreover, effective regulat...