Rational design of a V-shaped DNA-targeted photosensitizer enables endogenous DNA damage-driven cGAS-STING activation and systemic antitumor immunity [0.03%]
V形DNA靶向光敏剂的理性设计实现内源性DNA损伤驱动的cGAS-STING活化和全身抗肿瘤免疫响应
Yi Cai,Cai-Yun Wang,Min Dong et al.
Yi Cai et al.
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is a central driver of antitumor immunity, yet its safe and efficient activation in solid tumors remains challenging. Here we report a V-shaped photosensitizer,...
An integrated nano-delivery platform via baicalein-loaded polydopamine-MOF for enhanced neuroprotection against retinal ischemia reperfusion injury [0.03%]
一种通过负载鼠尾草酚的聚多巴胺金属有机骨架材料用于视网膜缺血再灌注损伤神经保护的纳米递送平台
Xin Liu,Keke Huang,Zhiqing Lin et al.
Xin Liu et al.
Retinal ischemia reperfusion injury (RIRI) presents a complex pathological mechanism involving oxidative stress, neuroinflammation, and retinal ganglion cell (RGC) apoptosis, with current therapies limited by their inability to address thes...
3D HucMSCs derived extracellular vesicles enhanced therapeutic efficacy in treating intrauterine adhesions via BECN1 delivery [0.03%]
人子宫内膜间充质干细胞源外泌体通过携带BECN1蛋白治疗宫腔粘连的作用及机制研究
Juan Peng,Juan Zhang,Qingzhao Li et al.
Juan Peng et al.
Intrauterine adhesion (IUA) is a significant cause of female infertility and a critical public health concern among women of childbearing age. Emerging evidence has highlighted the therapeutic potential of mesenchymal stem cell-derived extr...
Nanoscale delivery systems for hepatocellular carcinoma: Functionalization, delivery strategies, and clinical challenges [0.03%]
肝细胞癌纳米给药系统：功能化、传输策略与临床挑战
Zhuoya Fu,Bingzhu Zheng,Jiawei Zhang et al.
Zhuoya Fu et al.
Hepatocellular carcinoma (HCC) remains a leading driver of cancer-related mortality, characterized by profound heterogeneity and a formidable Tumor microenvironment (TME). Conventional therapeutic interventions, including traditional chemot...
Diselenide-bridged mesoporous silica nanoplatform for baicalin delivery facilitates spinal cord injury repair via CHCHD2-mediated mitochondrial homeostasis restoration [0.03%]
硒桥介导的固有二氧化硅纳米平台通过载入黄酮类化合物 Baicalin 促进脊髓损伤修复：一种新的分子机制(CHCHD2)
Yongchun Xiao,Guang Tang,Zhiwan Chen et al.
Yongchun Xiao et al.
During the secondary phase of spinal cord injury (SCI), excessive accumulation of reactive oxygen species (ROS), mitochondrial dysfunction and amplified inflammatory cascades reinforce one another, forming a vicious cycle that drives progre...
Enhanced ocular delivery of tacrolimus via cationic nanoliposomes: Mitigating inflammation and rebalancing Th17/Treg responses in dry eye disease [0.03%]
通过阳离子纳米脂质体增强他克莫司眼部递送：缓解干眼病炎症和重塑Th17/Treg平衡
Lirui Liu,Dan Chen,Siting Sheng et al.
Lirui Liu et al.
Dry eye disease (DED) is a common ocular surface disorder characterized by persistent inflammation and immune imbalance, leading to visual impairment and substantial deterioration in quality of life. Although topical medications remain the ...
Fluorinated charge-reversible phthalocyanine nanoemulsions for glioma-targeted dual-modal imaging and self-oxygenated phototherapy [0.03%]
用于胶质瘤靶向双模态成像和自我增氧光动力治疗的氟化可逆电荷菲咯啉纳米乳液
Tingjuan Wu,Qiao Yu,Jing Zhang et al.
Tingjuan Wu et al.
Gliomas are highly aggressive brain tumors with poor prognosis, limited by inadequate targeting, tumor hypoxia, and the restrictive blood-brain barrier (BBB). Here, we present a fluorinated phthalocyanine manganese-based nanoemulsion for du...
A DPEP1-Binding and mitochondria-targeted nanocomposite relieves acute respiratory distress syndrome by inhibiting Drp1-mediated mitochondria fission [0.03%]
一种DPEP1结合的、线粒体靶向的纳米复合材料通过抑制Drp1介导的线粒体分裂来缓解急性呼吸窘迫综合征
Ming He,Peng Zhang,Suya Bao et al.
Ming He et al.
Acute respiratory distress syndrome (ARDS), a severe condition associated with high mortality, is characterized by uncontrollable inflammation and oxidative stress linked to mitochondrial dysfunction. Dynamin-related protein 1 (Drp1) drives...
Nanotechnology for efficient delivery of TCM active ingredients in treating brain diseases [0.03%]
纳米技术在提高中药有效成分治疗脑病递送效率中的应用研究
Yuting Yang,Yufei Gao,Junping Li et al.
Yuting Yang et al.
Brain diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), brain tumors, and stroke, remain difficult to treat due to the restrictive nature of the blood-brain barrier (BBB). Traditional Chinese medicine (TCM) bioactive c...
A memristor-based method for discriminating tuberculous and malignant pleural effusions [0.03%]
一种基于忆阻器鉴别肺结核和恶性胸腔积液的方法
Miaomiao Liu,Jian Wang,Zelin Cao et al.
Miaomiao Liu et al.
Distinguishing malignant pleural effusion (MPE) from tuberculous pleural effusion (TPE) is important, as the underlying diseases (tuberculosis and advanced malignancies) are major public health concerns. However, an efficient method for dif...