CD24-targeted cystine and glucose oxidase cascade catalytic nanosystem triggers disulfidptosis in neuroblastoma [0.03%]
靶向CD24的半胱氨酸和葡萄糖氧化酶级联催化纳米系统触发神经母细胞瘤内二硫键依赖性蛋白水解
Tao Mi,Junhong Liu,Junyi Luo et al.
Tao Mi et al.
Neuroblastoma remains a challenging pediatric malignancy with limited therapeutic options, often complicated by chemoresistance and severe systemic toxicity. In this study, we developed a CD24-targeted nanodrug delivery platform that co-del...
Biocompatible injectable glycyrrhizic acid-based growth factor hydrogel for synergistic endometrial regeneration [0.03%]
一种用于协同子宫内膜再生的生物相容性甘草酸基生长因子注射水凝胶
Hongqiao Cai,Jing Wang,Yanan Zheng et al.
Hongqiao Cai et al.
Regenerative therapies for endometrial repair are crucial for treating intrauterine adhesions (IUA) and restoring fertility. In this study, we present a biocompatible injectable GHD hydrogel based on glycyrrhizic acid (GA) and dopamine-modi...
Surface modification of probiotics at single-cell resolution: Strategies, applications, and future directions in inflammatory bowel disease [0.03%]
益生菌单细胞改性在炎症性肠病中的策略、应用及未来方向研究
Li Peng,Xinyu Wang,Yafen Wang et al.
Li Peng et al.
Inflammatory bowel disease (IBD) manifests as a chronic immune-mediated gastrointestinal disorder is characterized by multifactorial pathogenesis involving dysregulated immune responses and intestinal dysbiosis. This pathobiological interpl...
Ligand-metal charge transfer and photothermal carbon dots synergistically enhance cerium dioxide nanozyme activity for diabetic infected wound healing [0.03%]
配体金属电荷转移和光热碳点协同增强二氧化铈纳米酶活性以促进糖尿病感染伤口愈合
Weian Wu,Yunxin Ye,Qiuhui Jiang et al.
Weian Wu et al.
Cerium oxide nanoparticles (CeO2 NPs), with intrinsic antioxidant, pro-oxidative activity under acidic conditions, and antibacterial properties, have been explored for diabetic wound therapy. However, their poor stability and limited cataly...
Thermo-responsive shape memory biomaterials with structural and physical adaptivity for scarless personalized nerve repair [0.03%]
具有结构和物理适应性的温敏性形状记忆生物材料用于无疤痕的个性化神经修复
Tao Gao,Jiahui Song,Lu Li et al.
Tao Gao et al.
Nerve guidance conduits (NGCs) have emerged as promising alternatives to autologous nerve grafts for peripheral nerve repair, overcoming donor site morbidity while promoting axonal regeneration. However, size and structure mismatch in conve...
Ultra-small coordination dihydromyricetin nanodots attenuate alveolar bone resorption in periodontitis through inhibition of ITGB3-Driven osteoclast differentiation [0.03%]
纳米点型二氢杨梅素通过抑制ITGB3驱动的破骨细胞分化来缓解牙周炎中的牙槽骨吸收
Bin Zhao,Shuqi Sun,Yicheng Hao et al.
Bin Zhao et al.
Irreversible alveolar bone resorption induced by periodontitis constitutes a major etiological factor in adult tooth loss, with its underlying pathological mechanism tightly linked to dysregulated osteoclast differentiation. Conventional cl...
Targeted inhibition of MDSC-derived exosomal miR-155-5p restrains epithelial-mesenchymal transition in hormone receptor-positive breast cancer by regulating SIRT1 [0.03%]
靶向抑制MDSC来源的外泌体miR-155-5p通过调控SIRT1限制激素受体阳性乳腺癌上皮间质转化
Guidong Chen,Silei Wang,Fanchen Wang et al.
Guidong Chen et al.
Breast cancer is one the most common cancers in women, with 70 % of cases being hormone receptor-positive (HR+), and recurrence and distant metastasis are the leading causes of mortality. Myeloid-derived suppressor cells (MDSCs) are one of ...
"AND" or "OR" logic operations of DNA probes: Fluorescent detection and discrimination of ovarian cancer cells via dual-microRNA in complex environments [0.03%]
基于DNA探针“与”或“或”逻辑运算的复杂背景下的卵巢癌细胞荧光检测及鉴别分析
Guanghui Wang,Yuting Li,Shuangjie Liu et al.
Guanghui Wang et al.
The development of DNA logic circuits has enabled novel signal carriers for the identification of cancer cells. Addressing the limitations of single-target detection in ovarian cancer, including insufficient specificity and signal delay, th...
Multilayered structure on titanium implants promotes diabetic osseointegration through synergetic regulation of oxidative balance and immune homeostasis in microenvironment [0.03%]
钛种植体的多层结构通过协同调节微环境中的氧化平衡和免疫稳态促进糖尿病骨整合
Yao Xiao,Gaoyang Wang,Maowen Chen et al.
Yao Xiao et al.
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia and chronic inflammation, which is considered a relative contraindication for implantation in clinical practice. In the pathological microenvironment of DM, the en...
Flow-driven construction of capillary-scale vessels with predefined geometries in natural hydrogels [0.03%]
基于天然水凝胶的微流控血管化构建方法研究
Akira Ono,Ryohei Ouchi,Yusei Kumagai et al.
Akira Ono et al.
Forming capillary networks with predefined geometries is a critical challenge in engineering complex three-dimensional tissues in vitro. While bioprinting and microfluidic technologies have enabled vascular tissue fabrication, precise contr...