Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes [0.03%]
基于聚合物的特应性皮炎药物递送系统最新研究进展：增强治疗效果和预后疗效
Yejin Kim,Kinam Park,Moon Suk Kim
Yejin Kim
Atopic dermatitis (AD) is a chronic, multifactorial skin condition characterized by impaired skin barrier function, immune dysregulation, and persistent inflammation. It significantly diminishes patients' quality of life due to frequent rel...
Engineered calcium carbonate-modiated SAzymes with Mn-based single-atom sites for ultrasound-enhanced nanocatalytic therapy [0.03%]
一种用于超声增敏单原子纳米催化的工程化含锰单原子位点的碳酸钙修饰SAzyme
Xiao Wang,Bingyu Xu,Fang Li et al.
Xiao Wang et al.
The construction of highly effective therapeutic nano-systems will be of great interest in the investigation of cancer treatment; however, developing such the platforms face significant challenges originated from the strict tumor microenvir...
Engineered Lactococcus lactis biovaccine containing NY-ESO-1 long peptides as potent immunotherapeutics [0.03%]
一种含有NY-ESO-1长肽的工程乳酸菌生物疫苗作为有效的免疫治疗药物
Chunyi Li,Kongcheng Wang,Jie Shao et al.
Chunyi Li et al.
Peptide vaccines have potential for tumour immunotherapy but face challenges in clinical trials, such as human leukocyte antigen limitations, potential cytotoxic T lymphocyte tolerance, short T-cell response duration, weak immune response, ...
Overcoming chemoresistance via NO-mediated HSP inhibition using hybrid membrane-coated multifunctional nanoplatforms [0.03%]
用于NO介导的HSP抑制以克服化学抗性基于杂化膜包覆多功能纳米平台
Maierhaba Aili,Fangrui Lin,Yu Chen et al.
Maierhaba Aili et al.
Chemotherapy resistance and the precise delivery as well as controlled release of drugs at tumor sites remain major challenges in cancer treatment. Heat shock proteins (HSPs) have been identified as key contributors to chemotherapy resistan...
ATG7-driven mitophagy in BMSC@CS hydrogel reprograms metabolism to boost bone regeneration [0.03%]
ATG7驱动的线粒体自噬促进骨髓间充质干细胞@壳聚糖水凝胶代谢重组从而促进骨再生
Qiumei Lan,Mengtian Fan,Fengmei Zhang et al.
Qiumei Lan et al.
Bone regeneration remains a formidable challenging due to impaired energy metabolism and the limited osteogenic potential of transplanted stem cells. Mitochondrial homeostasis orchestrates osteogenesis, with mitophagy maintaining the metabo...
Integrated biofabrication of artificial esophageal scaffolds using electrospinning, embedded DLP, and extrusion techniques [0.03%]
基于电纺丝、嵌入式DLP和挤出技术的食道支架集成生物制造
Priya Ranganathan,Seung Hoon Han,In Gul Kim et al.
Priya Ranganathan et al.
Esophageal reconstruction faces critical challenges due to limitations in current techniques, including inadequate mechanical properties, poor tissue integration, and insufficient functional regeneration. This study presents a novel biofabr...
Lactoferrin-cyanidin-3-glucoside nanoparticles alleviate inflammation and oxidative stress via Sesn2/Nrf2 activation in mastitis [0.03%]
乳铁蛋白- Cyanidin-3-葡萄糖苷纳米颗粒通过Sesn2/Nrf2激活缓解乳腺炎的炎症和氧化应激作用
Fructueux Modeste Amona,Yipeng Pang,Xiaohan Chen et al.
Fructueux Modeste Amona et al.
Mastitis, driven by oxidative-inflammatory responses to S. aureus, lacks efficient therapies. Recently, protein-anthocyanin encapsulation has shown significant advances in biomedicine, but it faces structural stability/suboptimal efficiency...
A dual-enzyme-like nanozyme adjuvant alleviates tumor hypoxia to enhance photothermally ferroptosis-immune synergistic tumor therapy [0.03%]
一种类酶纳米佐剂缓解肿瘤低氧以增强光热铁死亡-免疫协同抗肿瘤疗法
Peng Chang,Dehong Chen,Xiaoyu Yang et al.
Peng Chang et al.
Immune adjuvants play a critical role in cancer vaccines and emerging therapies. However, conventional adjuvants may fail to effectively stimulate cytotoxic T lymphocyte (CTL)-mediated immune responses. Nanozyme-based adjuvants, particularl...
Sodium butyrate enhances sorafenib-induced ferroptosis and immunogenic cell death by modulating IRF2-Oasl2-cGAS pathway in colorectal cancer [0.03%]
丁酸钠通过调节IRF2-Oasl2-cGAS通路增强 Sorafinib诱导的结直肠癌细胞铁死亡和免疫原性细胞死亡
Ying Xiang,Jinyu Zheng,Xinlu Zhao et al.
Ying Xiang et al.
While much attention has been focused on the direct cytotoxic effects of anticancer agents on tumor cells, emerging evidence suggests that the induction of immunogenic cell death (ICD) and the consequent remodeling of the tumor microenviron...
The injectable cationic double-crosslinked hydrogel facilitates bone regeneration and repair through sustained antibacterial activity [0.03%]
注射用阳离子双重交联水凝胶通过持续的抗菌活性促进骨再生和修复
Yimeng Xie,Yuedi Yu,Zhengwei Cai et al.
Yimeng Xie et al.
Due to the barrier effect of dental plaque and the growing issue of antibiotic resistance, the efficacy of conventional antimicrobial agents against oral pathogens has progressively declined. Chronic periodontal infections are recalcitrant ...