Hydrogel delivering self-assembled herbal nanoparticles accelerates diabetic wound healing through mitochondrial regulation [0.03%]
通过调节线粒体功能促进糖尿病伤口愈合的自组装中药纳米粒子水凝胶
Jiahe Guo,Ben Hu,Yi Wei et al.
Jiahe Guo et al.
The persistence of inflammation and mitochondrial dysfunction poses considerable challenges in the process of diabetic wound healing. Evidence from earlier research has revealed the significant activation of inflammation-related pathways in...
RGD-grafted dextran methacrylate hydrogel incorporating osteogenic peptide and Mn3O4 nanozymes for enhanced bone defect healing [0.03%]
一种整合了促骨形成肽和Mn3O4纳米酶的RGD接枝的DEX-MA水凝胶用于增强骨缺损修复
Yuxuan Pang,Xin Wang,Huan Zhang et al.
Yuxuan Pang et al.
Aggressive inflammation triggered by excessive reactive oxygen species (ROS) seriously disrupts intercellular communication between macrophages and tissue regenerative cells, such as bone marrow mesenchymal stem cells (BMSCs) and vascular e...
Carrier-free procyanidin-ferric nanonetworks loading gefitinib to inhibit TMEM16A-EGFR mutual activation loop for photothermally enhanced breast cancer targeted therapy [0.03%]
无载体原花青素-铁纳米网络负载吉非替尼抑制TMEM16A-EGFR互活环用于乳腺癌光热增效靶向治疗
Gen Li,Chunxiu Cai,Ning Zhang et al.
Gen Li et al.
The calcium-activated chloride channel TMEM16A is frequently overexpressed in breast cancer, establishing a reciprocal activation loop with EGFR signaling pathways that play a crucial role in the proliferation of breast cancer. Consequently...
Biofabrication of a 3D human skeletal muscle microenvironment to study the early steps of fibrosis [0.03%]
用于研究纤维化早期阶段的三维人体骨骼肌微环境生物制造
R Francescato,M Ishmaku,G Talò et al.
R Francescato et al.
Image 1. © 2025 The Authors.
Dual-function hemoglobin-encapsulating ZIF-8 nanoparticles: Oxygen transport capability and carbonic anhydrase-like activity [0.03%]
双重功能的血红蛋白包封ZIF-8纳米颗粒：氧气运输能力和碳酸酐酶活性
Ana María Pablo-Sainz-Ezquerra,Marta Rubio-Huertas,Ege Tini Tunca et al.
Ana María Pablo-Sainz-Ezquerra et al.
Hemoglobin-based oxygen carriers (HBOCs) have emerged as a promising alternative to red blood cell (RBC) transfusions, addressing key limitations such as cold storage requirements, restricted availability of universal donor blood, and the n...
Selenium-functionalized hyaluronic acid dissolvable microneedle patch synergistic herbal shikonin-loaded tetrahedral framework nucleic acids for psoriasis therapy [0.03%]
装饰有透明质酸的硒化微针贴剂协同四面体框架核酸递送土大黄素治疗银屑病
Mengting Zhuo,Ni Cheng,Jiaqi Du et al.
Mengting Zhuo et al.
Psoriasis is a complex, chronic inflammatory skin disease for which current therapies are limited by systemic toxicity, rapid relapse, and incomplete resolution. Despite advances in microneedle (MN)-assisted transdermal drug delivery, conve...
3D-printed GelMA-Alginate microsphere scaffold with staged dual-growth factor release for enhanced bone regeneration [0.03%]
一种用于促进骨再生的分阶段双重生长因子释放的3D打印明胶甲基丙烯酸酯-海藻酸盐微球支架
Enhui Zhou,Peipei He,Zefeng Yang et al.
Enhui Zhou et al.
The process of bone regeneration is inherently complex, relying on the precise regulation of multiple growth factors. However, when bone defects exceed a critical size, this delicate regulatory balance is disrupted, severely hindering new b...
Size-optimized ceria nanoparticles attenuate intervertebral disc degeneration by rescuing nucleus pulposus cell senescence via reducing oxidative stress and stimulating PI3K/AKT pathway [0.03%]
尺寸优化的氧化铈纳米颗粒通过减少氧化应激和刺激PI3K / AKT途径来挽救纤维环细胞衰老，从而缓解椎间盘退变
Xinxing Wang,Zhiwei Liu,Ling Zou et al.
Xinxing Wang et al.
Intervertebral disc degeneration (IVDD), a condition characterized by nucleus pulposus (NP) cell senescence and extracellular matrix (ECM) degradation, is a major cause of degenerative spinal disorders. Current clinical management remains l...
Acetylated chitosan scaffolds modulate the micro-environment and promote peripheral nerve regeneration through macrophage TLR2/4 pathway activation [0.03%]
乙酰化壳聚糖支架通过巨噬细胞TLR2/4途径活化调节微环境促进周围神经再生
Yuhui Jiang,Suqing Li,Mingyue Chang et al.
Yuhui Jiang et al.
Current nerve repair materials have limited capacity to actively regulate the regenerative micro-environment, lack effective intervention strategies and clarity mechanisms, resulting in insufficient tissue repair and regeneration capabiliti...
Targeted biomimetic fusogenic liposome enhances tumor accumulation, penetration, and therapeutic efficacy of siRNA therapeutics [0.03%]
靶向仿生融合型脂质体增强siRNA肿瘤递送及治疗效果
Xuejuan Zhao,Keyun Wu,Yuluo Zhang et al.
Xuejuan Zhao et al.
Blocking the CD47-SIRPα signaling pathway to promote macrophage phagocytosis represents a promising strategy for cancer therapy. RNA interference offers a safe and efficient means to disrupt this pathway, highlighting the importance of dev...