An Insight into Synthetic Strategies, SAR Study and Anticancer Mechanism of Chalcone Derivatives: Medicinal Chemistry Perspective [0.03%]
香豆素衍生物的合成策略、构效关系研究及抗癌机制的药物化学视角解析
Dipanjan Karati,Dileep Kumar
Dipanjan Karati
Chalcone derivatives continue to captivate medicinal chemists due to their modest chemistry, facile synthetic method, and promising biological activities. They have become wellknown in the therapeutic and pharmaceutical industries due to th...
Modulation of Angiotensin-II and Angiotensin 1-7 Levels Influences Cardiac Function in Myocardial Ischemia-reperfusion Injury [0.03%]
血管紧张素-II和血管紧张素1-7水平的调控影响心肌缺血再灌注损伤中的心脏功能
Prabhat Kumar Upadhyay,Navneet Thakur,Vishal Kumar Vishwakarma et al.
Prabhat Kumar Upadhyay et al.
The angiotensin-converting enzyme-2 (ACE-2) alters the pathophysiology of various fatal cardiovascular diseases, including ischemic heart disease, whereas angiotensin 1-7 (Ang 1-7) exerts a wide range of actions. The effects of ischemia-rep...
Unravelling the Complex Interplay: Understanding Drug-induced Diseases and Teratogenicity from a Comprehensive Perspective [0.03%]
解码复杂互作：从全面的角度理解药物引起的疾病和致畸性
Kartikay Prakash,Shashank Tiwari
Kartikay Prakash
Iatrogenic diseases, also referred to as drug-induced diseases (DIDs), represent a recognized yet inadequately investigated phenomenon that may result in enduring afflictions, hospital admissions, pharmacological interventions, protracted p...
Efflux-mediated Multidrug Resistance in Critical Gram-negative Bacteria and Natural Efflux Pump Inhibitors [0.03%]
关键革兰氏阴性菌的外排中介多药耐药及天然的外排泵抑制剂
Praveena Nanjan,Vanitha Bose
Praveena Nanjan
Multidrug Resistance mechanisms in microorganisms confer the slackness of the existing drugs, leading to added difficulty in treating infections. As a consequence, efficient novel drugs and innovative therapies to treat MDR infections are n...
The Journey of Methotrexate and Potential Alternative Pharmacotherapies for Rheumatoid Arthritis [0.03%]
甲氨蝶呤的治疗历程及类风湿关节炎的潜在替代药物疗法
Snehanjana Patra,Tania Pal Choudhury,Sanchari Barman
Snehanjana Patra
Background: Rheumatoid Arthritis (RA) is a systemic inflammatory auto-immune disorder chiefly described by synovitis followed by extra-articular manifestations of organ association such as pneumonia in addition to the cli...
Prasoon Pandey,Ritika Singh,Shefali Srivastava et al.
Prasoon Pandey et al.
Osteoarthritis (OA) is a disease characterized by degeneration of cartilage or wear and tear. OA is a cause of disability and health issues. It is a disease that affects more than 500 million adults annually worldwide, of which India accoun...
Novel Approaches for the Treatment of Pulmonary Fibrosis with Emphasis on the Role of Galectin-3 Inhibitors as a Potential Therapeutic Approach [0.03%]
肺纤维化治疗的新方法，重点介绍半乳糖凝集素-3抑制剂作为潜在治疗方法的作用
Tanya Mathur,Indu Singh
Tanya Mathur
Pulmonary fibrosis is a disease affecting the lungs and the respiratory system that carries along a high fatality rate with no specific therapeutic approaches, making it a disorder sometimes termed as incurable. There have been various rese...
Developments in Emerging Topical Drug Delivery Systems for Ocular Disorders [0.03%]
用于眼病的新颖局部给药系统的研究进展
Suraj Mandal,Prabhakar Vishvakarma,Km Bhumika
Suraj Mandal
According to the current information, using nano gels in the eye has therapeutic benefits. Industry growth in the pharmaceutical and healthcare sectors has been fueled by nanotechnology. Traditional ocular preparations have a short retentio...
Tacrolimus Pharmacotherapy: Infectious Complications and Toxicity in Organ Transplant Recipients; An Updated Review [0.03%]
他克莫司药物治疗：器官移植受者感染并发症和毒性；最新综述
Zahra Tolou Ghamari,Abbas Ali Palizban
Zahra Tolou Ghamari
Background: After allogeneic organ transplantation, in order to reduce the risk of rejection, tacrolimus is given. In fact, infection is reported as one of the most common side effects of tacrolimus that might be associat...
Advancement in Opioid Abuse-deterrent Formulation Technologies and Regulatory Expectation [0.03%]
阿片类药物滥用防护剂型研发进展及监管预期展望分析
Jayendrakumar Patel,Rakesh Patel
Jayendrakumar Patel
Chronic pain is a byproduct of many diseases and conditions. Along with long-term opioid medication use in chronic pain management, misuse of this vital medication has been a topic of much debate over the last two decades. Abuse-deterrent f...