Exploring Novel Therapeutic Avenues: Drug Repurposing for Neurodegenerative Movement Disorders [0.03%]
探索新的治疗途径：老药新用治疗神经退行性运动障碍
Pallavi Bassi,Shivani Rana,Vaibhav Sapra et al.
Pallavi Bassi et al.
Neurodegenerative movement disorders, encompassing conditions such as Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, represent a significant burden on individuals, families, and healthcare systems globally. Tr...
Antioxidant and Cytoprotective Effects of Different Compounds on Cyclophosphamide-induced Nephrotoxicity [0.03%]
不同化合物对环磷酰胺致肾毒性的抗氧化及细胞保护作用
Dayane Almeida Machado,Natasha Moreira de Castro Oliveira,Carla Speroni Ceron et al.
Dayane Almeida Machado et al.
Cyclophosphamide is a drug derived from nitrogenous mustards and is mainly indicated for the anti-neoplastic clinic. When it is metabolized in the liver, it produces acrolein, a cytotoxic metabolite capable of generating damage to the body....
A Narrative Overview of Retinoid X Receptor Inhibitors in Chronic Disease Management [0.03%]
维甲酸X受体拮抗剂在慢性疾病管理中的作用综述
Calvin R Wei,Muhammad Osama,Saleha Tahir
Calvin R Wei
The Retinoid X Receptor (RXR) is a member of the nuclear receptor superfamily and regulates gene transcription as well as diverse cellular processes like metabolism, inflammation, and cell differentiation. As an attractive therapeutic targe...
Vineet Kumar Rai
Vineet Kumar Rai
Neuroprotective Potential of Butrin: Mechanistic and Therapeutic Insights [0.03%]
白杨素的神经保护潜力：机制和治疗见解
Amulya Dhoddasomanahalli Prabhu,Prashant Tiwari,Sonal Dubey
Amulya Dhoddasomanahalli Prabhu
Introduction: Butrin, a flavonoid glycoside derived from Butea monosperma, has garnered attention for its neuroprotective effects attributed to its multifaceted pharmacological profile. It modulates dopamine and norepinep...
Revolutionizing Drug Delivery: The Promise of Self-emulsifying Systems in Overcoming Bioavailability Challenges [0.03%]
革命性药物输送：自乳化系统在克服生物利用度挑战方面的前景
Sonia Dhiman,Ashi Mannan,Maneesh Mohan et al.
Sonia Dhiman et al.
Introduction: The oral route is a preferred method for drug administration; however, lipophilic drugs often suffer from poor water solubility, significantly limiting their therapeutic effectiveness. Traditional approaches...
Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction [0.03%]
scopoletin药理活性：解开香豆素在认知障碍中的潜力
Pranay Wal,Shaili Vadera,Namra Aziz et al.
Pranay Wal et al.
Numerous therapeutic and culinary species produce scopoletin, a coumarin that is essential for treating a wide range of illnesses as a curative and chemopreventive agent. Globally, chronic illnesses are regarded as a major public health con...
Navigating Global Regulatory Divergence in Over-the-counter Drugs: Addressing Emerging Risks and Harmonization Challenges [0.03%]
全球非处方药监管差异的应对与协调挑战研究报告
Simran Nayan,Ankit Kolay,Shikha Baghel Chauhan et al.
Simran Nayan et al.
The worldwide market for over-the-counter (OTC) medications is quickly developing, providing consumers with increased self-medication options while facing substantial regulatory issues due to varied approval procedures, labeling regulations...
Thiopentone in Combination with Xylazine: An Experimental Investigation for Induction of Surgical Anesthesia and Safe Recovery in Experimental Rats [0.03%]
硫 pentone与 xylozen的联合应用：诱导实验大鼠外科麻醉和安全苏醒的实验研究
Sagar More,Radhika Mundke,Awez Sikkalgar et al.
Sagar More et al.
Introduction: Achieving reliable anesthesia induction and rapid postoperative recovery are crucial aspects of animal research, particularly in small experimental animals. Thiopentone is still a widely used anesthetic drug...
Next-generation Mesoporous Silica Nanoparticles: Precision-engineered Platforms for Ovarian Cancer Therapy [0.03%]
下一代介孔 silica 纳米粒子：精确工程卵巢癌治疗平台
Shankar Lal Tolani,Shashank Soni
Shankar Lal Tolani
Silica nanoparticles (SiNPs) with antifouling properties offer a promising approach for enhancing ovarian cancer (OC) therapy. OC remains one of the deadliest gynecological malignancies due to late-stage diagnosis, high recurrence rates, an...