The Interactions Between Alzheimer's Disease and Major Depression: Role of Ca2+ Channel Blockers and Ca2+/cAMP Signalling [0.03%]
阿尔茨海默病和抑郁症之间的相互作用：钙通道阻滞剂和钙/环磷酸腺苷信号传导的作用
Leandro Bueno Bergantin
Leandro Bueno Bergantin
Background: The interactions between Alzheimer's Disease (AD) and major depression can be translated into clinical data showing that depressive patients have had an enhanced risk for developing AD (later in life). The cel...
Molecular Dynamics Mechanisms of the Inhibitory Effects of Abemaciclib, Hymenialdisine, and Indirubin on CDK-6 [0.03%]
阿贝西利、隐花苷和靛红抑制CDK6的分子机制研究
Gholam Basati,Javad Saffari-Chaleshtori,Saber Abbaszadeh et al.
Gholam Basati et al.
Background: Cyclin-Dependent Kinases-6 (CDK-6) is a serine/threonine protein kinase with regular activity in the cell cycle. Some inhibitors, such as abemaciclib, hymenialdisine, and indirubin, cause cell arrest by decrea...
Protective Effect of Metformin, Resveratrol and Alpha-lipoic Acid on Radiation- Induced Pneumonitis and Fibrosis: A Histopathological Study [0.03%]
二甲双胍、白藜芦醇和α-硫辛酸对放射性肺炎和肺纤维化的保护作用：一项病理学研究
Rasoul Yahyapour,Peyman Amini,Hana Saffar et al.
Rasoul Yahyapour et al.
Background: Radiation-induced pneumonitis and fibrosis are the most common side effects of chest radiotherapy. They result from massive and chronic production of Reactive Oxygen Species (ROS), inhibition of antioxidant en...
Alcohol Consumption, Risky Sexual Behaviors, and HIV in Nigeria: A Meta-Analytic Review [0.03%]
尼日利亚的饮酒、高风险性行为和艾滋病：元分析回顾
Uzoamaka J Okoro,Kate B Carey,Blair T Johnson et al.
Uzoamaka J Okoro et al.
Background: Alcohol consumption is associated with risky sex, which increases the risk of acquiring and transmitting HIV. Objective: To...
Lithium Pharmacology and a Potential Role of Lithium on Methamphetamine Abuse and Dependence [0.03%]
锂药理学和锂对甲基苯丙胺滥用及依赖潜在作用的位点研究
Nobue Kitanaka,Frank Scott Hall,George Richard Uhl et al.
Nobue Kitanaka et al.
Background: The effectiveness of lithium salts in neuropsychiatric disorders such as bipolar disorder, Alzheimer's disease, and treatment-resistant depression has been documented in an extensive scientific literature. Lit...
The H-index in Life and Health Sciences: Advantages, Drawbacks and Challenging Opportunities [0.03%]
生命与健康科学中的H指数：优点、缺点及挑战机遇
Ricardo Jorge Dinis-Oliveira
Ricardo Jorge Dinis-Oliveira
In recent years, there has been a significant increase in the number of scientific publications. The h-index offers a consistent estimation method about a researcher's overall scientific achievements since it combines the total number of pu...
Enantiomeric Separation of Meclizine Hydrochloride in Pharmaceutical Dosage Form by HPLC Method [0.03%]
高效液相法测定盐酸美克洛嗪药品制剂中的对映体分离度研究方法学补充研究
Byran Gowramma,Ramachandran Senthil Kumar,Rajagopal Kalirajan et al.
Byran Gowramma et al.
Objective: A basic, powerful and isocratic chiral fluid chromatographic technique was created and approved for the enantiomeric partition of meclizine hydrochloride in pharmaceutical dose structure. ...
Lara Maria Lopes de Castro,Jacqueline de Souza,Tamires Guedes Caldeira et al.
Lara Maria Lopes de Castro et al.
Background: Solubility, intestinal permeability and dissolution are the main factors that govern the rate and extent of drugs absorption and are directly related to bioavailability. Biopharmaceutics Classification System ...
Imidazole: An Emerging Scaffold Showing its Therapeutic Voyage to Develop Valuable Molecular Entities [0.03%]
咪唑：一种展示其药物研发价值的新兴药效骨架分子实体
Bhawna Chopra,Ashwani K Dhingra,Deo Nandan Prasad
Bhawna Chopra
Objective: Imidazole is a heterocyclic moiety having immense biological importance. Since ancient times, the imidazole nucleus is considered to be a promising moiety in the field of chemistry. Preliminary in vitro and in ...
Khaleel Basha Sabjan,Syed Muzammil Munawar,Dhandayuthabani Rajendiran et al.
Khaleel Basha Sabjan et al.
Background: Objective: The stability and delivery of drugs remain one of the key hurdles in the present situation. The present study depends on the design of a novel nanoemulsion drugdelivery system that would encapsulate...