Ligand- and Structure-based Approaches for Transmembrane Transporter Modeling [0.03%]
基于配体和结构的转运蛋白建模方法
Melanie Grandits,Gerhard F Ecker
Melanie Grandits
The study of transporter proteins is key to understanding the mechanism behind multidrug resistance and drug-drug interactions causing severe side effects. While ATP-binding transporters are well-studied, solute carriers illustrate an under...
Tegoprazan as a New Remedy for Gastrointestinal Diseases in Comparison with its Therapeutic Predecessors: A Mini-Review [0.03%]
tegoprazan与胃肠道疾病治疗的先驱药物相比作为胃肠道疾病的新型疗法：综述
Asif Hossain Anik,Farhana Alam Proma,Pranoy Saha et al.
Asif Hossain Anik et al.
Background: Potassium-competitive acid blockers (P-CABs), such as tegoprazan, are a new and diverse class of drugs that can completely block the potassium-binding site of gastric H+/K+ ATPase, potentially overcoming the l...
Phytocannabinoids as Potential Multitargeting Neuroprotectants in Alzheimer's Disease [0.03%]
植物大麻素作为阿尔茨海默病多靶点神经保护剂的潜力
Sumit S Rathod,Yogeeta O Agrawal
Sumit S Rathod
The Endocannabinoid System (ECS) is a well-studied system that influences a variety of physiological activities. It is evident that the ECS plays a significant role in metabolic activities and also has some neuroprotective properties. In th...
Signaling pathways and molecular process of natural polyphenols in the amelioration of inflammatory bowel disease: A privileged scaffold in new drug discovery [0.03%]
天然多酚改善炎症性肠病的信号通路及分子机制：新药创制中的优势框架分子
Om Prakash,Ruchi Singh,Priyanka Bajpai et al.
Om Prakash et al.
Background: GIT is seriously affected by inflammatory bowel disease (IBD), which is characterized by extreme inflammation and an imbalance in a person's healthy life span. The frequency of occurrence of such chronic disea...
Is Daclatasvir a suitable substitute for Amphotericin B in the treatment of Mucormycosis when Amphotericin B is scarce? [0.03%]
当两性霉素B供应不足时，达克拉塞韦可否替代两性霉素B治疗曲霉病？
Pugazhenthan Thangaraju,Sree Sudha Tanguturi Yella,Vijayakumar Arumugam Ramamurthy et al.
Pugazhenthan Thangaraju et al.
Background: Mucormycosis has been infesting the universe for a while back, often with no prompt treatments. The disease devastation is spreading at an alarming rate. Many researchers are still hoping for a good potential ...
Biological Importance, Pharmacological Activities, and Nutraceutical Potential of Capsanthin: A Review of Capsicum Plant Capsaicinoids [0.03%]
辣椒素生物重要性、药理活性及其作为营养补充剂的潜力：植物Capsanthin综述
Kanika Patel,Dinesh Kumar Patel
Kanika Patel
Background: Carotenoids are natural hydrocarbons that play an important role in photomorphogenesis, photosynthesis, photoprotection, development, and defense mechanism of plants. Carotenoids have good anti-oxidants and pr...
Niraj Kumar Singh,Bharat Bhushan
Niraj Kumar Singh
Neurodegeneration is an elucidating feature of many neuronal disorders including Alz- heimer's, disease, Parkinson's disease, and cerebral ischemia. These neurodegenerative disorders are a major public health concern with high mortality and...
Odevixibat: A Review of a Bioactive Compound for the Treatment of Pruritus Approved by the FDA [0.03%]
odevixibat：一种治疗瘙痒并获得FDA批准的生物活性化合物综述
Mayur Porwal,Arvind Kumar,Vaibhav Rastogi et al.
Mayur Porwal et al.
Odevixibat is synthesized through chemical modification of Benzothiazepine's structure. It is a tiny chemical that inhibits the ileal bile acid transporter and is used to treat a variety of cholestatic illnesses, including progressive famil...
Ravikant Sharma,Lalitha Suravarjhula,Madhuparna Banerjee et al.
Ravikant Sharma et al.
Targeted cancer therapy acts on targeted molecules, is less toxic to normal cells, and acts more specifically on cancer cells. The two primary strategies for preventing malignancy growth are the blocking of T-cell repression signals or forw...