Can the entorhinal cortex help distinguish healthy aging brains from pathological aging brains? [0.03%]
内侧颞叶脑区的功能连接可以用于区分正常老化和病理老化吗？
Akihiko Takashima,Riki Koike,Yoshiyuki Soeda
Akihiko Takashima
Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease [0.03%]
早发性记忆缺损和家族性阿尔茨海默病双敲除小鼠脑网络广泛重构
Christopher Borcuk,Céline Héraud,Karine Herbeaux et al.
Christopher Borcuk et al.
A critical challenge in current research on Alzheimer's disease (AD) is to clarify the relationship between network dysfunction and the emergence of subtle memory deficits in itspreclinical stage. The AppNL-F/MAPT double knock-in (dKI) mode...
Kristin Audunsdottir,Daniel S Quintana
Kristin Audunsdottir
Older adults have been neglected in biobehavioral oxytocin research. Emerging research indicates that oxytocin signaling activity fluctuates over the lifespan, which suggests that results from studies investigating youth and young adults ca...
Brain and cognitive ageing: The present, and some predictions (…about the future) [0.03%]
脑与认知衰老：现状及未来预测
Simon R Cox,Ian J Deary
Simon R Cox
Experiencing decline in one's cognitive abilities is among the most feared aspects of growing old [53]. Age-related cognitive decline carries a huge personal, societal, and financial cost both in pathological ageing (such as dementias) and ...
The 18 kDa translocator protein is associated with microglia in the hippocampus of non-demented elderly subjects [0.03%]
小胶质细胞中的18kDa转运定位蛋白与非痴呆老年人海马体的关系研究
Benjamin B Tournier,Christophe Snoeijs,Stergios Tsartsalis et al.
Benjamin B Tournier et al.
Increase in the brain expression of the 18 kDa translocator protein (TSPO) is considered as a marker of neuroinflammation in the context of brain diseases, such as Alzheimer's disease (AD). However, in non-demented subjects with Alzheimer's...
Multisensory integration precision is associated with better cognitive performance over time in older adults: A large-scale exploratory study [0.03%]
基于大规模的探索性研究：感觉整合精确度与老年人较好的认知表现相关
Rebecca J Hirst,Annalisa Setti,Céline De Looze et al.
Rebecca J Hirst et al.
Age-related sensory decline impacts cognitive performance and exposes individuals to a greater risk of cognitive decline. Integration across the senses also changes with age, yet the link between multisensory perception and cognitive ageing...
Exploring Cortical Proteins Underlying the Relation of Neuroticism to Cognitive Resilience [0.03%]
探索皮层蛋白的作用机制：神经质通过何种方式影响认知储备
Francine Grodstein,Lei Yu,Philip L de Jager et al.
Francine Grodstein et al.
Some individuals maintain cognitive health despite neuropathology. Targets impacting "cognitive resilience" may provide interventions for preventing dementia without decreasing neuropathology. Neuroticism represents the tendency to experien...
Short superficial white matter and aging: a longitudinal multi-site study of 1293 subjects and 2711 sessions [0.03%]
短皮质脊髓束与衰老关系：基于1293名受试者和2711个时间点的多中心纵向研究
Kurt G Schilling,Derek Archer,Fang-Cheng Yeh et al.
Kurt G Schilling et al.
It is estimated that short association fibers running immediately beneath the cortex may make up as much as 60% of the total white matter volume. However, these have been understudied relative to the long-range association, projection, and ...
Cerebral Aβ deposition in an Aβ-precursor protein-transgenic rhesus monkey [0.03%]
APP转基因恒河猴脑中Aβ沉积物的形成
Anthony W S Chan,In Ki Cho,Chun-Xia Li et al.
Anthony W S Chan et al.
With the ultimate goal of developing a more representative animal model of Alzheimer's disease (AD), two female amyloid-β-(Aβ) precursor protein-transgenic (APPtg) rhesus monkeys were generated by lentiviral transduction of the APP gene i...
Fiber Ball White Matter Modeling Reveals Microstructural Alterations in Healthy Brain Aging [0.03%]
纤维球白质建模揭示健康大脑衰老中的微结构变化
Siddhartha Dhiman,Stephanie Fountain-Zaragoza,Jens H Jensen et al.
Siddhartha Dhiman et al.
Age-related white matter degeneration is characterized by myelin breakdown and neuronal fiber loss that preferentially occur in regions that myelinate later in development. Conventional diffusion MRI (dMRI) has demonstrated age-related incr...