MiR-122-5p modulates ferroptosis via SLC7A11: A potential therapeutic target in autoimmune hepatitis [0.03%]
miR-122-5p通过SLC7A11调节铁死亡：自身免疫性肝炎的潜在治疗靶点
Yuhong Suo,Yu Wang,Yu Su et al.
Yuhong Suo et al.
Background & aims: Autoimmune hepatitis (AIH) is a relatively rare cause of liver disease with a poor prognosis without intervention. Ferroptosis, a classical form of cell death, plays a crucial role in various diseases, ...
Exploration of shared biomarkers and mechanisms in systemic lupus erythematous and lung cancer via bioinformatics analysis [0.03%]
基于生物信息学分析探索系统性红斑狼疮和肺癌共有的生物标志物及机制
Chueh-Hsuan Hsu,Shuo-Chueh Chen,Yung-Luen Yu
Chueh-Hsuan Hsu
Systemic lupus erythematosus (SLE) patients exhibit a heightened risk of developing lung cancer, yet the underlying molecular mechanisms remain poorly understood. This study aimed to identify shared genetic factors linking SLE and LC using ...
A laboratory test to detect gliadin-specific CD4+ T-cells for difficult to diagnose celiac disease [0.03%]
用于诊断难以发现的乳糜泻的gliadin特异性CD4+T细胞实验室检测法
Daan A R Castelijn,Nicolette J Wierdsma,Kim de Buck et al.
Daan A R Castelijn et al.
Objectives: Discrepancy between serology and small bowel histology, such as seronegative CD, poses a diagnostic challenge in celiac disease (CD) diagnosis. Recently described methods to detect gliadin-specific T-cells are...
Hyperimmunoglobulin syndromes: A review of HIGM, HIES, and HIDS [0.03%]
高免疫球蛋白综合征：HIGM、HIES 和 HIDS 综述
Wushu Chen,Xingpei Li,Junye Mai et al.
Wushu Chen et al.
At present, there is a lack of detailed understanding and research on the pathogenesis and treatment of Hyperimmunoglobulin M syndrome (HIGM), Hyperimmunoglobulin E syndrome (HIES), and hyperimmunoglobulin D syndrome (HIDS), and few studies...
Matrix remodeling-associated protein 5 as a novel biomarker for predicting disease activity and endoscopic response to infliximab in Crohn's disease [0.03%]
基质重塑相关蛋白5作为预测克罗恩病疾病活动及英夫利昔应答的新型生物标志物
Daopo Lin,Jiayue Xu,Mengqian Ye et al.
Daopo Lin et al.
The primary objective of treating Crohn's disease (CD) is to achieve and sustain endoscopic remission. However, repeated endoscopic examination leads to decreased patient compliance and procedural risks. Non-invasive biomarkers for endoscop...
Autoimmune manifestations in children with inborn errors of immunity in Morocco: A study from the national registry [0.03%]
摩洛哥遗传性免疫缺陷儿童的自身免疫表现：国家登记处的研究
Ahamada Elamine,Ibtihal Benhsaien,Fatima Ailal et al.
Ahamada Elamine et al.
Inborn Errors of Immunity (IEI) are a heterogeneous group of genetic disorders characterized by increased susceptibility to infections and immune dysregulation, including autoimmunity and autoinflammation. Despite their clinical significanc...
An international multicenter retrospective analysis of repeated anti-ENA testing in ANA-associated rheumatic diseases, a data-driven proposal to increase testing efficacy [0.03%]
基于数据驱动的提高ANA相关自身免疫性疾病中反复检测抗ENA抗体有效性的国际多中心回顾性分析
Wim H M Vroemen,Maria Infantino,Mariangela Manfredi et al.
Wim H M Vroemen et al.
Background: Autoantibodies detection in ANA-associated rheumatic diseases (AARD) is not only used for diagnostic and classification purposes, but also for monitoring. In case of AARD it is questioned if repeated anti-ENA ...
Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus [0.03%]
天然和适应性淋巴细胞免疫的失调可能对神经精神系统性红斑狼疮的症状归属以及对靶向治疗的反应具有重要意义
Julius Lindblom,Guillermo Barturen,Lorenzo Beretta et al.
Julius Lindblom et al.
Objectives: To gain insights into the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) and identify potential drug targets through investigation of whole-blood human transcriptome. ...
Pedro Carrera-Bastos,Abel Plaza-Florido,Alejandro Santos-Lozano et al.
Pedro Carrera-Bastos et al.
Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We co...
Epigenetic regulation of thrombo-inflammation in Behçet and antiphospholipid syndrome [0.03%]
白塞病和抗磷脂综合征中表观遗传调控的血栓炎症反应
Alessandra Bettiol,Giacomo Bagni,Francesca Di Patti et al.
Alessandra Bettiol et al.
Background: An epigenetic regulation of thrombo-inflammation has been reported in Behçet syndrome (BS), likely driven by a unique profile of three plasmatic circulating microRNAs (ci-miRNAs) (miR-206, miR-224-5p, and miR...