The antibody repertoire of autoimmune sensory neuronopathies targets pathways of the innate and adaptive immune system. An autoantigenomic approach [0.03%]
自身免疫性感觉神经病的抗体谱针对先天性和适应性免疫系统的途径。一种自动抗原基因组学方法
Christian P Moritz,Yannick Tholance,Nadia Boutahar et al.
Christian P Moritz et al.
Sensory neuronopathies (SNN) encompass diverse etiologies, with autoimmunity playing a major role through both cellular and humoral responses. To investigate the humoral autoantibody repertoire in autoimmune SNN, we conducted a retrospectiv...
Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus [0.03%]
IFN-α增强CD8+T细胞的细胞毒性暗示其在系统性红斑狼疮中的另一种病理作用
Chen-Xing Zhang,You-Ying Mao,Yu-Pin Tan et al.
Chen-Xing Zhang et al.
Objective: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease which is affected by the environmental, genetic factors as well as the immune system. Previous reports have implicated IFN-α in the path...
Marco Di Tola,Hetty J Bontkes,Juan Irure-Ventura et al.
Marco Di Tola et al.
Celiac disease (CD) is a very common immune-mediated enteropathy resulting from the interaction between dietary gluten and the immune system in genetically predisposed individuals. The immune response leads to intestinal damage, malabsorpti...
Liqi Zhu,Yuanyuan Liang,Linghan Yang et al.
Liqi Zhu et al.
Background: Autoimmune hepatitis (AIH) is a chronic progressive liver disease caused by the immune system mistakenly attacking its own hepatocytes. The role of the gut microbiome in the pathogenesis and progression of AIH...
Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients [0.03%]
放射学轴向脊柱关节炎患者循环双阴性2B细胞的异常B细胞受体信号反应
Rick Wilbrink,Stefan F H Neys,Rudi W Hendriks et al.
Rick Wilbrink et al.
Objective: Radiographic axial spondyloarthritis (r-axSpA) is a chronic rheumatic disease in which innate immune cells and T cells are thought to play a major role. However, recent studies also hint at B cell involvement. ...
Pedro Franco-Fuquen,Juana Figueroa-Aguirre,David A Martínez et al.
Pedro Franco-Fuquen et al.
A substantial proportion of patients diagnosed with rheumatologic and musculoskeletal diseases (RMDs) exhibit resistance to conventional therapies or experience recurrent symptoms. These diseases, which include autoimmune disorders such as ...
Tofacitinib downregulates JAK1 and JAK3 on human intestinal monocytes and macrophages without affecting dendritic cells phenotype or function [0.03%]
托法替尼下调人类肠道单核细胞和巨噬细胞上的JAK1和JAK3而不影响树突状细胞的表型或功能
Elisa Arribas-Rodríguez,Ángel De Prado,Beatriz de Andrés et al.
Elisa Arribas-Rodríguez et al.
Background: Ulcerative colitis (UC) is an inflammatory disorder of the gastrointestinal tract. Although Tofacitinib, which inhibits the JAK1 and JAK3 signalling pathway, is approved to treat patients with UC, its specific...
The added value of coupling anti-dsDNA and anti-chromatin antibodies in follow-up monitoring of systemic lupus erythematosus patients [0.03%]
抗ds-DNA抗体和抗染色质抗体在系统性红斑狼疮患者随访监测中的联用价值分析
Caroline Carlé,Françoise Fortenfant,Chloé Bost et al.
Caroline Carlé et al.
Objective: The autoimmune response to chromatin (Chr) or one of the nucleosome components (double stranded (ds)DNA and histones) is typically associated with the development of systemic lupus erythematosus (SLE). Related ...
Autoantibodies in systemic sclerosis: From disease bystanders to pathogenic players [0.03%]
系统性硬化症中的自身抗体：从疾病旁观者到致病因子
Aurélien Chepy,Aurore Collet,David Launay et al.
Aurélien Chepy et al.
Autoantibodies (Aab) are recognized as key indicators in the diagnosis, classification, and monitoring of systemic autoimmune diseases (AID). Recent studies have expanded knowledge through the discovery of new antigenic targets, advanced me...
Monitoring the follow-up of autoimmune chronic atrophic gastritis using parietal cell antibodies and markers of gastric function [0.03%]
自身免疫性慢性萎缩性胃炎的随访监测：壁细胞抗体和胃功能标志物的作用
Maria Piera Panozzo,Antonio Antico,Nicola Bizzaro
Maria Piera Panozzo
Increased interest in the pathogenesis and the evolution of autoimmune chronic atrophic gastritis (A-CAG) has led to the search for serological markers that can be used to detect changes in the gastric mucosa at an early stage and to monito...