Serum test for secretory component-containing anti-citrullinated protein antibodies as a novel prognostic tool in rheumatoid arthritis at-risk subjects [0.03%]
抗瓜氨酸蛋白抗体血清检测作为预测易感对象患类风湿性关节炎的新预后工具
Klara Martinsson,Simon Åhammar,Alexandra Cîrciumaru et al.
Klara Martinsson et al.
Individuals with autoantibodies against citrullinated proteins (ACPA) and musculoskeletal symptoms face increased risk of developing rheumatoid arthritis (RA). There are knowledge gaps concerning who will develop disease, and predictors of ...
Short-chain fatty acids from gut microbiota restore Th17/Treg balance in rheumatoid arthritis: Mechanisms and therapeutic potential [0.03%]
肠道菌群短链脂肪酸修复类风湿关节炎Th17/Treg失衡的机制及治疗潜力
Aimei Pang,Shuangshuang Pu,Yinghui Pan et al.
Aimei Pang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction. Dysregulation of the Th17/Treg balance is a key immunological hallmark of RA. Emerging evidence highlights the critical...
Splicing-based biomarkers define a robust multigene classifier for relapsing-remitting multiple sclerosis [0.03%]
基于拼接的生物标志物定义了复发缓解型多发性硬化的稳健多基因分类器
Federica Airi,Valeria Rimoldi,Elvezia Maria Paraboschi et al.
Federica Airi et al.
Background: Alternative splicing (AS) is recognized as a key mechanism in multiple sclerosis (MS). We aimed to construct and validate a multivariate AS-based classifier (MS-Splicing Score, MS-SS) for the discrimination of...
Redefining multiple sclerosis therapy through microbial immunomodulation and epigenetic control [0.03%]
通过微生物免疫调节和表观遗传控制重新定义多发性硬化症治疗方案
Shan Xu,Christina James Thomas,Sunilgowda Sunnagatta Nagaraja et al.
Shan Xu et al.
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by immune-driven demyelination and neurodegeneration in the central nervous system. This Review explores the immunological, molecular, and epigenetic underpinnings of MS, empha...
Regulatory T cell therapy for Sjögren's disease: From pathogenesis to targeted treatment [0.03%]
自身免疫性疾病的Tregs细胞治疗：从发病机制到靶向治疗研究
Zhi Feng Sherman Lim,Alberta Y Hoi,Fabien B Vincent et al.
Zhi Feng Sherman Lim et al.
Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by lymphocytic infiltration of the salivary and lacrimal glands, leading to the hallmark symptoms of dry eyes and dry mouth. Beyond glandular dysfunction, many...
Beyond conventional treatment: Novel cell therapies for systemic lupus erythematosus [0.03%]
超越传统治疗：系统性红斑狼疮的新型细胞疗法
Zeinab Zarei-Behjani,Arghavan Hosseinpouri,Maryam Fotoohi et al.
Zeinab Zarei-Behjani et al.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by its heterogeneity, as it can affect various organs and exhibit a diverse clinical progression. The identification of SLE relies on the presence of distinct clinica...
When the victim becomes the villain: Platelets as drivers of immune dysregulation in ITP [0.03%]
当“受害者”变成“加害者”：ITP中血小板作为免疫调节紊乱驱动者的角色
Fatemeh Farhid,Hadi Rezaeeyan,Reza Habibi et al.
Fatemeh Farhid et al.
Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated destruction of platelets and impaired platelet production. Although autoantibodies have historically been central to the understanding of ...
Targeted regulatory T cell activation by site-specific PEGylated interleukin-2 mitigates autoimmune inflammation [0.03%]
靶向定位的聚乙二醇修饰的白细胞介素-2激活调节性T细胞可减轻自身免疫炎症
Masahiro Ikeda,Shinpei Yamaguchi,Shigeki Takaoka et al.
Masahiro Ikeda et al.
Dysregulation of immune homeostasis accompanied by regulatory T cell (Treg) dysfunction is a hallmark of various autoimmune and inflammatory diseases. While low-dose interleukin-2 (IL-2) treatment can enhance Treg levels and alleviate disea...
Acylcarnitine enrichment as a characteristic of rheumatoid arthritis fibroblast-like synoviocyte metabolic fingerprint [0.03%]
肉碱酰基化物丰度是类风湿关节滑膜成纤维样细胞代谢特征的标志
Georgios K Vasileiadis,Yuan Zhang,Marion Laudette et al.
Georgios K Vasileiadis et al.
Objective: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) alter their metabolism to support their activation. We aimed to analyse the full spectrum of metabolic alterations associated with RA by performi...
Ye Zeng,Erika Boschmann,Julia Kotte et al.
Ye Zeng et al.
ANCA-vasculitis (AAV) is a small-vessel vasculitis characterized by the presence of autoantibodies against proteinase-3 (PR3) or myeloperoxidase (MPO). The dynamics of the T-cell response within tissues is studied best in animal models. It ...