The changes in global burden of autoimmune diseases two years after the COVID-19 pandemic: a trend analysis based on the Global Burden of Disease Study 2021 [0.03%]
基于全球疾病负担研究2021的新冠肺炎疫情后两年自身免疫性疾病疾病负担变化趋势分析
Danting Zhang,Wanyu Hua,Fangfang Sun et al.
Danting Zhang et al.
Background: Data on the epidemiological changes in the global burden of autoimmune diseases (ADs) after the Coronavirus disease 2019 (COVID-19) pandemic is lacking. This study investigated the impact of the COVID-19 pande...
A placebo-controlled Phase 2 trial of E6011, anti-human fractalkine monoclonal antibody, in primary biliary cholangitis [0.03%]
E6011（抗人 fractalkine 单克隆抗体）治疗原发性胆汁性肝硬化II期安慰剂对照临床试验
Atsushi Tanaka,Masanori Abe,Tadashi Namisaki et al.
Atsushi Tanaka et al.
Background: While ursodeoxycholic acid (UDCA) remains the first-line therapy for primary biliary cholangitis (PBC), the autoimmune nature of PBC underscores the need for treatments targeting immunological pathways that ma...
Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis [0.03%]
亮氨酸通过增强cGAS-STING-NLRP3通路促进自身免疫性甲状腺炎
Xin Shen,Tingting Feng,Shangbin Li et al.
Xin Shen et al.
Background: Branched-chain amino acids (BCAAs), including isoleucine (Ile), leucine (Leu), and valine (Val), are substrates for synthesising nitrogenous compounds and signalling molecules involved in regulating immunity. ...
Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell RNA-seq [0.03%]
通过空间转录组学和批量/单细胞RNA测序的综合分析揭示CD8+T细胞和内皮细胞在类风湿性关节炎中相互作用的关键作用
Yu Lai,Zishao Zhong,Runze Li et al.
Yu Lai et al.
Background: Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease. While the chemokine signaling pathway plays a pivotal role in RA pathogenesis, the specific cellular interactions remain unclear. ...
Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes [0.03%]
横跨组织转录组关联研究揭示了新型银屑病易感基因
Fei Yan,Jing Tao,Jie Liu et al.
Fei Yan et al.
Background: Psoriasis is a chronic, immune-mediated inflammatory skin disorder with a strong genetic component. Although numerous GWAS have identified risk loci, many associated variants lie in non-coding regions, complic...
Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases [0.03%]
空气中的罪魁祸首：PM、二氧化硅和TCDD在自身免疫疾病中的综述性研究
Daniel Galeano-Sánchez,Victoria Morales-González,Diana M Monsalve et al.
Daniel Galeano-Sánchez et al.
Autoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked t...
Pediatric autoimmune diseases in the light of COVID-19 pandemic, A retrospective observational big data study [0.03%]
COVID-19大流行背景下儿童自身免疫性疾病的大数据回顾性观察研究
Rim Kasem Ali Sliman,Hilla Cohen,Shereen Shehadeh et al.
Rim Kasem Ali Sliman et al.
Background: The COVID-19 pandemic has raised concerns about potential links between SARS-CoV-2 infection and autoimmune diseases. This study investigated changes in the incidence rate (IR) of autoimmune diseases among chi...
Arno Belpaire,Annelies Demeyer,Elise Van Caelenberg et al.
Arno Belpaire et al.
Despite significant progress in the treatment of alopecia areata (AA), many aspects of its immune-based pathogenesis remain unexplored. IFN-γ, primarily produced by CD8+ T cells and NK cells, is considered central to AA pathogenesis. Howev...
NETosis: A key player in autoimmunity, COVID-19, and long COVID [0.03%]
NETosis：自身免疫、COVID-19及长新冠中的关键参与者
Diana M Monsalve,Yeny Acosta-Ampudia,Nicolás Guerrero Acosta et al.
Diana M Monsalve et al.
NETosis, the process through which neutrophils release neutrophil extracellular traps (NETs), has emerged as a crucial mechanism in host defense and the pathogenesis of autoimmune responses. During the SARS-CoV-2 pandemic, this process rece...
Understanding the role of immune-mediated inflammatory disease related cytokines interleukin 17 and 23 in pregnancy: A systematic review [0.03%]
理解免疫介导的炎症疾病相关细胞因子白细胞介素17和23在妊娠中的作用：系统回顾
Aniek Plug,Liana Barenbrug,Bart G J Moerings et al.
Aniek Plug et al.
Background: Pregnancy requires a careful immune balance between tolerance for the semi-allogenic fetus and protection against pathogens. Women with immune-mediated inflammatory diseases (IMIDs), where the interleukin (IL)...