Matrix remodeling-associated protein 5 as a novel biomarker for predicting disease activity and endoscopic response to infliximab in Crohn's disease [0.03%]
基质重塑相关蛋白5作为预测克罗恩病疾病活动及英夫利昔应答的新型生物标志物
Daopo Lin,Jiayue Xu,Mengqian Ye et al.
Daopo Lin et al.
The primary objective of treating Crohn's disease (CD) is to achieve and sustain endoscopic remission. However, repeated endoscopic examination leads to decreased patient compliance and procedural risks. Non-invasive biomarkers for endoscop...
Autoimmune manifestations in children with inborn errors of immunity in Morocco: A study from the national registry [0.03%]
摩洛哥遗传性免疫缺陷儿童的自身免疫表现：国家登记处的研究
Ahamada Elamine,Ibtihal Benhsaien,Fatima Ailal et al.
Ahamada Elamine et al.
Inborn Errors of Immunity (IEI) are a heterogeneous group of genetic disorders characterized by increased susceptibility to infections and immune dysregulation, including autoimmunity and autoinflammation. Despite their clinical significanc...
An international multicenter retrospective analysis of repeated anti-ENA testing in ANA-associated rheumatic diseases, a data-driven proposal to increase testing efficacy [0.03%]
基于数据驱动的提高ANA相关自身免疫性疾病中反复检测抗ENA抗体有效性的国际多中心回顾性分析
Wim H M Vroemen,Maria Infantino,Mariangela Manfredi et al.
Wim H M Vroemen et al.
Background: Autoantibodies detection in ANA-associated rheumatic diseases (AARD) is not only used for diagnostic and classification purposes, but also for monitoring. In case of AARD it is questioned if repeated anti-ENA ...
Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus [0.03%]
天然和适应性淋巴细胞免疫的失调可能对神经精神系统性红斑狼疮的症状归属以及对靶向治疗的反应具有重要意义
Julius Lindblom,Guillermo Barturen,Lorenzo Beretta et al.
Julius Lindblom et al.
Objectives: To gain insights into the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) and identify potential drug targets through investigation of whole-blood human transcriptome. ...
Pedro Carrera-Bastos,Abel Plaza-Florido,Alejandro Santos-Lozano et al.
Pedro Carrera-Bastos et al.
Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We co...
Epigenetic regulation of thrombo-inflammation in Behçet and antiphospholipid syndrome [0.03%]
白塞病和抗磷脂综合征中表观遗传调控的血栓炎症反应
Alessandra Bettiol,Giacomo Bagni,Francesca Di Patti et al.
Alessandra Bettiol et al.
Background: An epigenetic regulation of thrombo-inflammation has been reported in Behçet syndrome (BS), likely driven by a unique profile of three plasmatic circulating microRNAs (ci-miRNAs) (miR-206, miR-224-5p, and miR...
A comparative study of different assays for autoantibodies detection in patients with autoimmune gastritis [0.03%]
自身免疫性胃炎患者自身抗体检测方法的比较研究
Małgorzata Osmola,Caroline Hémont,Marcin Romańczyk et al.
Małgorzata Osmola et al.
Objective: Autoimmune gastritis (AIG) is an important health problem and a risk factor for gastric neoplasms. This study assessed the diagnostic performance of different assays for anti-parietal cell antibodies (APCA) and...
Characteristics of polyclonal anti-interferon-gamma autoantibodies and novel diagnostic strategies: A prospective cohort study of new biomarkers [0.03%]
多克隆抗干扰素-γ自身抗体的特征及新的诊断策略：新生物标志物前瞻性队列研究
Xidong Wang,Feng Ye,Hongling Liu et al.
Xidong Wang et al.
Background: Anti-γ interferon autoantibody (AIGA) syndrome is a widespread and grossly underestimated immunodeficiency disorder characterized by high mortality rates and a lack of standardized diagnostic methods. A highl...
Carl Turesson,Johan Rönnelid,Alf Kastbom
Carl Turesson
Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressively destructive polyarthritis. Key autoimmune features include the presence of autoantibodies. The purpose of...
Quentin Simon,François Gaillard,John Tchen et al.
Quentin Simon et al.
Systemic lupus erythematosus (SLE) activity decreases in some patients with end-stage kidney disease (ESKD). The impact of ESKD on the immune cell profile of SLE patients and lupus activity remains unclear. In this study, we aimed at charac...