The clinical characteristics and treatment response of myasthenia gravis with positive thyroid peroxidase antibody or thyroid globulin antibody [0.03%]
甲状腺过氧化物酶抗体或甲状腺球蛋白抗体阳性的重症肌无力的临床特征及治疗反应
Hanyu Xin,Mingou Lu
Hanyu Xin
Background and purpose: Myasthenia gravis (MG) frequently associates with thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb), indicating shared autoimmunity. This study investigated the impact of TPOAb/...
Identification of key oxidative phosphorylation-related genes in systemic lupus erythematosus based on transcriptomics and bioinformatics analysis [0.03%]
基于转录组学和生物信息学分析识别系统性红斑狼疮中关键的氧化磷酸化相关基因
Shasha Wang,Hongmin Hu,Jingru Chen et al.
Shasha Wang et al.
Objective: Oxidative phosphorylation (OXPHOS) dysfunction is increasingly recognized as a key factor in systemic lupus erythematosus (SLE) pathogenesis. This study aimed to identify OXPHOS-related core genes as potential ...
Novel variants in ARID1B, SPSB1, and RAET1-AS shape genetic susceptibility and protection in systemic lupus erythematosus and lupus nephritis [0.03%]
ARID1B、SPSB1和RAET1-AS的新变异体塑造系统性红斑狼疮和狼疮性肾炎的遗传易感性和保护因素
Hung-Yi Chen,Feng-Cheng Liu,Hsian-Cheng Chen et al.
Hung-Yi Chen et al.
Background: Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by immune dysregulation affecting multiple organs, most notably lupus nephritis (LN). Genetic susceptibility significantly contributes...
The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy [0.03%]
m6A-circFOXK2在类风湿关节炎患者CD4+T细胞中的意义及circFOXK2与Th17%和自噬的相关性研究
Qing Luo,Zhiwei Wu,Qiuyun Xiao et al.
Qing Luo et al.
Objective: CD4+T cells are significant compositions of immune cells in rheumatoid arthritis (RA) and the aberrant function of CD4+T cells have been demonstrated to promote RA's progression. N6-methyladenosine (m6A) is a h...
Cre-driven tdTomato expression unexpectedly confers resistance to peripheral but not central lupus in dLckCre mice [0.03%]
意想不到的是，Cre驱动的tdTomato表达使dLck-Cre小鼠对周围狼疮具有抗性，但对中枢狼疮没有抗性
Ning Han,Keer Wang,Dan Yang et al.
Ning Han et al.
The Cre-driven tdTomato reporter system is widely used to visualize gene expression and cellular dynamics. Here we tested the impact of the tdTomato reporter system on the progression of both central and peripheral manifestations of systemi...
TGF-β1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3 [0.03%]
TGF-β1通过上调P4HA3促进系统性硬化症胶原合成
Zhaopeng Chen,Yinru Lin,Yayi Huang et al.
Zhaopeng Chen et al.
Objective: Systemic sclerosis (SSc) is a complex autoimmune disease resulting in fibrosis of skin and internal organs. Despite progress in treatment, SSc carries high mortality due to organ fibrosis. This study aimed to i...
Vitamin D3 encapsulated in polymeric nanoparticles to dampen the pro-inflammatory immune response [0.03%]
聚丙烯酸纳米粒子包裹维生素D3以抑制促炎免疫反应
Julia Minnee,Jorge Cuenca-Escalona,Johanna Bödder et al.
Julia Minnee et al.
1α25-dihydroxyvitamin D3, the active metabolite of vitamin D3 (VD3), is a modulator of inflammation well-known for its ability to promote anti-inflammatory and tolerogenic immune responses. It is therefore an attractive agent for the atten...
Clinical efficacy and immunomodulation of double-filtration plasmapheresis in autoimmune encephalitis: A prospective study highlighting the importance of timely initiation [0.03%]
双重过滤血浆置换治疗自身免疫性脑炎的临床疗效及免疫调节作用：一项前瞻性研究，强调及时启动的重要性
Hongyan Li,Kan Wang,Qiuju Li et al.
Hongyan Li et al.
Background and purpose: Double-filtration plasmapheresis (DFPP) has emerged as a plasma-saving alternative to therapeutic plasma exchange for autoimmune encephalitis (AE), but prospective evidence regarding its dual effec...
Immune responses to infection and autoimmune diseases in the UK biobank [0.03%]
英国生物样本库中感染和自身免疫疾病的免疫反应
Choa Yun,Dongwon Yoon,Sun Young Jung et al.
Choa Yun et al.
Background: Infections may trigger autoimmunity, but large-scale studies on antibodies to infections and their associations with autoimmune diseases are limited. We aim to better understand the etiologic role of infection...
Integrative mass spectrometry-driven multi-omics and single cell technologies in ankylosing spondylitis: insights into pathogenesis, biomarker discovery, and precision medicine [0.03%]
整合质谱驱动的多组学和单细胞技术在强直性脊柱炎中的应用：对发病机制、生物标志物发现及精准医疗的新见解
Yan Gao,Xinge Li,Fengting Luo et al.
Yan Gao et al.
Ankylosing spondylitis (AS), a chronic inflammatory arthritis primarily affecting the axial skeleton, presents significant clinical challenges due to its complex pathogenesis, delayed diagnosis, and heterogeneous therapeutic responses. This...