Cre-driven tdTomato expression unexpectedly confers resistance to peripheral but not central lupus in dLckCre mice [0.03%]
意想不到的是，Cre驱动的tdTomato表达使dLck-Cre小鼠对周围狼疮具有抗性，但对中枢狼疮没有抗性
Ning Han,Keer Wang,Dan Yang et al.
Ning Han et al.
The Cre-driven tdTomato reporter system is widely used to visualize gene expression and cellular dynamics. Here we tested the impact of the tdTomato reporter system on the progression of both central and peripheral manifestations of systemi...
TGF-β1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3 [0.03%]
TGF-β1通过上调P4HA3促进系统性硬化症胶原合成
Zhaopeng Chen,Yinru Lin,Yayi Huang et al.
Zhaopeng Chen et al.
Objective: Systemic sclerosis (SSc) is a complex autoimmune disease resulting in fibrosis of skin and internal organs. Despite progress in treatment, SSc carries high mortality due to organ fibrosis. This study aimed to i...
Vitamin D3 encapsulated in polymeric nanoparticles to dampen the pro-inflammatory immune response [0.03%]
聚丙烯酸纳米粒子包裹维生素D3以抑制促炎免疫反应
Julia Minnee,Jorge Cuenca-Escalona,Johanna Bödder et al.
Julia Minnee et al.
1α25-dihydroxyvitamin D3, the active metabolite of vitamin D3 (VD3), is a modulator of inflammation well-known for its ability to promote anti-inflammatory and tolerogenic immune responses. It is therefore an attractive agent for the atten...
Clinical efficacy and immunomodulation of double-filtration plasmapheresis in autoimmune encephalitis: A prospective study highlighting the importance of timely initiation [0.03%]
双重过滤血浆置换治疗自身免疫性脑炎的临床疗效及免疫调节作用：一项前瞻性研究，强调及时启动的重要性
Hongyan Li,Kan Wang,Qiuju Li et al.
Hongyan Li et al.
Background and purpose: Double-filtration plasmapheresis (DFPP) has emerged as a plasma-saving alternative to therapeutic plasma exchange for autoimmune encephalitis (AE), but prospective evidence regarding its dual effec...
Immune responses to infection and autoimmune diseases in the UK biobank [0.03%]
英国生物样本库中感染和自身免疫疾病的免疫反应
Choa Yun,Dongwon Yoon,Sun Young Jung et al.
Choa Yun et al.
Background: Infections may trigger autoimmunity, but large-scale studies on antibodies to infections and their associations with autoimmune diseases are limited. We aim to better understand the etiologic role of infection...
Integrative mass spectrometry-driven multi-omics and single cell technologies in ankylosing spondylitis: insights into pathogenesis, biomarker discovery, and precision medicine [0.03%]
整合质谱驱动的多组学和单细胞技术在强直性脊柱炎中的应用：对发病机制、生物标志物发现及精准医疗的新见解
Yan Gao,Xinge Li,Fengting Luo et al.
Yan Gao et al.
Ankylosing spondylitis (AS), a chronic inflammatory arthritis primarily affecting the axial skeleton, presents significant clinical challenges due to its complex pathogenesis, delayed diagnosis, and heterogeneous therapeutic responses. This...
Serum test for secretory component-containing anti-citrullinated protein antibodies as a novel prognostic tool in rheumatoid arthritis at-risk subjects [0.03%]
抗瓜氨酸蛋白抗体血清检测作为预测易感对象患类风湿性关节炎的新预后工具
Klara Martinsson,Simon Åhammar,Alexandra Cîrciumaru et al.
Klara Martinsson et al.
Individuals with autoantibodies against citrullinated proteins (ACPA) and musculoskeletal symptoms face increased risk of developing rheumatoid arthritis (RA). There are knowledge gaps concerning who will develop disease, and predictors of ...
Short-chain fatty acids from gut microbiota restore Th17/Treg balance in rheumatoid arthritis: Mechanisms and therapeutic potential [0.03%]
肠道菌群短链脂肪酸修复类风湿关节炎Th17/Treg失衡的机制及治疗潜力
Aimei Pang,Shuangshuang Pu,Yinghui Pan et al.
Aimei Pang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by synovial inflammation and joint destruction. Dysregulation of the Th17/Treg balance is a key immunological hallmark of RA. Emerging evidence highlights the critical...
Splicing-based biomarkers define a robust multigene classifier for relapsing-remitting multiple sclerosis [0.03%]
基于拼接的生物标志物定义了复发缓解型多发性硬化的稳健多基因分类器
Federica Airi,Valeria Rimoldi,Elvezia Maria Paraboschi et al.
Federica Airi et al.
Background: Alternative splicing (AS) is recognized as a key mechanism in multiple sclerosis (MS). We aimed to construct and validate a multivariate AS-based classifier (MS-Splicing Score, MS-SS) for the discrimination of...
Redefining multiple sclerosis therapy through microbial immunomodulation and epigenetic control [0.03%]
通过微生物免疫调节和表观遗传控制重新定义多发性硬化症治疗方案
Shan Xu,Christina James Thomas,Sunilgowda Sunnagatta Nagaraja et al.
Shan Xu et al.
Multiple sclerosis (MS) is a chronic autoimmune disorder marked by immune-driven demyelination and neurodegeneration in the central nervous system. This Review explores the immunological, molecular, and epigenetic underpinnings of MS, empha...