Expression of BAFF, APRIL, and cognate receptor genes in lupus nephritis and potential use as urinary biomarkers [0.03%]
系统性红斑狼疮肾炎中BAFF、APRIL及相应受体基因的表达及其作为尿液生物标志物的潜能
David Aguirre-Valencia,Lady J Ríos-Serna,Iván Posso-Osorio et al.
David Aguirre-Valencia et al.
Background: B-cell activating factor (BAFF), a proliferation-inducing ligand (APRIL), and their receptors BAFF-R, BCMA, and TACI are crucial factors for the survival of B lymphocytes. Recent evidence has also demonstrated...
Samantha Swain,Carlo Selmi,M Eric Gershwin et al.
Samantha Swain et al.
Selective IgA deficiency (SIgAD) is the most common primary immunodeficiency but does not always result in clinical disease. This may in part be due to the definition based on serum IgA, while most IgA is secreted at mucosal surfaces, not a...
Autoantibodies production and immunological abnormalities after bariatric surgery [0.03%]
减肥手术后的自身抗体生成及免疫异常
Gabriel J Tobón,Fabio E Ospina,Juan Pablo Suso et al.
Gabriel J Tobón et al.
Objective: Bariatric surgery is a widely used procedure for the treatment of obesity. Our aim is to describe the main immunological changes in patients who undergo bariatric surgery. ...
Autoantibodies against citrullinated serum albumin in patients with rheumatoid arthritis [0.03%]
类风湿性关节炎患者对瓜氨酸化血清白蛋白的自身抗体反应
Amanda Hefton,Shu Ying Liang,Kathryn Ni et al.
Amanda Hefton et al.
Rheumatoid arthritis (RA) is a chronic, potentially debilitating, inflammatory disease that primarily affects synovial joints. While the etiology of RA remains incompletely understood, it is clear that the disease is autoimmune in nature. A...
CD38-targeted therapy with daratumumab reduces autoantibody levels in multiple myeloma patients [0.03%]
达珠单抗针对CD38治疗可降低多发性骨髓瘤患者的自身抗体水平
Kristine A Frerichs,Christie P M Verkleij,Patricia W C Bosman et al.
Kristine A Frerichs et al.
Autoantibody-producing plasma cells are frequently resistant to conventional immunosuppressive treatments and B-cell depletion therapy. As a result of this resistance, autoreactive plasma cells survive conventional therapy, resulting in per...
The development of human immune system mice and their use to study tolerance and autoimmunity [0.03%]
人类免疫系统老鼠的发展及其用于研究耐受性和自免性疾病
Thiago Alves da Costa,Julie Lang,Raul M Torres et al.
Thiago Alves da Costa et al.
Autoimmune diseases evolve from complex interactions between the immune system and self-antigens and involve several genetic attributes, environmental triggers and diverse cell types. Research using experimental mouse models has contributed...
Polymyositis and dermatomyositis - challenges in diagnosis and management [0.03%]
多发性肌炎和皮肤炎性肌病 - 诊断和治疗的挑战
Shu-Han Yang,Christopher Chang,Zhe-Xiong Lian
Shu-Han Yang
Polymyositis (PM) and dermatomyositis (DM) are different disease subtypes of idiopathic inflammatory myopathies (IIMs). The main clinical features of PM and DM include progressive symmetric, predominantly proximal muscle weakness. Laborator...
The complement system in liver diseases: Evidence-based approach and therapeutic options [0.03%]
补体系统在肝脏疾病中的作用：基于证据的方法和治疗选择
Thomas Lung,Benjamin Sakem,Lorenz Risch et al.
Thomas Lung et al.
Complement is usually seen to largely originate from the liver to accomplish its tasks systemically - its return to the production site has long been underestimated. Recent progress in genomics, therapeutic effects on complement, standardis...
Subcutaneous abatacept in rheumatoid arthritis: A real-life experience [0.03%]
风湿性关节炎的皮下注射阿巴西普：实际体验报告
Juan Camilo Sarmiento-Monroy,Luisa Parada-Arias,Milena Rodríguez-López et al.
Juan Camilo Sarmiento-Monroy et al.
Objectives: To assess the effectiveness, safety, and drug survival of subcutaneous (SC) abatacept (ABA) in a cohort of rheumatoid arthritis (RA) patients in a real-world setting. ...
Yeny Acosta-Ampudia,Diana M Monsalve,Carolina Ramírez-Santana
Yeny Acosta-Ampudia
The target organ of neurological autoimmune diseases (NADs) is the central or peripheral nervous system. Multiple sclerosis (MS) is the most common NAD, whereas Guillain-Barré syndrome (GBS), myasthenia gravis (MG), and neuromyelitis optic...