Decreased HLA-DQ expression on peripheral blood cells in children with varying number of beta cell autoantibodies [0.03%]
不同类型β细胞自身抗体儿童外周血细胞HLA-DQ表达降低
Agnes Andersson Svärd,Marlena Maziarz,Anita Ramelius et al.
Agnes Andersson Svärd et al.
The risk for type 1 diabetes is strongly associated with HLA-DQ and the appearance of beta cell autoantibodies against either insulin, glutamate decarboxylase (GAD65), insulinoma-associated protein-2 (IA-2), or zinc transporter 8 (ZnT8). Pr...
MicroRNAs in ankylosing spondylitis: Function, potential and challenges [0.03%]
强直性脊柱炎中的microRNA：功能，潜力和挑战
Francesca Motta,Maria Cristina Carena,Carlo Selmi et al.
Francesca Motta et al.
Epigenetic mechanisms such as DNA methylation, histone modifications and non-coding RNA, are considered the essential connection between a disorder's onset and the environment, on a permissive genetic background. Among autoimmune and inflam...
Autoantibodies as biomarkers for interstitial lung disease in idiopathic inflammatory myositis and systemic sclerosis: The case of anti-eIF2B antibodies [0.03%]
自身抗体作为特发性炎症性肌病和系统性硬化症中肺间质疾病的生物标志物：以抗eIF2B抗体为例
Angela Ceribelli,Natasa Isailovic,Maria De Santis et al.
Angela Ceribelli et al.
Objectives: Serum autoantibodies are pivotal for the early detection of systemic autoimmune rheumatic diseases such as Systemic Sclerosis (SSc) and Poly/Dermatomyositis (PM/DM), and in some cases are associated with organ...
Antibody response to homologous epitopes of Epstein-Barr virus, Mycobacterium avium subsp. paratuberculosis and IRF5 in patients with different connective tissue diseases and in mouse model of antigen-induced arthritis [0.03%]
不同结缔组织疾病患者及抗原诱导性关节炎小鼠模型中针对Epstein-Barr病毒、Mycobacterium avium亚种paratuberculosis和IRF5同源表位的抗体反应
Marco Bo,Magdalena Niegowska,Hayley L Eames et al.
Marco Bo et al.
Background: Improved knowledge of different biomarkers is crucial for early diagnosis of rheumatic diseases and to provide important insights for clinical management. In this study, we evaluated the seroreactivity of pati...
Changyan Liu,Panpan Zhang,Wen Zhang
Changyan Liu
IgG4-related disease (IgG4-RD) is an immune-mediated inflammatory disorder in multiple organs, characterized by abundant infiltration of IgG4-positive plasmacytes and fibrosis in the involved organs. The precise pathogenic mechanism of IgG4...
Chen-Xing Zhang,Hui-Yu Wang,Lei Yin et al.
Chen-Xing Zhang et al.
Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by chronic inflammation and pathogenic auto-antibodies. Apart from B cells, dysregulation of other immune cells also plays an essential role in the pathogenesi...
Testing for IgA anti-tissue transglutaminase in routine clinical practice: Requesting behaviour in relation to prevalence of positive results [0.03%]
常规临床实践中IgA抗组织转谷氨酰胺酶的检测：阳性结果与申请行为的关系分析
Maurits Damoiseaux,William van Doorn,Ellen van Lochem et al.
Maurits Damoiseaux et al.
Objective: Due to the high awareness of coeliac disease and improvement of serological tests, the number of requested laboratory tests has increased substantially over the years. In the current study we have evaluated the...
Involvement of long noncoding RNAs in the pathogenesis of autoimmune diseases [0.03%]
长链非编码RNA在自身免疫疾病发病机制中的作用
Yaoyao Zou,Hanshi Xu
Yaoyao Zou
Autoimmune diseases are a group of heterogeneous disorders characterized by damage to various organs caused by abnormal innate and adaptive immune responses. The pathogenesis of autoimmune diseases is extremely complicated and has not yet b...
Trisomy X in a patient with childhood-onset systemic lupus erythematosus [0.03%]
三体X综合症在幼年发病系统性红斑狼疮患者中的表现
Fernanda B Barbosa,Nailu Angelica Sinicato,Paulo Rogério Julio et al.
Fernanda B Barbosa et al.
Childhood-onset systemic lupus erythematosus (cSLE) is a rare, chronic and systemic autoimmune disease generally with a more severe clinical phenotype than the adult-onset SLE. In both conditions, it is known that females are predominantly ...
Cristian C Aragón,Raúl-Alejandro Tafúr,Ana Suárez-Avellaneda et al.
Cristian C Aragón et al.
Systemic lupus erythematosus (SLE) is the prototypical autoimmune disease that can affect any organ of the body. Multiple mechanisms may contribute to the pathophysiology of systemic lupus, including failure to remove apoptotic bodies, hype...