Bcl-xL overexpression decreases GILZ levels and inhibits glucocorticoid-induced activation of caspase-8 and caspase-3 in mouse thymocytes [0.03%]
Bcl-xL过表达降低GILZ水平并抑制小鼠胸腺细胞中糖皮质激素诱导的caspase-8和caspase-3激活
Isabella Muscari,Sabrina Adorisio,Anna Marina Liberati et al.
Isabella Muscari et al.
Glucocorticoids promote thymocyte apoptosis and modulate transcription of numerous regulators of thymic apoptosis. Among these, glucocorticoid-induced leucine zipper (GILZ) is strongly upregulated in the thymus. We have previously demonstra...
[This corrects the article DOI: 10.1016/j.jtauto.2019.100016.][This corrects the article DOI: 10.1016/j.jtauto.2019.100021.][This corrects the article DOI: 10.1016/j.jtauto.2019.100025.][This corrects the article DOI: 10.1016/j.jtauto.2019....
Inflammatory monocyte-derived dendritic cells mediate autoimmunity in murine model of systemic lupus erythematosus [0.03%]
炎症单核来源的树突细胞介导了鼠系统性红斑狼疮模型中的自身免疫反应
Fumi Miyagawa,Yutaka Tagaya,Keiko Ozato et al.
Fumi Miyagawa et al.
Using a mouse model of systemic lupus erythematosus (SLE), we recently demonstrated that the two major manifestations of SLE are mechanistically independent because the type I IFN pathway leads to the autoantibody production whereas the NF-...
Family history of autoimmune disease in relation to time-to-pregnancy, pregnancy loss, and live birth rate [0.03%]
自身免疫疾病家族史与妊娠时间、流产及活产率的关系
Torie C Plowden,Matthew T Connell,Micah J Hill et al.
Torie C Plowden et al.
Several autoimmune conditions have adverse effects on reproductive outcomes, but the relationship between family history of autoimmune disease in women without these conditions and pregnancy is uncertain. The objective of this study was to ...
Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden [0.03%]
瑞典人群中格雷夫斯病和桥本甲状腺炎及其他自身免疫性疾病之间的家族风险研究
Hauke Thomsen,Xinjun Li,Kristina Sundquist et al.
Hauke Thomsen et al.
Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study w...
Aspartic acid70 in the HLA-DRB1 chain and shared epitope alleles partially explain the high prevalence of autoimmunity in Mexicans [0.03%]
HLA-DRB1链中的天冬氨酸70和共享表位等位基因部分解释了墨西哥人自身免疫的高发病率
Luis Francisco Valdés-Corona,Susana Hernández-Doño,Tatiana Sofia Rodríguez-Reyna et al.
Luis Francisco Valdés-Corona et al.
Introduction: Autoimmune thyroid disease (AITD) is the most common autoimmune disorder worldwide. Remarkably, it is commonly accompanied by other autoimmune diseases, such as rheumatoid arthritis (RA). The immunopathogeni...
Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes [0.03%]
贝赫切特病期间甘油磷脂代谢的失调导致循环单核细胞的促炎表型
Ana Mendes-Frias,Bruno Santos-Lima,Danielle Zildeana Sousa Furtado et al.
Ana Mendes-Frias et al.
Behçet's disease (BD) is a relapsing, multisystem and inflammatory condition characterized by systemic vasculitis of small and large vessels. Although the etiopathogenesis of BD remains unknown, immune-mediated mechanisms play a major role...
No evidence of autoimmunity to human OX1 or OX2 orexin receptors in Pandemrix-vaccinated narcoleptic children [0.03%]
接种了Pandemrix疫苗的嗜睡症儿童的人类OX1或OX2食欲肽受体自身免疫性的证据缺失
Krister Melén,Pinja Jalkanen,Jyrki P Kukkonen et al.
Krister Melén et al.
Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence...
Characterization of gut-homing molecules in non-endstage livers of patients with primary sclerosing cholangitis and inflammatory bowel disease [0.03%]
原发性硬化性胆管炎和炎症性肠病非终末期肝病患者肠道归巢分子的特征分析
Manon de Krijger,Thijmen Visseren,Manon E Wildenberg et al.
Manon de Krijger et al.
Introduction: The co-occurrence of inflammatory bowel disease (IBD) in up to 80% of patients with primary sclerosing cholangitis (PSC) suggests a relation between the gut and the liver in patients with both PSC and IBD. O...
The effect of sex on immune responses to a homocitrullinated peptide in the DR4-transgenic mouse model of Rheumatoid Arthritis [0.03%]
性别对DR4转基因鼠类风湿性关节炎模型中同型瓜氨酸化肽免疫反应的影响
Ewa Cairns,Sheri Saunders,David A Bell et al.
Ewa Cairns et al.
Rheumatoid Arthritis (RA) is more common and severe in women compared to men. Both women and men with RA express autoantibodies to post-translationally modified antigens, including citrullinated and homocitrullinated proteins or peptides. T...