Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4): Between immune tolerance and genetic predisposition to Systemic Lupus Erythematosus (SLE) [0.03%]
细胞毒性T淋巴细胞相关蛋白4（CTLA-4）：介于免疫耐受和系统性红斑狼疮（SLE）的遗传易感性之间
Hajar Fadili,Mohammed Fahi,Abire Allaoui et al.
Hajar Fadili et al.
Gábor Nagy,Dóra Bencze,Sarolta Demeter et al.
Gábor Nagy et al.
Autoimmune hepatitis (AIH) is a rare, chronic, immune mediated liver disorder with unknown origin, associated with elevation of serum transaminases and IgG, positivity of certain autoantibodies and characteristic histopathological alteratio...
Autoantibodies in the diagnostics, prognostics and follow-up of primary biliary cholangitis [0.03%]
自身抗体在原发性胆汁性胆管炎诊断、预后和随访中的应用
Péter Antal-Szalmás,Dóra Bencze,Sarolta Demeter et al.
Péter Antal-Szalmás et al.
Primary biliary cholangitis (PBC), is a chronic autoimmune liver disease, characterized by cholangiopathy, cholestasis and in the long-term fibrosis, biliary cirrhosis and ultimately end-stage liver disease unless liver transplantation is a...
Ruxolitinib reverses alopecia areata via a triple mechanism: JAK-STAT inhibition, localized oxidative stress attenuation and selective apoptosis modulation [0.03%]
鲁索利替尼通过三联机制逆转斑秃：JAK-STAT抑制、局部抗氧化和选择性凋亡调控
Meiling Zhu,Hao Mu,Bo Wang et al.
Meiling Zhu et al.
Alopecia areata (AA) is an autoimmune hair loss disorder driven by the IFN-γ-JAK-STAT signaling and cytotoxic T-cell attack. Although JAK inhibitors like ruxolitinib show clinical efficacy, their integrated mechanism remains unclear. This ...
Machine learning for predicting macrophage activation syndrome in adult patients with Still's disease [0.03%]
用于预测成人Still病患者macrophage激活综合征的机器学习方法
Yihe Zheng,Changyi Yang,Xiaoxuan Cai et al.
Yihe Zheng et al.
Background: Macrophage activation syndrome (MAS) secondary to Still's disease is a potentially fatal complication, associated with mortality rates exceeding 10%. Early identification is critical for survival but remains c...
Persistent cutaneous lupus erythematosus: A pathway toward systemic disease? [0.03%]
持久性盘状红斑狼疮：向系统性疾病发展的途径？
Qi Wang,Mengjiao Chen,Hui Jin et al.
Qi Wang et al.
Cutaneous lupus erythematosus (CLE) is an inflammatory autoimmune disease characterized by specific skin lesions, differing from systemic lupus erythematosus (SLE) which affects multiple organs widely. Although CLE has traditionally been re...
A novel epigenetic regulation of JAM-A by EZH2-DNMT3A cascade contributes to T cell adhesion via the activation of Rap1a in lupus patients [0.03%]
EZH2-DNMT3A信号通路表观遗传学调节JAM-A的新机制在系统性红斑狼疮患者中促进T细胞活化及粘附
Lei Ding,Huan Gu,Yuting Zhong et al.
Lei Ding et al.
Objectives: The peripheral blood T cells epigenetic modification and adhesion capacity alterations are the characteristic of SLE. EZH2 induces proinflammatory epigenetic changes in immune regulation. JAM-A widely involves...
Intrathecal immunoglobulin production in the diagnosis, prognosis, and monitoring of autoimmune diseases of the central nervous system [0.03%]
免疫球蛋白的脑脊液内产生在中枢神经系统自身免疫性疾病的诊断、预后和监测中的作用
Yves Renaudineau,Bénédicte Puissant-Lubrano
Yves Renaudineau
Intrathecal immunoglobulin production is a hallmark of central nervous system (CNS) inflammation and can be observed in autoimmune disorders of the CNS, primarily multiple sclerosis (MS), but also in other inflammatory conditions such as MO...
Soluble immune checkpoints reflect immune activation and treatment response in high-risk systemic sclerosis patients treated with plasma exchange [0.03%]
血浆置换治疗高危系统性硬化病患者的可溶性免疫检查点反映免疫激活和治疗反应
Judith Potjewijd,Rachid Tobal,Daan P C van Doorn et al.
Judith Potjewijd et al.
Introduction: Systemic sclerosis (SSc) is an autoimmune disease characterized by immune dysregulation, vasculopathy, and fibrosis. High-risk patients, particularly those with diffuse cutaneous involvement (dcSSc) and inte...
GRN and KLRB1 define a shared peripheral-blood transcriptomic signature linking SLE and IPF [0.03%]
GRN和KLRB1定义了一个共享的外周血转录特征，把SLE和IPF联系起来
Lijun Pang,Yunfei Li,Junjie Chen et al.
Lijun Pang et al.
Background: Systemic lupus erythematosus (SLE) and idiopathic pulmonary fibrosis (IPF) share immune-inflammatory features, yet their convergent peripheral-blood transcriptomic signatures remain incompletely defined. We so...