Ancient friends, revisited: Systematic review and case report of pyoderma gangrenosum-associated autoinflammatory syndromes [0.03%]
旧友重逢：关于化脓性肉芽肿性皮病相关自身炎症综合征的系统评价与病例报告
Roman Saternus,Jérôme Schwingel,Cornelia S L Müller et al.
Roman Saternus et al.
In the last decade, new scientific findings significantly improved our understanding of the molecular pathogenesis of autoinflammation and have resulted in the identification and definition of several pyoderma gangrenosum-associated autoinf...
Breakdown of T-cell ignorance: The tolerance failure responsible for mainstream autoimmune diseases? [0.03%]
T细胞无能的瓦解：导致自身免疫性疾病的耐受失败？
Myer R Salaman,Keith G Gould
Myer R Salaman
This article explores the possibility that the major autoimmune diseases come about because of the breakdown of T lymphocyte ignorance - that state in which antigen and lymphocyte have never come together in such a way as to induce toleranc...
Prevalence of autoantibody responses in acute coronavirus disease 2019 (COVID-19) [0.03%]
急性冠状病毒疾病(COVID-19)自身抗体反应的流行率
L Angelica Lerma,Anu Chaudhary,Andrew Bryan et al.
L Angelica Lerma et al.
Immunopathology may play a significant role in the pathogenesis of Coronavirus-Induced Disease-19 (COVID-19). Immune-mediated tissue damage could result from development of rapid autoimmune responses, characterized by production of self-rea...
Serological comparison of systemic lupus erythematosus with neuropsychiatric lupus using synthetic nucleic acid antigens [0.03%]
使用合成核酸抗原对系统性红斑狼疮与神经精神狼疮进行血清学比较研究
Sangita Khatri,Nikos Psaraftis,Alessia Funaro et al.
Sangita Khatri et al.
Neuropsychiatric systemic lupus erythematosus is an autoimmune disorder characterized by an irregular exchange between the central nervous system and the immune system, leading to the outbreak of neurological conditions with possible disabl...
Why will it never be known if convalescent plasma is effective for COVID-19 [0.03%]
恢复期血浆疗法真的对COVID-19无效吗？遗憾的是我们可能无法下定论
Manuel Rojas,Juan-Manuel Anaya
Manuel Rojas
High expectations have been set around convalescent plasma (CP) for the treatment of COVID-19. However, none of the randomized controlled trials (RCTs) conducted so far have reached their primary endpoints. Herein we report that RCTs of CP ...
In-depth characterization of the biomarkers based on tumor-infiltrated immune cells reveals implications for diagnosis and prognosis in hepatocellular carcinoma [0.03%]
基于肿瘤浸润免疫细胞的生物标志物的深入特征揭示了其在肝细胞癌诊断和预后中的意义
Wenbiao Chen,Kefan Bi,Xujun Zhang et al.
Wenbiao Chen et al.
Hepatocellular carcinoma (HCC) is an immune-related tumor, that the type and number of tumor-infiltrated immune cells can serve as biomarkers for the clinical application. In this study, we constructed the immune model for diagnostic and pr...
Maria Ines Ramos,Samuel Garcia,Boy Helder et al.
Maria Ines Ramos et al.
Rheumatoid arthritis (RA) is chronic autoimmune disease which etiology remains unknown. Several cell types have been described to potentiate/aggravate the arthritic process however the initiating event in synovial inflammation is still elus...
Axenic Caenorhabditis elegans antigen protects against development of type-1 diabetes in NOD mice [0.03%]
无菌的秀丽隐杆线虫抗原可阻止NOD小鼠发展为1型糖尿病
Belinda M Jackson-Thompson,Marina Torrero,Blima K Mitre et al.
Belinda M Jackson-Thompson et al.
Studies in humans and animals have demonstrated that infection with helminths (parasitic worms) is protective against a range of hyperinflammatory diseases. A number of factors limit translation into clinical use, including: potential conta...
Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus [0.03%]
识别人体胸腺中自然表达的组织限制性抗原的人类T细胞的负选择
Rachel Madley,Grace Nauman,Nichole Danzl et al.
Rachel Madley et al.
During T cell development in mice, thymic negative selection deletes cells with the potential to recognize and react to self-antigens. In human T cell-dependent autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid...
Donna Kruger,Praveen Prathapan
Donna Kruger
The Strategic Plan for Biodefense Research by the U.S. Department of Health and Human Services demarcates the need for drugs which target multiple types of pathogens to prepare for infectious threats. Azithromycin is one such broad-spectrum...