Disruption of CCR5 signaling to treat COVID-19-associated cytokine storm: Case series of four critically ill patients treated with leronlimab [0.03%]
CCR5信号通路紊乱可治疗COVID-19相关细胞因子风暴：4例使用勒罗尼姆阿布治疗的危重患者系列报道
Nicholas Agresti,Jacob P Lalezari,Phillip P Amodeo et al.
Nicholas Agresti et al.
Coronavirus disease 2019 (COVID-19) is associated with considerable morbidity and mortality. The number of confirmed cases of infection with SARS-CoV-2, the virus causing COVID-19 continues to escalate with over 70 million confirmed cases a...
Increased intestinal permeability in primary Sjögren's syndrome and multiple sclerosis [0.03%]
原发性舍格伦综合征和多发性硬化症中肠道通透性的增加
Bitte Sjöström,Anders Bredberg,Thomas Mandl et al.
Bitte Sjöström et al.
There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, wh...
Complex regional pain syndrome - Autoimmune or functional neurologic syndrome [0.03%]
复杂性区域疼痛综合征-自身免疫性疾病还是功能性神经症？
Christopher Chang,Patrick McDonnell,M Eric Gershwin
Christopher Chang
Complex regional pain syndrome (CRPS) purports to explain extremity pain accompanied by a variety of subjective complaints, including sensitivity to touch, fatigue, burning sensations, allodynia and signs consistent with voluntary immobiliz...
NRF2 activator A-1396076 ameliorates inflammation in autoimmune disease models by inhibiting antigen dependent T cell activation [0.03%]
NRF2激活剂A-1396076通过抑制抗原依赖的T细胞活化改善自身免疫病模型中的炎症反应
Christian Goess,Sonia Terrillon,Martha Mayo et al.
Christian Goess et al.
Nuclear factor (erythroid-derived 2) like 2 (NRF2) is a nuclear transcription factor activated in response to oxidative stress that induces a gene program that dampens inflammation and can limit cell damage that perpetuates the inflammatory...
Bacterial infections in lupus: Roles in promoting immune activation and in pathogenesis of the disease [0.03%]
系统自动摘要：细菌感染在狼疮中的作用：促进免疫活化和疾病发病机制的作用
Michael Battaglia,Lee Ann Garrett-Sinha
Michael Battaglia
Background: Bacterial infections of the lung, skin, bloodstream and other tissues are common in patients with systemic lupus erythematosus (lupus) and are often more severe and invasive than similar infections in control ...
IgG4-related disease: Changing epidemiology and new thoughts on a multisystem disease [0.03%]
IgG4相关疾病：多系统疾病的流行病学变化及新认识
Annarosa Floreani,Kazuichi Okazaki,Kazushige Uchida et al.
Annarosa Floreani et al.
IgG4-related disease (IgG4-RD) represents an immune-mediated fibroinflammatory condition with peculiar histopathologic changes that can affect various organs. In 2012 its unified nomenclature was published, which allows to abandon other syn...
Ehlers-Danlos Syndrome: Immunologic contrasts and connective tissue comparisons [0.03%]
埃勒斯-丹洛斯综合征：免疫学对比与结缔组织比较
Mareesa Islam,Christopher Chang,M Eric Gershwin
Mareesa Islam
Ehlers-Danlos Syndrome (EDS) is a family of multisystemic hereditary connective tissue disorders now comprised of 13 recognized subtypes, classical, classical-like, cardiac-valvular, vascular, hypermobile, arthrochlasia, dermosparaxis, kyph...
Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice [0.03%]
非自身免疫小鼠和系统性红斑狼疮小鼠中体内外源性B细胞受体和Fcγ受体IIb共刺激后B细胞活化的抑制作用研究
Seung Y Chu,Erik Pong,Christine Bonzon et al.
Seung Y Chu et al.
Engagement of Fcγ receptor IIb (FcγRIIb) suppresses B cell activation and represents a promising target for therapy in autoimmunity. Obexelimab is a non-depleting anti-human CD19 mAb with an Fc region engineered to have high affinity for ...
Biomedical applications of snake venom: from basic science to autoimmunity and rheumatology [0.03%]
毒蛇毒液的生物医学应用：从基础研究到自身免疫和风湿病学
Carlos A Cañas,Santiago Castaño-Valencia,Fernando Castro-Herrera et al.
Carlos A Cañas et al.
Snake venoms have components with diverse biological actions that are extensively studied to identify elements that may be useful in biomedical sciences. In the field of autoimmunity and rheumatology, various findings useful for the study o...
Treatment strategy introducing immunosuppressive drugs with glucocorticoids ab initio or very early in giant cell arteritis: A multicenter retrospective controlled study [0.03%]
初诊或早期诊断大动脉炎即使用糖皮质激素联合免疫抑制剂治疗策略的多中心回顾性研究
Luca Quartuccio,Miriam Isola,Dario Bruno et al.
Luca Quartuccio et al.
Objective: Glucocorticoids (GC) are associated with side effects in giant cell arteritis (GCA). Immunosuppressive therapies (ITs) have given conflicting results in GCA, regarding GC sparing effect. Primary endpoint is to ...