Case study of a critically ill person with COVID-19 on ECMO successfully treated with leronlimab [0.03%]
一例接受ECMO治疗的重症COVID-19患者成功使用勒那利姆单抗案例分析
Sohier Elneil,Jacob P Lalezari,Nader Z Pourhassan
Sohier Elneil
The number of confirmed cases of infection with SARS-CoV-2, the virus causing Coronavirus disease 2019 (COVID-19), continues to increase and is associated with substantial morbidity and mortality in virtually every country in the world. Alt...
In vitro and ex vivo functional characterization of human HLA-DRB1∗04 restricted T cell receptors [0.03%]
人HLA-DRB1∗04限制性T细胞受体在体外和离体的功能表征
Sanjaykumar V Boddul,Ravi Kumar Sharma,Anatoly Dubnovitsky et al.
Sanjaykumar V Boddul et al.
Recent advances in single-cell sequencing technologies enable the generation of large-scale data sets of paired TCR sequences from patients with autoimmune disease. Methods to validate and characterize patient-derived TCR data are needed, a...
S95021, a novel selective and pan-neutralizing anti interferon alpha (IFN-α) monoclonal antibody as a candidate treatment for selected autoimmune rheumatic diseases [0.03%]
新型选择性及广谱中和干扰素α（IFN-α）单克隆抗体S95021可作为某些自身免疫风湿病治疗的候选药物
Fanny Duguet,Céline Ortega-Ferreira,Benjamin Fould et al.
Fanny Duguet et al.
Increased interferon-α (IFN-α) production is a critical component in the pathophysiology of systemic lupus erythematosus (SLE) and other rheumatic autoimmune diseases. Herein, we report the characterization of S95021, a fully human IgG1 a...
Difference of IFI44L methylation and serum IFN-a1 level among patients with discoid and systemic lupus erythematosus and healthy individuals [0.03%]
IFIK44L甲基化及血清干扰素α1水平在盘状红斑狼疮、系统性红斑狼疮和健康人中的差异分析
Bo Zhang,Tian Zhou,Haijing Wu et al.
Bo Zhang et al.
Lupus erythematosus (LE) is an autoimmune disease that can be divided into two types. The cutaneous lupus erythematosus (CLE), such as discoid LE (DLE), affects only the skin. While the systemic lupus erythematosus (SLE) affects the hematop...
Proinsulin:C-peptide ratio trajectories over time in relatives at increased risk of progression to type 1 diabetes [0.03%]
高风险的一级亲属进展为1型糖尿病的胰岛素原C肽比率变化轨迹分析
Taylor M Triolo,Laura Pyle,Sona Seligova et al.
Taylor M Triolo et al.
Objective: Biomarkers are needed to characterize heterogeneity within populations at risk for type 1 diabetes. The ratio of proinsulin to C-peptide (PI:C ratio), has been proposed as a biomarker of beta cell dysfunction a...
Latent rheumatic, thyroid and phospholipid autoimmunity in hospitalized patients with COVID-19 [0.03%]
住院COVID-19患者的潜在风湿、甲状腺和磷脂自身免疫反应
Juan-Manuel Anaya,Diana M Monsalve,Manuel Rojas et al.
Juan-Manuel Anaya et al.
Autoimmune responses mediated by autoantibodies have been observed in SARS-CoV-2 infection. Herein, we evaluate the presence of rheumatic, thyroid and phospholipid autoantibodies in sera samples from 120 adult hospitalized patients with COV...
What is the evidence that mycobacteria are associated with the pathogenesis of Sjogren's syndrome? [0.03%]
关于结核分枝杆菌与舍格伦综合征发病机制相关的证据有哪些？
Coad Thomas Dow,Edward D Chan
Coad Thomas Dow
Sjogren's syndrome (SS) is a common, systemic autoimmune disorder primarily affecting the exocrine glands resulting in xerostomia and xerophthalmia. SS may also manifest with polyarthralgia, polyarthritis, polymyalgia, cutaneous/other organ...
Benefits of early aggressive immunomodulatory therapy (tocilizumab and methylprednisolone) in COVID-19: Single center cohort study of 685 patients [0.03%]
托珠单抗和甲基泼尼松龙早期强化免疫治疗在COVID-19患者中的疗效：一项单中心队列研究(685例患者)
Buzon-Martín Luis,Montero-Baladía Miguel,Delgado-López Pedro et al.
Buzon-Martín Luis et al.
Introduction: A growing evidence suggests that immune dysregulation and thrombotic phenomena are key features in the pathophysiology of COVID-19. Apart from antivirals and respiratory support, anticoagulants, corticoids a...
Quality of life in patients with primary biliary cholangitis: A cross-geographical comparison [0.03%]
原发性胆汁性胆管炎患者的生存质量：跨地域对比研究
Lorenzo Montali,Andrea Gragnano,Massimo Miglioretti et al.
Lorenzo Montali et al.
Background & aims: Several symptoms impair the quality of life (QoL) of patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim of our study was to explore whet...
Characteristics of COVID-19 infection and antibody formation in patients known at a tertiary immunology department [0.03%]
在一家三级免疫学部门已知的新冠感染患者的新冠病毒感染特征及抗体形成特点
Niels A D Guchelaar,Jan A M van Laar,Maud A W Hermans et al.
Niels A D Guchelaar et al.
Background: Knowledge about COVID-19 infections is expanding, although knowledge about the disease course and antibody formation in patients with an auto-immune disease or immunodeficiency is not fully unraveled yet. It c...