NKTR-358: A novel regulatory T-cell stimulator that selectively stimulates expansion and suppressive function of regulatory T cells for the treatment of autoimmune and inflammatory diseases [0.03%]
NKTR-358：一种新型调节性T细胞刺激剂，可选择性地刺激调节性T细胞的扩增和抑制功能，用于自身免疫和炎症性疾病的治疗
Neha Dixit,Christie Fanton,John L Langowski et al.
Neha Dixit et al.
Impaired interleukin-2 (IL-2) production and regulatory T-cell dysfunction have been implicated as immunological mechanisms central to the pathogenesis of multiple autoimmune and inflammatory diseases. NKTR-358, a novel regulatory T-cell st...
Bortezomib treatment for refractory nontuberculous mycobacterial infection in the setting of interferon gamma autoantibodies [0.03%]
干扰素γ自身抗体阳性相关的难治性非结核分枝杆菌感染的硼替佐米治疗
Joseph M Rocco,Lindsey B Rosen,Gloria H Hong et al.
Joseph M Rocco et al.
Interferon-γ autoantibodies increase the risk of disseminated nontuberculous mycobacterial infections. Addition of rituximab to antibiotics accelerates and improves outcomes, but refractory infections can occur due to persistent production...
Persisting symptoms in patients with Hashimoto's disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review [0.03%]
桥本病患者的持续性临床症状与其甲状腺自身免疫有关吗？系统评价
Karelina L Groenewegen,Christiaan F Mooij,A S Paul van Trotsenburg
Karelina L Groenewegen
Objective: Patients with hypothyroidism due to Hashimoto's disease (HD) may experience persisting symptoms despite normal serum thyroid hormone (TH) levels. Several hypotheses have been postulated to explain these persist...
Successful treatment of ulcerated pyoderma gangrenosum with baricitinib, a novel JAK inhibitor [0.03%]
巴瑞克替尼治疗溃疡型坏死性瘭疽的疗效观察：一种新型JAK抑制剂
Morton Scheinberg,Luis Antônio Machado,Luiz Guilherme M Castro et al.
Morton Scheinberg et al.
Pyoderma gangrenosum manifests as an ulceration of the skin often associated with several systemic diseases. The diagnosis is usually made by exclusion criteria with suggestions made by clinical findings and histological features. It can oc...
Pathogenesis and pathology of anti-neutrophil cytoplasmic antibody（ANCA）-associated vasculitis [0.03%]
抗中性粒细胞胞浆抗体(ANCA)相关性血管炎的发病机制和病理学特点
Daisuke Tsukui,Yoshitaka Kimura,Hajime Kono
Daisuke Tsukui
•AAV is characterized by necrotizing small vessel vasculitis with positive serum ANCA.•MPO/PR3-ANCA and neutrophils play central roles in AAV pathogenicity.•Dysregulated complement system primes neutrophils.•MPO-ANCA directly activates ...
Predicted regulatory SNPs reveal potential drug targets and novel companion diagnostics in psoriasis [0.03%]
预测性调节型SNP的发现可揭示银屑病潜在药物靶点及新型伴随诊断指标
Andrea Virginia Ruiz Ramírez,Adolfo Flores-Saiffe Farías,Rocío Del Carmen Chávez Álvarez et al.
Andrea Virginia Ruiz Ramírez et al.
Psoriasis is an autoimmune disease associated with interleukins, their receptors, key transcription factors and more recently, antimicrobial peptides (AMPs). Cathelicidin LL-37 is an AMP proposed to play a fundamental role in psoriasis etio...
Ingrid Ruiz-Ordoñez,Juan-Manuel Piedrahita,Javier-Andrés Arévalo et al.
Ingrid Ruiz-Ordoñez et al.
Sjögren's syndrome (SS) is a systemic autoimmune disease characterised by a wide range of clinical manifestations and complications, including B-cell lymphoma. This study aims to describe the predictors associated with lymphomagenesis in p...
Functional autoantibodies against G-protein coupled receptors in patients with persistent Long-COVID-19 symptoms [0.03%]
长期新冠患者的G蛋白偶联受体功能性自身抗体研究
Gerd Wallukat,Bettina Hohberger,Katrin Wenzel et al.
Gerd Wallukat et al.
Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to t...
Chronic nonbacterial osteomyelitis (CNO) and chronic recurrent multifocal osteomyelitis (CRMO) [0.03%]
慢性非细菌性骨髓炎(CNO)和复发性多发性骨髓炎(CRMO)
Dan Yongdong Zhao,Liza McCann,Gabriele Hahn et al.
Dan Yongdong Zhao et al.
Chronic nonbacterial osteomyelitis (CNO) is an inflammatory bone disorder that most frequently affects children and adolescents. Chronic recurrent multifocal osteomyelitis (CRMO) is a severe form of CNO, usually characterized by symmetrical...
An elevated polyclonal free light chain level reflects a strong interferon signature in patients with systemic autoimmune diseases [0.03%]
全身自身免疫病患者中升高的是多克隆游离轻链反映强烈的干扰素特征
Eléonore Bettacchioli,Christelle Le Gaffric,Margaux Mazeas et al.
Eléonore Bettacchioli et al.
High amount of polyclonal free light chains (FLC) are reported in systemic autoimmune diseases (SAD) and we took advantage of the PRECISESADS study to better characterize them. Serum FLC levels were explored in 1979 patients with SAD (RA, S...