Type I interferon-dependent and -independent signaling underlie autoantibody production in a murine lupus model [0.03%]
I型干扰素依赖和非依赖信号转导参与小鼠狼疮模型自身抗体的产生
Jerrold S Levine,Céleste Pilon,Rebecca Subang et al.
Jerrold S Levine et al.
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies against diverse self-antigens and damage to multiple organs. Immunization with the SLE autoantigen β2-glycoprotein I and lipopolysaccharide (LPS) indu...
How loss-of-function mutations in IFIH1 contribute to infectious and/or inflammatory disease - a systematic review [0.03%]
IFIH1失活突变体对感染和/或炎症疾病影响的系统性综述研究
Isabelle Ince,Francesca Sposito,Amandine Charras et al.
Isabelle Ince et al.
The IFIH1 gene encodes for the cytoplasmic innate immune receptor Melanoma Differentiation-Associated protein 5 (MDA5) that detects viral double-stranded RNA to initiate type I interferon (IFN) responses. While gain-of-function mutations in...
Antinuclear antibody targets in autoimmune hepatitis and drug-induced liver injury: Diagnostic relevance of nucleosome antibodies [0.03%]
自身免疫性肝炎和药物性肝损伤中的抗核抗体靶点及组蛋白-小体抗体的诊断意义
Mirjam Kolev,Michèle Freiburghaus,Guido Stirnimann et al.
Mirjam Kolev et al.
Background & aims: Anti-nuclear antibodies (ANA) are detected in 70-100 % of patients with autoimmune hepatitis (AIH) and in 22-33 % of patients with drug-induced liver injury (DILI). However, little is known about the sp...
Female cancer incidence before and after diagnosis of primary Sjögren's disease: A retrospective cohort study [0.03%]
原发性舍格伦综合征诊断前后女性癌症发病率：一项回顾性队列研究
Bitte Sjöström,Anders Bredberg,Peter Olsson et al.
Bitte Sjöström et al.
In primary Sjögren's disease (pSjD), there is a well-documented increased risk of hematological malignancies, particularly lymphomas, whereas studies examining the incidence of solid tumors have often yielded conflicting results. Data conc...
Liraglutide prevents lupus-associated diffuse alveolar hemorrhage via inhibiting lymphocyte infiltration and promoting macrophage M2 polarization [0.03%]
利拉鲁肽通过抑制淋巴细胞浸润和促进巨噬细胞M2极化来预防系统性红斑狼疮相关弥漫性肺泡出血
Li Jiang,Liting He,Duo Li et al.
Li Jiang et al.
Objectives: This study aimed to explore the prophylactic and therapeutic role of liraglutide for lupus-associated diffuse alveolar hemorrhage (DAH). Metho...
Downregulated ECHS1 and HADH-mediated fatty acid β-oxidation contributes to mitochondrial dysfunction in salivary glands of Sjögren's syndrome [0.03%]
腮腺ECHS1和HADH介导的脂肪酸β氧化下调导致舍格伦综合征线粒体功能障碍
Min Zhou,Yu Liu,Jinxia He et al.
Min Zhou et al.
Background: Sjögren's syndrome (SS) is a common autoimmune disease characterized clinically by dry mouth and dry eyes resulting from impaired exocrine gland function. However, its precise pathogenesis remains incompletel...
Immunoprotective and neuroprotective properties of gut microbiome in psoriasis [0.03%]
肠菌在银屑病免疫保护和神经保护特性中的作用
Amirhesan Yahyapour,Ali Najafi,Ali Ahmadi et al.
Amirhesan Yahyapour et al.
Psoriasis impacts nearly 100 million people globally and is associated with neuropsychiatric comorbidities such as depression and anxiety. With gut microbiome dysbiosis serving as a primary pathophysiological factor, the gut-brain-skin axis...
Systemic lupus pregnancies are characterized by an intrinsic pro-inflammatory monocyte transcriptome, driven by an aberrant miRNA signature [0.03%]
系统性红斑狼疮妊娠具有固有促炎单核细胞转录组特征，由异常的微小RNA谱型驱动
Marc Scherlinger,Eloi Schmauch,Raphaël Carapito et al.
Marc Scherlinger et al.
Objective: Pregnancy induces profound immunological adaptations that usually promote tolerance and reduce autoimmune activity. However, women with systemic lupus erythematosus (SLE) remain at increased risk of disease fla...
Identifying subtype-specific molecular pathways in Crohn's disease through RNA-seq and protein-protein interaction network analysis [0.03%]
基于RNA测序和蛋白质相互作用网络分析识别克罗恩病亚型特异性分子通路
Sree Ishan Kolukula
Sree Ishan Kolukula
Crohn's Disease (CD) is a chronic autoinflammatory disease of the gastrointestinal tract. Anatomical labels like Ileal Crohn's Disease (ICD) and Colonic Crohn's Disease (CCD) do not capture the molecular heterogeneity which contributes to t...
T cell proliferative response to a homocitrullinated peptide correlates with joint pathology in collagen induced arthritis [0.03%]
同蛋鸡卵白诱导性关节炎中，T细胞增殖反应与同蛋鸡卵白多肽相关的关节病理变化相关性研究
Jaspreet Kaur,Sofya Ulanova,Ewa Cairns et al.
Jaspreet Kaur et al.
Rheumatoid arthritis (RA) is characterized by autoimmune responses against citrullinated and homocitrullinated proteins/peptides (CitP and HomoCitP respectively), resulting in joint pain, inflammation, and damage. Although the collagen indu...