Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus [0.03%]
自身抗体与系统性红斑狼疮患者的IFN信号和NETosis的关系
Ellen D Kaan,Tammo E Brunekreef,Julia Drylewicz et al.
Ellen D Kaan et al.
Objective: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a variety of disease symptoms and an unpredictable clinical course. To improve treatment outcome, stratification based on immunologic...
To switch or to swap? Evidence from a meta-analysis for the best treatment approach in childhood chronic uveitis resistant to the I anti-TNF [0.03%]
switching还是 swapping？儿童慢性uveitis对I抗-TNF治疗抵抗的最佳治疗方案的meta分析证据
Ilaria Maccora,Sara Soldovieri,Teodoro Oliverio et al.
Ilaria Maccora et al.
Objective: Since adalimumab approval in childhood chronic non-infectious uveitis (cNIU), the prognosis has been dramatically changed, but the 25 % failed to achieve inactivity. There is not accordance if it is better to s...
Yves Renaudineau
Yves Renaudineau
The new era of immune skin diseases: Exploring advances in basic research and clinical translations [0.03%]
免疫皮肤病的新时代：探索基础研究和临床转化的进展
Bo Zhang,Xiaole Mei,Ming Zhao et al.
Bo Zhang et al.
Urinary soluble CD163 is useful as "liquid biopsy" marker in lupus nephritis at both diagnosis and follow-up to predict impending flares [0.03%]
可溶性CD163作为系统性红斑狼疮肾炎诊断及预后"液体活检"标志物的意义
Yves Renaudineau,Dominique Chauveau,Stanislas Faguer et al.
Yves Renaudineau et al.
Lupus nephritis (LN) diagnosis and follow-up requires noninvasive biomarkers. Therefore, the added value of coupling the urinary soluble (s)CD163/creatinuria ratio with serological markers was evaluated in a real-world clinical practice. To...
PNPLA3 I148 M genetic variant in autoimmune hepatitis characterises advanced disease at diagnosis and reduced survival free of cirrhotic events and liver-related mortality [0.03%]
自身免疫性肝炎中PNPLA3 I148M遗传变异的特点是在诊断时病情较重并且减少了非肝硬化事件和肝病相关死亡的生存率
Kalliopi Azariadis,Nikolaos K Gatselis,Aggeliki Lyberopoulou et al.
Kalliopi Azariadis et al.
Background: Autoimmune hepatitis (AIH) is a relatively rare autoimmune disease with a strong genetic background. The patatin-like phospholipase domain-containing protein 3 (PNPLA3) I148 M (rs738409 C/G) variant has been a...
Triptolide regulates neutrophil function through the Hippo signaling pathway to alleviate rheumatoid arthritis disease progression [0.03%]
三醇通过调节嗜中性粒细胞的功能（即Hippo信号通路）来缓解类风湿关节炎的发展进程
Pengyuan Liu,Huiyang Liu,Yali Sang et al.
Pengyuan Liu et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammatory changes in the joints, the etiology of which is unclear. It is now well established that regulated cell death (RCD) and migration of neutrophils play an...
Maryam Zare Moghaddam,Mohammad Javad Mousavi,Somayeh Ghotloo
Maryam Zare Moghaddam
Systemic lupus erythematosus (SLE), an autoimmune disease, is among the most prevalent rheumatic autoimmune disorders. It affects autologous connective tissues caused by the breakdown of self-tolerance mechanisms. During the last two decade...
Changes upon the gluten-free diet of HLA-DQ2 and TRAFD1 gene expression in peripheral blood of celiac disease patients [0.03%]
无麸胶饮食对乳糜泻患者外周血HLA-DQ2和TRAFD1基因表达的影响研究
Mariavittoria Laezza,Laura Pisapia,Benedetta Toro et al.
Mariavittoria Laezza et al.
Background: Celiac disease (CD) is a chronic immuno-mediated enteropathy caused by dietary gluten in genetically susceptible individuals carrying HLA (Human Leukocytes Antigen) genes that encode for DQ2.5 and DQ8 molecule...
Autoantibodes to GP210 are a metric for UDCA responses in primary biliary cholangitis [0.03%]
抗GP210自身抗体是原发性胆汁性肝硬化患者对熊去氧胆酸治疗反应的预测指标
Chan Wang,Zhuye Qin,Mingming Zhang et al.
Chan Wang et al.
Objectives: Antibodies to gp210 and sp100 are specific and unique anti-nuclear autoantibodies (ANAs) associated with primary biliary cholangitis (PBC). Importantly the presence of anti-gp210 and anti-sp100 responses is in...