Autoimmune diseases and cardiovascular risk: Mendelian randomization analysis for the impact of 19 autoimmune diseases on 14 cardiovascular conditions [0.03%]
自身免疫性疾病与心血管风险：遗传随机化分析评估19种自身免疫疾病对14种心血管状况的影响
Yulin Bao,Lingfeng Gu,Jiayi Chen et al.
Yulin Bao et al.
Backgroud: Autoimmune diseases (AIDs) have been associated with various cardiovascular diseases (CVDs) in observational data. However, the causality of these associations remains uncertain. Therefore, a systematic assessm...
Nelly Candela,Nicolas Benichou,Mathilde Lefebvre et al.
Nelly Candela et al.
Objective: To compare the natural history of C3 glomerulopathy (C3G) to acute post-infectious glomerulonephritis (APIGN) in a cohort of patients with a relative homogeneity of environment conditions and genetic background...
Homeostatic signals, including IL-7 and self-MHC recognition, induce the development of peripheral helper T cells, which are enriched in the joints of rheumatoid arthritis [0.03%]
稳态信号（包括IL-7和自身MHC识别）诱导外周helper T细胞的发育，该细胞在类风湿关节炎滑膜中富集
Ryosuke Tsurui,Hisakata Yamada,Takahiro Natori et al.
Ryosuke Tsurui et al.
Objective: Dysregulated T cell homeostasis has long been implicated in the pathogenesis of rheumatoid arthritis (RA), in the joint of which peripheral helper T (Tph) cells accumulate and form ectopic lymphoid organs. We e...
Integrated analysis of multi-omics data for the discovery of biomarkers and therapeutic targets for juvenile idiopathic arthritis [0.03%]
多组学数据综合分析发现儿童关节炎生物标志物和治疗靶点
Yi-Xin Cai,Xiao-Li Chen,Dai-Shan Zheng et al.
Yi-Xin Cai et al.
Background: Juvenile idiopathic arthritis (JIA) is a prevalent chronic rheumatic disease affecting children. Current medications merely alleviate symptoms rather than curing the disease. Hence, the identification and deve...
Association of COVID-19 with thyroid dysfunction and autoimmune thyroid disease: A retrospective cohort study [0.03%]
COVID-19与甲状腺功能异常和自身免疫性甲状腺疾病的相关性：一项回顾性队列研究
Jia Di,Xiaodong Ma,Tao Wu et al.
Jia Di et al.
Background: Since the end of the COVID-19 pandemic, the potential roles of thyroid-inflammatory derangements in driving or being associated with the prognosis of COVID-19 remain controversial. We aimed to clarify the asso...
Extrafollicular CD19lowCXCR5-CD11c- double negative 3 (DN3) B cells are significantly associated with disease activity in females with systemic lupus erythematosus [0.03%]
系统性红斑狼疮女性患者外周血中额外生发中心起源的CD19low CXCR5- CD11c-双阴性III型B细胞与疾病活动度密切相关
Carlo Chizzolini,Jean-Charles Guery,Fanny Noulet et al.
Carlo Chizzolini et al.
Objective: B cells play a major role in the development and maintenance of systemic lupus erythematosus (SLE). Double negative (DN) B cells defined by the lack of surface expression of IgD and CD27 have attracted recent i...
Mitochondrial DNA copy number and the risk of autoimmune diseases: A Mendelian randomization study with meta-analysis [0.03%]
线粒体DNA拷贝数与自身免疫性疾病风险的相关性：基于孟德尔随机化研究的meta分析
Mingzhu Liu,Xiongquan Long,Shuangshuang Fu et al.
Mingzhu Liu et al.
Background: Mitochondrial DNA plays a crucial role in the pathophysiology of autoimmune diseases (ADs). However, the association between mitochondrial DNA copy number (mtDNA-CN) and ADs risk is controversial. In this stud...
Vascular injury derived apoptotic exosome-like vesicles trigger autoimmunity [0.03%]
血管损伤衍生的凋亡小体样囊泡触发自身免疫反应
Sandrine Juillard,Annie Karakeussian-Rimbaud,Marie-Hélène Normand et al.
Sandrine Juillard et al.
According to a central tenet of classical immune theory, a healthy immune system must avoid self-reactive lymphocyte clones but we now know that B cells repertoire exhibit some level of autoreactivity. These autoreactive B cells are thought...
Unlocking therapeutic potential: Targeting lymphocyte activation Gene-3 (LAG-3) with fibrinogen-like protein 1 (FGL1) in systemic lupus erythematosus [0.03%]
解锁治疗潜力：通过纤维蛋白原样蛋白质1靶向淋巴细胞活化基因-3在系统性红斑狼疮中的作用
Bing Wang,Biqing Zhang,Min Wu et al.
Bing Wang et al.
Systemic lupus erythematosus (SLE) represents an autoimmune disorder that affects multiple systems. In the treatment of this condition, the focus primarily revolves around inflammation suppression and immunosuppression. Consequently, target...
Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary Sjögren's syndrome [0.03%]
单细胞转录组分析揭示了一线性舍格伦综合征唇腺微环境的异质性
Jun Huang,Jia Tang,Chen Zhang et al.
Jun Huang et al.
Objective: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder with an unclear pathogenetic mechanism in the labial gland. This study aims to investigate the cellular and molecular mechanisms contributing ...