Across ancestries, HLA-B∗08:01∼DRB1∗03:01 (DR3) and HLA-DQA∗01:02 (DR2) increase the risk to develop juvenile-onset systemic lupus erythematosus through low complement C4 levels [0.03%]
跨种族，人类白细胞抗原-B*08：01～DRB1*03：01（DR3）和人类白细胞抗原-DQA*01：02（DR2）通过低补体C4水平增加儿童期系统性红斑狼疮的发病风险
Yves Renaudineau,Amandine Charras,Valentina Natoli et al.
Yves Renaudineau et al.
Objective: Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease with a strong genetic component. Genetic burden is higher in children when compared to patients with adult-onset SLE, contributin...
Michaela Fehringer,Thomas Vogl
Michaela Fehringer
Autoimmune rheumatic diseases (ARDs) are a heterogeneous group of conditions characterized by excessive and misdirected immune responses against the body's own musculoskeletal tissues. Their exact aetiology remains unclear, with genetic, de...
Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation [0.03%]
炎症期间免疫细胞迁移时脱落的大分子可溶性CD18复合物具有独特的ICAM-1结合特性
Alexey Ferapontov,Anders Mellemkjær,Helen M McGettrick et al.
Alexey Ferapontov et al.
The family of heterodimeric CD11/CD18 integrins facilitate leukocyte adhesion and migration in a wide range of normal physiologic responses, as well as in the pathology of inflammatory diseases. Soluble CD18 (sCD18) is found mainly in compl...
Aliakbar Givian,Amin Azizan,Ahmadreza Jamshidi et al.
Aliakbar Givian et al.
Iron is a crucial element for living organism in terms of oxygen transport, hematopoiesis, enzymatic activity, mitochondrial respiratory chain function and also immune system function. The human being has evolved a mechanism to regulate bod...
The role of UV-induced cutaneous matrix metalloproteinases and mi-RNAs in the pathogenesis of lupus erythematosus [0.03%]
紫外线诱导的皮肤基质金属蛋白酶和微小RNA在狼疮发病机制中的作用
I Ivanova,T Svilenska,T Maisch et al.
I Ivanova et al.
Cutaneous (CLE) and systemic lupus erythematosus (SLE) are autoimmune diseases with a multifactorial pathogenesis. Ultraviolet radiation (UVR) is the most important trigger of CLE; however, the degree of photosensitivity varies between the ...
IL-12 family cytokines and autoimmune diseases: A potential therapeutic target? [0.03%]
白细胞介素-12族细胞因子与自身免疫病：潜在的治疗靶点？
Xiaoyu Cui,Wu Liu,Hanxue Jiang et al.
Xiaoyu Cui et al.
In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases. In autoimmune diseases, IL-12 family cytok...
Dissecting the genetic basis and mechanisms underlying the associations between multiple extrahepatic factors and autoimmune liver diseases [0.03%]
剖析自身免疫性肝病与多种体外因素相关联的遗传基础和机制
Zheng Zhang,Jiayi Zhang,Xinyang Yan et al.
Zheng Zhang et al.
Background: Autoimmune liver diseases (AILDs) encompass autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC). The onset of these diseases is fundamentally influenced by g...
Development of a standardized monoclonal antibody to the inner lipoyl domain of PDC-E2 as a potential international AMA reference [0.03%]
用于自身免疫性肝炎检测的抗PDC-E2抗体国际标准品的研制及其性能评估
Zhuye Qin,Fangming Cheng,Mingming Zhang et al.
Zhuye Qin et al.
The detection of antimitochondrial antibodies (AMA) is the specific diagnostic marker for primary biliary cholangitis. Indeed, it is the most specific autoantibody in clinical autoimmunity, with a high titer directed response to the inner l...
Prognostic value of β1 adrenergic receptor autoantibodies for microvascular obstruction in patients with STEMI with Post-PCI: A prospective cohort study [0.03%]
β1肾上腺素能受体自身抗体对STEMI患者经皮冠状动脉介入术后微血管阻塞的预后价值：前瞻性队列研究
Ning Cao,Wenxi Dang,Yanguo Xin et al.
Ning Cao et al.
Backgrounds: Coronary microvascular obstruction (MVO) frequently occurs in patients with ST-segment elevation myocardial infarction (STEMI) following percutaneous coronary intervention (PCI), leading to poor prognosis. β...
The interplay between epidermal barrier distribution, microbiota composition, and immune infiltrate defines and stratifies psoriasis patients and is associated with disease severity [0.03%]
表皮屏障分布、微生物群组成和免疫浸润的相互作用定义并划分了银屑病患者并与疾病严重程度相关
Elizabeth M Ortega Rocha,Paul Hernández-Herrera,Sofia V de Los Santos-Carmona et al.
Elizabeth M Ortega Rocha et al.
Psoriasis is a chronic inflammatory autoimmune skin disease characterized by keratinocyte hyperproliferation, primarily driven by the IL-23/IL-17 axis. In addition to immune response, various skin components, including the epidermal barrier...