A comparative study of different assays for autoantibodies detection in patients with autoimmune gastritis [0.03%]
自身免疫性胃炎患者自身抗体检测方法的比较研究
Małgorzata Osmola,Caroline Hémont,Marcin Romańczyk et al.
Małgorzata Osmola et al.
Objective: Autoimmune gastritis (AIG) is an important health problem and a risk factor for gastric neoplasms. This study assessed the diagnostic performance of different assays for anti-parietal cell antibodies (APCA) and...
Characteristics of polyclonal anti-interferon-gamma autoantibodies and novel diagnostic strategies: A prospective cohort study of new biomarkers [0.03%]
多克隆抗干扰素-γ自身抗体的特征及新的诊断策略：新生物标志物前瞻性队列研究
Xidong Wang,Feng Ye,Hongling Liu et al.
Xidong Wang et al.
Background: Anti-γ interferon autoantibody (AIGA) syndrome is a widespread and grossly underestimated immunodeficiency disorder characterized by high mortality rates and a lack of standardized diagnostic methods. A highl...
Carl Turesson,Johan Rönnelid,Alf Kastbom
Carl Turesson
Background and purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressively destructive polyarthritis. Key autoimmune features include the presence of autoantibodies. The purpose of...
Quentin Simon,François Gaillard,John Tchen et al.
Quentin Simon et al.
Systemic lupus erythematosus (SLE) activity decreases in some patients with end-stage kidney disease (ESKD). The impact of ESKD on the immune cell profile of SLE patients and lupus activity remains unclear. In this study, we aimed at charac...
The changes in global burden of autoimmune diseases two years after the COVID-19 pandemic: a trend analysis based on the Global Burden of Disease Study 2021 [0.03%]
基于全球疾病负担研究2021的新冠肺炎疫情后两年自身免疫性疾病疾病负担变化趋势分析
Danting Zhang,Wanyu Hua,Fangfang Sun et al.
Danting Zhang et al.
Background: Data on the epidemiological changes in the global burden of autoimmune diseases (ADs) after the Coronavirus disease 2019 (COVID-19) pandemic is lacking. This study investigated the impact of the COVID-19 pande...
A placebo-controlled Phase 2 trial of E6011, anti-human fractalkine monoclonal antibody, in primary biliary cholangitis [0.03%]
E6011（抗人 fractalkine 单克隆抗体）治疗原发性胆汁性肝硬化II期安慰剂对照临床试验
Atsushi Tanaka,Masanori Abe,Tadashi Namisaki et al.
Atsushi Tanaka et al.
Background: While ursodeoxycholic acid (UDCA) remains the first-line therapy for primary biliary cholangitis (PBC), the autoimmune nature of PBC underscores the need for treatments targeting immunological pathways that ma...
Leucine enhances the cGAS-STING-NLRP3 pathway in autoimmune thyroiditis [0.03%]
亮氨酸通过增强cGAS-STING-NLRP3通路促进自身免疫性甲状腺炎
Xin Shen,Tingting Feng,Shangbin Li et al.
Xin Shen et al.
Background: Branched-chain amino acids (BCAAs), including isoleucine (Ile), leucine (Leu), and valine (Val), are substrates for synthesising nitrogenous compounds and signalling molecules involved in regulating immunity. ...
Unveiling the crucial role of CD8+ T cell and endothelial cell interaction in rheumatoid arthritis through the integrated analysis of spatial transcriptomics and bulk/single-cell RNA-seq [0.03%]
通过空间转录组学和批量/单细胞RNA测序的综合分析揭示CD8+T细胞和内皮细胞在类风湿性关节炎中相互作用的关键作用
Yu Lai,Zishao Zhong,Runze Li et al.
Yu Lai et al.
Background: Rheumatoid arthritis (RA) is a prevalent chronic autoimmune disease. While the chemokine signaling pathway plays a pivotal role in RA pathogenesis, the specific cellular interactions remain unclear. ...
Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes [0.03%]
横跨组织转录组关联研究揭示了新型银屑病易感基因
Fei Yan,Jing Tao,Jie Liu et al.
Fei Yan et al.
Background: Psoriasis is a chronic, immune-mediated inflammatory skin disorder with a strong genetic component. Although numerous GWAS have identified risk loci, many associated variants lie in non-coding regions, complic...
Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases [0.03%]
空气中的罪魁祸首：PM、二氧化硅和TCDD在自身免疫疾病中的综述性研究
Daniel Galeano-Sánchez,Victoria Morales-González,Diana M Monsalve et al.
Daniel Galeano-Sánchez et al.
Autoimmune diseases (ADs) are immunological disorders arising from the breakdown of immune tolerance, influenced by various internal and external factors. Persistent exposure to environmental factors, particularly air pollution, is linked t...