Xianzhi Zhang,Rui Huang,Sanjana Gopalakrishnan et al.
Xianzhi Zhang et al.
Bioorthogonal nanocatalysts in the form of 'nanozymes', are promising tools for generating imaging and therapeutic molecules in living systems. These systems use transformations developed by synthetic chemists to effect transformations that...
Developments in Photoredox-Mediated Alkylation for DNA-Encoded Libraries [0.03%]
光氧化还原介导的DNA编码库烷基化的发展
Shivani Patel,Shorouk O Badir,Gary A Molander
Shivani Patel
Recently, DNA-encoded library (DEL) technology has emerged as an innovative screening modality for the rapid discovery of therapeutic candidates in pharmaceutical settings. This platform enables a cost-effective, time-efficient, and large-s...
Sophie L Shevick,Meghan A Baker,Ryan A Shenvi
Sophie L Shevick
Cobalt/nickel dual-catalysis enables the branch-selective hydroarylation of olefins through a novel "cage-rebound" transmetalation pathway. This process allows for the rapid introduction of complexity by coupling readily available iodoarene...
Gen Li,Colet Te Grotenhuis,Alexander T Radosevich
Gen Li
Hillary J Dequina,Jennifer M Schomaker
Hillary J Dequina
Harnessing the chemistry of onium ylide intermediates generated from transition metal catalysis is a powerful strategy to convert simple precursors into complex scaffolds. While the chemistry of onium ylides has been studied for over three ...
Jochen Spiegel,Santosh Adhikari,Shankar Balasubramanian
Jochen Spiegel
Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity, but recent evidence suggests their involvement in key genome functi...
Jun-Bin Li,Hong-Wen Liu,Ting Fu et al.
Jun-Bin Li et al.
Small-molecule near-IR (NIR) optical imaging has experienced tremendous advancements over the past two decades, playing important roles in both theory and application in the biomedical field. NIR optical imaging affords improved contrast an...
Lucas J Oxtoby,John A Gurak Jr,Steven R Wisniewski et al.
Lucas J Oxtoby et al.
The Mizoroki-Heck reaction is one of the most studied palladium-catalyzed cross-coupling reactions, representing a powerful method for forming C-C bonds between diverse substrates with broad functional group compatibility. However, the redu...
Paul S Riehl,Corinna S Schindler
Paul S Riehl
Catalytic carbonyl-olefin metathesis reactions enable direct carbon-carbon bond formation between carbonyl and olefin substrates relying on carbonyl-activation with a suitable Lewis acid. Based on this reaction design principle, efficient p...
Gary A Huber,J Andrew McCammon
Gary A Huber
Brownian dynamics (BD) is a technique for carrying out computer simulations of physical systems that are driven by thermal fluctuations. Biological systems at the macromolecular and cellular level, while falling in the gap between well-esta...