Quantifying risk modifiers of hereditary hemochromatosis using genomic and electronic health record data [0.03%]
利用基因组和电子健康记录数据量化遗传性血色素沉着病的风险修饰因素
Jarkko Toivonen,Jonna Clancy;FinnGen;Fredrik Åberg,Jarmo Ritari et al.
Jarkko Toivonen et al.
Background & aims: Hereditary hemochromatosis is an autosomal recessive disorder of excessive iron accumulation. Early diagnosis enables treatment before organ damage. The C282Y variant in the HFE gene is the main cause, ...
Real-world quality of life and healthcare resource utilization in patients with metabolic dysfunction-associated steatohepatitis [0.03%]
与代谢功能障碍相关性肝炎患者的生活质量及医疗资源利用状况
Jens Marquardt,Riku Ota,Giada Sebastiani et al.
Jens Marquardt et al.
Background & aims: Metabolic dysfunction-associated steatohepatitis (MASH) is complicated by fibrosis and comorbid conditions. We investigated the real-world burden of fibrosis and additional cardiovascular renal and meta...
Platelet hyperactivation drives oxidized mitochondrial DNA-induced neutrophil extracellular traps formation in biliary atresia [0.03%]
血小板活化驱动胆道闭锁中氧化型线粒体DNA诱导的中性粒细胞胞外陷阱形成
Ledong Tan,Sige Ma,Rongchen Ye et al.
Ledong Tan et al.
Background and aims: Biliary atresia (BA) is a progressive neonatal cholangiopathy characterized by unresolved inflammation and neutrophil extracellular traps (NET) formation. Although neutrophils contribute to bile duct ...
Atezolizumab-Bevacizumab in Very Elderly With Hepatocellular Carcinoma: Age Alone Is Not a Limiting Factor Except in ALBI Grade 3 [0.03%]
阿特朱单抗-贝伐珠单抗治疗非常老年的肝细胞癌患者：除ALBI分级为3级的情况外，年龄本身不是限制因素
Chloé Métivier,Claudia Campani,Manon Allaire et al.
Chloé Métivier et al.
Background and aims: Evidence on atezolizumab plus bevacizumab (AtezoBev) in very elderly with hepatocellular carcinoma (HCC) remains rare in European ancestry population. We compared outcomes in patients aged ≥75 years ...
EXTERNAL VALIDATION OF A SIMPLE RISK STRATIFICATION FOR PORTAL HYPERTENSION-RELATED CLINICAL DETERIORATION IN PATIENTS WITH ASCITES [0.03%]
肝硬化腹水患者门脉高压相关临床恶化的简易风险分层的外部验证研究
Stefania Gioia,Manuela Merli,Simone Di Cola et al.
Stefania Gioia et al.
Phase II trial with nivolumab and sorafenib in HCC identified enrichment of immunosuppressive monocytes in patients with Child-Pugh B liver dysfunction [0.03%]
一项尼伏单抗与索拉非尼联合治疗肝癌的II期试验确定了Child-Pugh B级肝功能不全患者的免疫抑制型单核细胞增多现象
Bridget P Keenan,Zenghua Fan,Bryan Khuong Le et al.
Bridget P Keenan et al.
Background and aims: Immune checkpoint inhibition (ICI) and anti-angiogenic therapies are active in hepatocellular carcinoma (HCC), although patients with impaired hepatic function have worse outcomes. ...
Evaluation of novel assays of non-ceruloplasmin copper to monitor chelation treatment in patients with Wilson disease: Monitoring chelation treatment in Wilson disease [0.03%]
评估威尔森病患者螯合治疗中新铜测定方法的效果：监测威尔森病的螯合疗法
Peter Ott,Thomas Sandahl,Aftab Ala et al.
Peter Ott et al.
Background: We examined the use of two newer measures of non-ceruloplasmin bound copper (NCC) and 24-hour urinary Cu excretion (UCE) to monitor chelation therapy in clinically stable Wilson Disease (WD). ...
Very Low Energy Ketogenic Diet vs Mediterranean Diet for MASLD: Superior Steatosis Reduction in a Randomised Pilot Study [0.03%]
与地中海饮食相比，低碳生酮饮食能更有效地改善非酒精性脂肪性肝炎患者肝脏脂肪变性的随机对照试点研究
Ann M Farrell,Tonya Paris,Evelyn B Parr et al.
Ann M Farrell et al.
Background & aims: Weight loss is the cornerstone of treatment for metabolic dysfunction associated steatotic liver disease (MASLD). This pilot study compared the efficacy and safety of a very low energy ketogenic diet (V...
PERSoN4: A Multiparametric Ultrasound Model to Improve CEUS LI-RADS for HCC [0.03%]
PERSoN4：一种多参数超声模型，可改善HCC的CEUS LI-RADS
Esposto Giorgio,Santini Paolo,Galasso Linda et al.
Esposto Giorgio et al.
Background and aim: Dynamic Contrast-Enhanced Ultrasound (D-CEUS) could be a valuable tool in the non-invasive diagnosis of HCC with atypical vascular imaging features. ...
The qEEG-TIPS score: Development of a predictive model for recurrent overt hepatic encephalopathy after elective TIPS [0.03%]
qEEG-TIPS评分：预测经颈静脉肝内门体分流术后再发显性肝性脑病的模型构建
Dario Saltini,Lisa Zarantonello,Alberto Zanetto et al.
Dario Saltini et al.
Background & aims: Overt hepatic encephalopathy (OHE) continues to be the primary complication following transjugular intrahepatic portosystemic shunt (TIPS) placement. It significantly impairs patients' health-related qu...