Ezequiel Mauro,Tiago de Castro,Marcus Zeitlhoefler et al.
Ezequiel Mauro et al.
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide and primarily affects individuals with cirrhosis. While viral hepatitis has historically been the predominant cause, the burden of HCC is increa...
Hepatocyte iron suppresses liver fibrosis via fibrolytic neutrophil recruitment in cholestasis [0.03%]
肝细胞铁通过募集纤溶中性粒细胞抑制胆汁淤积性肝纤维化
Yohei Kanamori,Akihiro Nita,Keiichi I Nakayama et al.
Yohei Kanamori et al.
Background & aims: Although it is well documented that iron promotes hepatocyte death in chronic liver disease, recent studies have suggested that iron in hepatocytes also has a protective role against such disease. Howev...
Pre-emptive TIPS with 8-mm stents reduces hepatic encephalopathy without compromising efficacy in acute variceal bleeding [0.03%]
预防性使用8毫米直径的TIPS可以减少急性静脉曲张出血患者的肝性脑病而不降低其疗效
Yong Lv,Junjun Ye,Wei Bai et al.
Yong Lv et al.
Background & aims: Pre-emptive transjugular intrahepatic portosystemic shunt (TIPS) improves outcomes in high-risk acute variceal bleeding but its use is limited by hepatic encephalopathy (HE). While stent diameter and po...
Overt hepatic encephalopathy after elective and preemptive TIPS: Risk factors and prognosis [0.03%]
经选择性和预防性经颈静脉肝内门体分流术后的显性肝性脑病：危险因素及预后
Marika Rudler,Charlotte Bouzbib,Philippe Sultanik et al.
Marika Rudler et al.
Background & aims: Overt hepatic encephalopathy (OHE) develops in 30-50% of patients after transjugular intrahepatic portosystemic shunt (TIPS) placement, depending on patient characteristics and TIPS indication. Data on ...
Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis [0.03%]
解剖学切除与肝癌早期复发降低有关：一种机器学习分析方法
Xiang-Pan Meng,Fang-Ming Chen,Tian-Yu Tang et al.
Xiang-Pan Meng et al.
Background & aims: Anatomical resection (AR) for hepatocellular carcinoma (HCC) could improve micrometastasis eradication and reduce their recurrence, but conflicting findings suggest heterogeneous treatment effects (HTEs...
Artificial intelligence as a ploy to delve into the intricate link between genetics and mitochondria in patients with MASLD [0.03%]
人工智能在探究遗传和线粒体在MASLD患者中的复杂联系方面的作用研究
Miriam Longo,Erika Paolini,Marica Meroni et al.
Miriam Longo et al.
Background & aims: Mitochondrial (mt-) D-loop and cell-free circulating (ccf-) mtDNA fragments, respectively reflecting mt-mass and tissue damage, are promising metabolic dysfunction-associated steatotic liver disease (MA...
Prognostic value of radiological and pathological complete response following immune-based conversion therapy in patients with unresectable hepatocellular carcinoma (GUIDANCE004) [0.03%]
基于免疫的转化治疗后不可切除肝细胞癌患者影像学和病理学完全缓解的预后价值(GUIDANCE004)
Da-Long Yang,Yi-He Yan,Yong-Cheng Lai et al.
Da-Long Yang et al.
Background & aims: It is unclear whether radiological complete response (rCR) and pathological complete response (pCR) after immune-based conversion therapy are associated with each other and with the prognosis of patient...
Rectus femoris ultrasound identifies sarcopenia and predicts poor outcomes in patients with acute decompensation of cirrhosis [0.03%]
股直肌超声识别肝硬化的肌肉减少症并预测急性失代偿患者的不良预后
Roberta Gagliardi,Paola Campadello,Silvia Brocco et al.
Roberta Gagliardi et al.
Background & aims: Sarcopenia is common and associated with poor outcomes in decompensated cirrhosis. While computed tomography (CT) scan, with measurement of skeletal muscle index (SMI) at L3, is the gold standard for as...
Persistent risk of hepatocellular carcinoma despite improvement of liver stiffness in patients with chronic HBV with advanced fibrosis [0.03%]
尽管慢性HBV患者晚期纤维化有所改善，但肝细胞癌的持续风险仍然存在
Lesley A Patmore,Lilian Y Liang,George Papatheodoridis et al.
Lesley A Patmore et al.
Background & aims: Patients with chronic HBV (CHB) with advanced fibrosis are at high risk for hepatocellular carcinoma (HCC). Liver stiffness measurement (LSM) correlates with fibrosis in untreated patients, and is used ...
Intratumoral microbial heterogeneity in HCC reveals a potential therapeutic target [0.03%]
肝癌内的肿瘤内微生物异质性揭示了潜在的治疗靶点
Liqiu Li,Mingxuan Wang,Zhaodi Jiang et al.
Liqiu Li et al.
Background & aims: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality worldwide, and its therapeutic challenges are largely influenced by the complexity of the tumor microenvironment (T...