FKBP9 enhances IGF2BP1-mediated m6A recognition to promote hepatocellular carcinoma progression [0.03%]
FKBP9通过增强IGF2BP1介导的m6A识别促进肝细胞癌进展
Facai Yang,Anfeng Si,Cheng Chi et al.
Facai Yang et al.
Background & aims: N6-methyladenosine (m6A) modification regulates mRNA stability and translation to promote cancer progression. FK506-binding protein 9 (FKBP9), a peptidyl-prolyl isomerase, is associated with carcinogene...
Alcohol-related hepatitis induces a specific fibrosis profile through YAP activation in myofibroblasts [0.03%]
酒精相关性肝炎通过肌纤维母细胞中的YAP活化诱导特异的纤维化特征
Line Carolle Ntandja Wandji,Mohamed Bou Saleh,Cyril Sobolewski et al.
Line Carolle Ntandja Wandji et al.
Background & aims: Yes-associated protein (YAP) impairs hepatocyte regeneration in alcohol-related hepatitis (AH), but its impact on fibrogenesis remains to be characterized. Our aim here was to describe fibrogenesis and ...
Disparities in transplant access and outcomes after first cirrhosis decompensation in alcohol-related liver disease [0.03%]
酒精性肝病患者首次失代偿后移植准入和预后的差异性分析
José Ursic Bedoya,Charlotte De Choudens,Margaux Delhomme et al.
José Ursic Bedoya et al.
Background & aims: Several studies have shown that non-medical factors can determine access to liver transplantation (LT). Most of these studies are from North America, where the healthcare system has specific features th...
An engineered human hepatitis A virus capable of rapid proliferation in vitro and causing hepatitis in mice [0.03%]
一种能够在体外快速增殖并感染小鼠引发肝炎的人类甲型肝炎病毒工程变异株
Jian Li,Pei-Yu Jiang,Xiu-Li Yan et al.
Jian Li et al.
Background & aims: Hepatitis A virus (HAV) remains a significant public health threat. The HM175-mp4-based mouse model has advanced pathogenesis research, but its slow in vitro replication limits reverse genetic studies. ...
Blood and tissue dysregulated bile acids and short-chain fatty acids in cholangiocarcinoma [0.03%]
胆管癌中血液和组织中失调的胆汁酸和短链脂肪酸
Yaming Liu,Hind Hassan,Tayla R Brooks et al.
Yaming Liu et al.
Background & aims: Dysregulated bile acid (BA) homeostasis has been implicated in the initiation and progression of cholangiocarcinoma (CCA). The aim of this study was to investigate the roles of circulating and tumor BAs...
Non-canonical splice variant of PFKFB4 in hepatocellular carcinoma activates AKT through direct interaction [0.03%]
肝癌中的非经典PFKFB4剪接变体通过直接相互作用激活AKT
Ho-Lee Wan,Wenjie Luo,Ho Ting Henry Chan et al.
Ho-Lee Wan et al.
Background & aims: The glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 (PFKFB4) has emerged as a vital oncogene in many cancer types as a result of its metabolic function and signaling pathways. Ho...
Immunologic effects of locoregional therapies for unresectable hepatocellular carcinoma [0.03%]
不可切除肝细胞癌局部区域性治疗的免疫效应
Robin Schmidt,Bernhard Gebauer,Nilufar Akbari et al.
Robin Schmidt et al.
Background & aims: The combination of locoregional therapies (LRT) with immune checkpoint inhibitors (ICIs) in unresectable hepatocellular carcinoma (HCC) is expected to enhance immune-mediated anti-tumor effects. Althoug...
Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury [0.03%]
Nogo-B通过损害单核细胞来源的巨噬细胞的摄取功能加重脓毒症肝损伤
Weizhe Zhong,Jian Xu,Fei Li et al.
Weizhe Zhong et al.
Background & aims: Efferocytosis is essential for maintaining tissue homeostasis and resolving inflammation, but this process is compromised during sepsis. This study aimed to elucidate the role of neurite outgrowth inhib...
Platelet protease nexin-1 limits fibrinolysis in patients with cirrhosis [0.03%]
血小板纤溶抑制因子蛋白酶抑制物-1限制肝硬化患者的纤溶作用
Alix Riescher-Tuczkiewicz,Stéphane Loyau,Laurence Venisse et al.
Alix Riescher-Tuczkiewicz et al.
Background & aims: The role of protease nexin 1 (PN-1), a serine protease inhibitor that regulates both coagulation and fibrinolysis, is unknown in patients with cirrhosis. This study aimed to provide a comprehensive asse...
TAF15 in tumor-associated macrophages enhances protumorigenic polarization and promotes cholangiocarcinoma progression [0.03%]
肿瘤相关巨噬细胞中的TAF15增强促肿瘤极化并促进胆管癌进展
Yu Liu,Bing Xu,Tianming Zhao et al.
Yu Liu et al.
Background & aims: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and aggressive cancer. Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), where they facilitate the maligna...