MVI-targeted carbon-ion radiotherapy combined with immunotherapy for advanced hepatocellular carcinoma: Phase Ib DEPARTURE trial [0.03%]
针对微血管侵犯的碳离子放疗联合免疫治疗用于晚期肝细胞癌患者的Ib期DEPARTURE试验
Sadahisa Ogasawara,Keisuke Koroki,Hirokazu Makishima et al.
Sadahisa Ogasawara et al.
Background & aims: Advanced hepatocellular carcinoma (HCC) with macrovascular invasion (MVI) carries an extremely poor prognosis, necessitating novel therapeutic strategies. This phase Ib trial evaluated the safety and pr...
Response-guided bulevirtide ± pegylated interferon alfa-2a: long-term outcomes observed in the nationwide Austrian hepatitis D cohort study [0.03%]
基于应答的布雷维定±聚乙二醇干扰素治疗：奥地利全国性乙肝D病毒感染队列研究中的长期结局观察
Michael Schwarz,Marlene Hintersteininger,Caroline Schwarz et al.
Michael Schwarz et al.
Background & aims: Chronic hepatitis D (CHD) often progresses to advanced chronic liver disease (ACLD). Bulevirtide (BLV) is approved for CHD, yet treatment duration, management of suboptimal response, and the potential f...
Net benefit of surveillance varies by hepatocellular carcinoma risk in patients with cirrhosis [0.03%]
肝硬化患者中根据肝细胞癌风险不同监测的净效益不同
Akash Patel,Elena Gavrila,Sruthi Yekkaluri et al.
Akash Patel et al.
Background: The risk of hepatocellular carcinoma (HCC) and net benefit of surveillance may differ between patients with cirrhosis. We compared the benefits and harms of HCC surveillance across risk strata in patients with...
AI-Guided Additive Scoring Model for Differential Diagnosis of Primary Liver Cancer [0.03%]
基于人工智能的加权评分模型在原发性肝癌鉴别诊断中的应用研究
Rebekka J S Salzmann,Tudor Mocan,Arnulf G Willms et al.
Rebekka J S Salzmann et al.
Background & aims: Within the Liver Imaging Reporting and Data System (LI-RADS), LI-RADS Malignant (LR-M) lesions remain diagnostically challenging: imaging indicates malignancy but often fails to distinguish hepatocellul...
Deep Learning-Based Generation of Synthetic Multiphasic MRI In Hepatocellular Carcinoma and Cirrhosis [0.03%]
基于深度学习的合成多相磁共振成像在肝细胞癌和肝硬化中的生成
Sara A Abosabie,Salma A S Abosabie,Weicheng Dai et al.
Sara A Abosabie et al.
Background and aims: There is a growing interest in reducing contrast medium use and the lengthy scan duration in liver imaging. This proof-of-concept study aimed to evaluate the feasibility of deep learning-based generat...
Advanced: post-hoc analysis of the ABC-01, -02 and -03 clinical trials [0.03%]
后续分析：ABC-01、02和03临床试验
Angela Lamarca,Paul Ross,Harpreet S Wasan et al.
Angela Lamarca et al.
Introduction: Prior data suggest that patients with intrahepatic cholangiocarcinoma (iCCA) have a better prognosis compared to other biliary tract cancers (BTC). However, granularity on outcomes for advanced extrahepatic ...
Elevation of Liver Elastic Value Following Radiofrequency Ablation Reflected Neutrophils Mediated Abscopal Effect in Liver Cancer [0.03%]
射频消融后肝纤维化弹性值升高反映了中性粒细胞介导的远隔效应
Ke Lin,Jiayao Huang,Nan Zhang et al.
Ke Lin et al.
Background & aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally. Radiofrequency ablation (RFA) is a widely used treatment for HCC, but its efficacy is often limited by tumor relap...
Platelets accelerate endoplasmic reticulum stress and promote hepatic steatosis [0.03%]
血小板通过加速内质网应激促进肝脂肪变性
Martina Derler,Twisha Dube,Elisabeth Ableitner et al.
Martina Derler et al.
Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, characterized by endoplasmic reticulum (ER) stress, which impairs hepatic lipoprotein metabolis...
Irreversible Electroporation versus Stereotactic Body Radiotherapy for Solitary Hepatocellular Carcinoma ≤ 5 cm: A Multicenter Retrospective Study [0.03%]
不可逆电穿孔与立体定向体放射治疗对于≤5cm的单发肝细胞癌的效果：一项多中心回顾性研究
Min Xu,Jinhua Pan,Senxiang Yan et al.
Min Xu et al.
Background & aims: Irreversible electroporation (IRE) and stereotactic body radiotherapy (SBRT) are important therapeutic alternatives for hepatocellular carcinoma (HCC) unsuitable for thermal ablation, but comparative ou...
Dental prophylactic Interventions are Associated with Lower Decompensation-related Hospitalizations over 2 years in Cirrhosis [0.03%]
dental prophylactic干预与肝硬化患者2年内去补偿相关住院减少有关
Jasmohan S Bajaj,Scott Silvey,Anas Aljabi et al.
Jasmohan S Bajaj et al.
Background: Poor oral health is associated with systemic inflammation and unfavorable outcomes in chronic diseases, including cirrhosis. Data on whether regular dental prophylaxis and periodontal maintenance services(DPS)...