Validation of a data-driven clustering model for MASLD: Evidence from three large-scale Asian cohorts [0.03%]
基于数据的MASLD聚类模型的验证：三项大规模亚洲队列研究证据
Xiao-Dong Zhou,Sherlot Juan Song,Chloe Yitian Guo et al.
Xiao-Dong Zhou et al.
Background & aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a heterogeneous condition that presents varying risks for liver-related and cardiovascular complications. Clustering methods have iden...
Epidemiology, clinical, molecular features, and prognosis of early-onset biliary tract cancer: A systematic review and meta-analysis [0.03%]
早发性胆道癌的流行病学、临床、分子特征及预后：系统评价和 Meta 分析
Erman Akkus,Antonella Cammarota,Laura Izquierdo-Sanchez et al.
Erman Akkus et al.
Background & aims: Early-onset gastrointestinal cancers represent a growing global health concern. Among these, early-onset biliary tract cancer (EO-BTC) remains relatively understudied. In this systematic review, we synt...
Liver fibrosis is associated with clinical and economic burden of cardiovascular disease in MASH [0.03%]
肝脏纤维化与MASH中心血管疾病临床和经济负担有关
Kathleen Corey,Anurag Mehta,Kamal Kant Mangla et al.
Kathleen Corey et al.
Background & aims: The clinical and economic burden of cardiovascular (CV) disease (CVD) in patients with metabolic dysfunction-associated steatohepatitis (MASH) is incompletely understood. The unCoVer-MASH cohort study a...
HBV X protein regulates cancer stemness and tumor invasiveness through SENP1 in hepatocellular carcinoma [0.03%]
乙型肝炎病毒X蛋白通过SENP1调节肝癌干细胞特性及肿瘤侵袭性
Yu-Chih Wu,Yen-Chiao Huang,Yung-Che Kuo et al.
Yu-Chih Wu et al.
Background & aims: The niche in hepatocellular carcinoma (HCC) critically influences cancer stem cell (CSC)-associated properties, including stemness, early recurrence, and poor prognoses. HBV infection acts as a niche dr...
L actococcus A phages predict ACLF while Enterococcus B phages predict bacterial infection in decompensated cirrhosis [0.03%]
肠杆菌噬菌体预测细菌感染，而 Lancefield群噬菌体预测ACLF在肝硬化失代偿期中的作用
Lore Van Espen,Maximilian Joseph Brol,Lila Close et al.
Lore Van Espen et al.
Background & aims: As portal hypertension progresses in cirrhosis, bacterial translocation across a compromised gut barrier leads to endotoxemia, systemic inflammation and immune dysfunction. Gut phages play a key role in...
Enhanced nuclear localization of small heterodimer partner in metabolic dysfunction-associated steatohepatitis [0.03%]
小异二聚体伴侣蛋白增強的核定位与代谢功能障碍相关性脂肪肝炎的关系研究
Shih-Chieh Chien,Chiung-Yu Chen,Hung-Wen Tsai et al.
Shih-Chieh Chien et al.
Background & aims: The nuclear factor small heterodimer partner (SHP) plays a dual function in maintaining bile acid (BA) homeostasis and exerting anti-inflammatory effects. While SHP might be associated with metabolic dy...
MELD 3. i and the case for continuous updating in liver allocation [0.03%]
MELD 3. 0在肝脏分配中的应用及持续更新的必要性
Ian A Rowe,Juan G Abraldes
Ian A Rowe
Binge drinking acutely induces hepatic steatosis which is readily reversible: A real-world observational study in healthy adults [0.03%]
一次性的酗酒可诱导健康成年人的肝脏脂质蓄积且该现象是可逆的：一项真实世界中的观察性研究
Kristoffer Kjærgaard,Jeppe Mygind Yeoman,Peter Lykke Eriksen et al.
Kristoffer Kjærgaard et al.
Background & aims: Binge drinking is a common pattern of alcohol intake often considered particularly harmful. However, its immediate effects on the development of hepatic steatosis and early alcohol-related liver injury ...
Viral sequence analysis of chronic hepatitis B patients treated with the siRNA JNJ-73763989 in phase II clinical trials [0.03%]
siRNA(JNJ-73763989)治疗慢性乙型肝炎患者Ⅱ期临床试验的病毒学序贯分析
Thierry Verbinnen,Erkki Lathouwers,John Jezorwski et al.
Thierry Verbinnen et al.
Background & aims: JNJ-73763989 (JNJ-3989) is a small-interfering RNA composed of two triggers targeting the HBsAg and HBx protein open reading frame, designed to target all HBV RNAs for degradation. JNJ-3989 + nucleos(t)...