Geography-independent mucosal microbiota alterations in primary sclerosing cholangitis persist after liver transplantation [0.03%]
原发性硬化性胆管炎的地理独立性的黏膜微生物群改变在肝移植后持续存在
Lukas Bajer,Petra Polakovicova,Marie Heczkova et al.
Lukas Bajer et al.
Background & aims: Primary sclerosing cholangitis (PSC)-associated alterations of fecal gut microbiota have already been described, but data on the mucosal microbiota are still limited. We aimed to further define disease-...
A liver gene signature links liver cancer risk in chronic viral hepatitis to intrahepatic IgA plasma cells [0.03%]
一种肝脏基因特征标记将慢性病毒性肝炎的肝癌风险与肝脏内的IgA浆细胞联系起来
Nicolaas Van Renne,Fleur Ballet,Stijn Van Hees et al.
Nicolaas Van Renne et al.
Background & aims: Chronic viral hepatitis remains a leading cause of liver cancer-related mortality worldwide. We aimed to identify genetic markers associated with hepatocellular carcinoma (HCC) risk in precancerous live...
Comparative evaluation of regression and machine-learning models for hepatocellular carcinoma risk stratification across diverse aetiologies [0.03%]
比较评估回归和机器学习模型在不同病因肝细胞癌风险分层中的应用效果
Pierre Nahon,Richard Layese,Pierre-André Natella et al.
Pierre Nahon et al.
Background & aims: We aimed to develop machine learning (ML) models for hepatocellular carcinoma (HCC) risk stratification in patients with cirrhosis and to test their ability to identify those with an annual HCC incidenc...
Genetic and lifestyle modifiers of haemochromatosis-related clinical outcomes in HFE C282Y homozygotes [0.03%]
HFE C282Y同合子中遗传和生活方式的肝硬化临床结局修饰因素
Mitchell R Lucas,João Delgado,Robin N Beaumont et al.
Mitchell R Lucas et al.
Background & aims: The iron overload disease haemochromatosis is primarily caused by HFE p.C282Y homozygosity, yet penetrance of clinical outcomes (including liver disease/cancer) varies. We aimed to estimate the effect o...
Radiation-induced lymphopenia is associated with survival in patients with hepatocellular carcinoma treated with stereotactic body radiotherapy [0.03%]
立体定向体放射治疗肝细胞癌的患者辐射引起的淋巴细胞减少与生存率相关
Landon L Chan,Vanessa T Y Yeung,Winnie M T Soo et al.
Landon L Chan et al.
Background & aims: Stereotactic body radiotherapy (SBRT) is increasingly used in the treatment of hepatocellular carcinoma (HCC). Severe radiation-induced lymphopenia (RIL) occurs in 30% to 40% of patients undergoing conv...
Multiomics and multi-region spatial transcriptome analysis reveal cellular networks and pathways associated with HCC recurrence [0.03%]
多组学和多区域空间转录组分析揭示与肝细胞癌复发相关的细胞网络和途径
Veerabrahma P Seshachalam,Ita N Sari,Kane Toh et al.
Veerabrahma P Seshachalam et al.
Background & aims: Hepatocellular carcinoma (HCC) exhibits diverse aetiologies and molecular heterogeneity, with a median 5-year overall survival of
Sleep deprivation drives hepatic steatosis via sympathetic sprouting-induced ER stress in young male mice [0.03%]
睡眠缺乏通过交感神经突触诱发的内质网应激驱动年轻小鼠肝脂肪变性
Kairui Pu,Yujing Zhao,Xiaoli Qu et al.
Kairui Pu et al.
Background & aims: Accumulating evidence indicates that sleep loss is significantly associated with an increased risk of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the underlying mechanisms...
Impact of Hepatocellular Carcinoma on the risk of liver decompensation: a comparative analysis of patients with and without HCC: Role of HCC in liver decompensation [0.03%]
肝细胞癌对肝失代偿风险的影响：有和没有肝细胞癌的患者比较分析：肝细胞癌在肝失代偿中的作用
Andrea Martini,Massimo Iavarone,Roberta D&#x;Ambrosio et al.
Andrea Martini et al.
Background & aims: Hepatocellular Carcinoma (HCC) is a leading cause of death and the large majority of HCC occurs in the setting of cirrhosis. Nevertheless, its impact on the development of decompensation in these patien...
Role of the stromal and immune microenvironment in intrahepatic cholangiocarcinoma [0.03%]
肝内胆管癌的间质和免疫微环境的作用
Silvia Affo,Daniela Sia
Silvia Affo
Intrahepatic cholangiocarcinoma (iCCA) represents one of the deadliest malignancies with an overall 5-year survival rate of 10%. For the past decades, surgery and chemotherapy have been the only option for early and late-stage disease, resp...
TCOF1 in Extracellular Vesicles predicts survival in HCC patients treated with High-Dose Conformal Radiotherapy [0.03%]
高剂量适形放射治疗肝癌患者中细胞外囊泡来源的TCOF1预测生存期
Daniel Puhr-Westerheide,Elif Öcal,Heidrun Hirner-Eppeneder et al.
Daniel Puhr-Westerheide et al.
Background & aims: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide. The lack of reliable biomarkers to predict treatment response limits patient stratification and personalized ther...