Disease-driven loss of inactive HSD17B13 isoforms enhances enzymatic output in MASH and counters protective rs72613567:TA variant [0.03%]
John Min,Mulugeta Seneshaw,Faridoddin Mirshahi et al.
John Min et al.
Background & aims: We investigated whether liver disease alters HSD17B13 isoform expression, identifying selective loss of exon 2-skipped variants and uncovering variant B as a structured, noncoding RNA with silencing pot...
Prognostic value of factor VIII, D-dimer and high molecular risk variants assessing re-thrombosis risk in non-cirrhotic portal vein thrombosis [0.03%]
Anna Baiges,Bogdan Procopet,Luis Téllez et al.
Anna Baiges et al.
Background & aims: Patients with non-cirrhotic non-tumoral portal venous system thrombosis (NCNT-PVT) require long-term anticoagulation to prevent rethrombosis (either splanchnic or at any site, referred to as overall ret...
Paediatric autoimmune liver disease in Europe, the prospective ERN R-Liver registry [0.03%]
欧洲儿科自身免疫性肝病，ERN R-Liver前瞻性登记处数据
Mikkel Malham,Gema Muñoz Bartolo,Antal Dezsöfi-Gottl et al.
Mikkel Malham et al.
Background & aims: Most literature on paediatric autoimmune liver disease (p-AILD) comprises single-centre, retrospective studies. This study aims to describe robust, real-world data for p-AILD during the first year follo...
Comparative performance of ReMELD-Na, MELD 3.0 and established scores after TIPS for refractory ascites: A multicenter study [0.03%]
经TIPS治疗难治性腹水后ReMELD-Na、MELD 3.0和其他评分系统的比较研究：一项多中心研究
Markus Kimmann,Nancy Farouk,Dominik Bettinger et al.
Markus Kimmann et al.
Background & aims: ReMELD-Na and MELD 3.0 are newly introduced prognostic scores for liver graft allocation, but their ability to predict outcomes after transjugular intrahepatic portosystemic shunt (TIPS) for refractory ...
H4K5 lactylation - ENO2 loop drives glycolysis and HCC progression [0.03%]
组蛋白H4K5乳酰化-丙酮酸激酶2别构结构域调控驱动糖酵解及肝癌进展
Masahiro Yamane,Yoshimitsu Akiyama,Shu Shimada et al.
Masahiro Yamane et al.
Background & aims: Histone lactylation is a lactate-dependent epigenetic modification driven by glycolysis. Although elevated histone lactylation occurs in various cancers, the biological relevance of histone H4 lactylati...
Chittampalli N Yashaswini,Ruchi Bansal
Chittampalli N Yashaswini
The endonuclease MCPIP1 protects against liver cancer development in a sex-dependent manner by modulating β-catenin and CREB1 [0.03%]
内切酶MCPIP1通过调节β-连环蛋白和CREB1以性别依赖性方式保护机体免于肝癌发生发展
Oliwia Kwapisz,Paulina Marona,Judyta Gorka et al.
Oliwia Kwapisz et al.
Background & aims: Monocyte chemoattractant protein-induced protein 1 (MCPIP1), encoded by ZC3H12A, is a negative regulator of inflammation and tumorigenesis. While its role has been implicated in various cancers, the fun...
Elebsiran and pegylated-IFNα: Progress toward a functional cure for chronic hepatitis B [0.03%]
在慢性乙型肝炎的功能性治愈方面，Elefsiran和聚乙二醇干扰素α的研究进展
Sara Battistella,Ulrike Protzer,Xavier Forns
Sara Battistella
EASL position paper on palliative care in advanced chronic liver disease [0.03%]
EASL关于终末期肝病姑息治疗的立场文件
Sumita Verma,Matthias Pinter,Lucia Macken et al.
Sumita Verma et al.
Deaths from advanced chronic liver disease have increased significantly across Europe, with most affected patients not receiving a liver transplant. Despite this increasing burden, inequities in the provision of palliative care persist. Man...
Practice Guideline
JHEP reports : innovation in hepatology. 2026 Apr;8(4):101686. DOI:10.1016/j.jhepr.2025.101686 2026
Cell-SELEX identifies a DNA aptamer for highly selective in vivo siRNA delivery in cholangiocarcinoma [0.03%]
细胞筛选DNA适配体用于肝内胆管癌中siRNA的体内特异性递送
Brandon A Wilbanks,Ayano Kabashima,Enis H Ozmert et al.
Brandon A Wilbanks et al.
Background & aims: Systematic evolution of ligands by exponential enrichment (SELEX) is a powerful technology for selecting tumor-targeting DNA aptamers from vast pools of trillions of randomly synthesized candidates. We ...