Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection [0.03%]
评估肝脏免疫学和病毒学反应：对治愈慢性乙型肝炎病毒感染的意义
Tobias Boettler,Upkar S Gill,Lena Allweiss et al.
Tobias Boettler et al.
Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that...
Deprescribing zolpidem reduces falls and fractures in patients with cirrhosis [0.03%]
减少肝硬化患者扎兰ピ地尔的使用可降低跌倒和骨折的风险
Elliot B Tapper,Zhe Zhao,G Scott Winder et al.
Elliot B Tapper et al.
Background & aims: Benzodiazepines are associated with an increased risk of harm in patients with cirrhosis. However, stopping benzodiazepines must be done with care to avoid withdrawal or other unintended consequences. T...
Bichitra Paul,Monika Lewinska,Jesper B Andersen
Bichitra Paul
Lipids are a complex and diverse group of molecules with crucial roles in many physiological processes, as well as in the onset, progression, and maintenance of cancers. Fatty acids and cholesterol are the building blocks of lipids, orchest...
High precision-cut liver slice model to study cell-autonomous antiviral defense of hepatocytes within their microenvironment [0.03%]
一种高精度切割的肝切片模型 在该模型中 肝细胞处于其微环境中 可以研究肝细胞自主抗病毒防御机制
Marcus Brugger,Melanie Laschinger,Sandra Lampl et al.
Marcus Brugger et al.
Background & aims: Increased sensitivity towards tumor necrosis factor (TNF)-induced cell death in virus-infected hepatocytes has revealed a so far unrecognized hepatocyte-intrinsic antiviral immune surveillance mechanism...
Nawras W Habash,Tejasav S Sehrawat,Vijay H Shah et al.
Nawras W Habash et al.
Alcohol-related liver disease (ARLD) is a primary cause of chronic liver disease in the United States. Despite advances in the diagnosis and management of ARLD, it remains a major public health problem associated with significant morbidity ...
Differential and organ-specific functions of organic solute transporter α and β in experimental cholestasis [0.03%]
有机溶质转运蛋白α和β在实验性胆汁淤积中的差异和器官特异性功能
Sandra M W van de Wiel,Begoña Porteiro,Saskia C Belt et al.
Sandra M W van de Wiel et al.
Background & aims: Organic solute transporter (OST) subunits OSTα and OSTβ facilitate bile acid efflux from the enterocyte into the portal circulation. Patients with deficiency of OSTα or OSTβ display considerable var...
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease [0.03%]
非酒精性脂肪肝病全范围内的代谢标志物
Aidan J McGlinchey,Olivier Govaere,Dawei Geng et al.
Aidan J McGlinchey et al.
Background & aims: Non-alcoholic fatty liver disease (NAFLD) is a progressive liver disease with potentially severe complications including cirrhosis and hepatocellular carcinoma. Previously, we have identified circulatin...
Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals [0.03%]
直接抗病毒药物使用十年后国际肝炎C病毒耐药性队列的特征研究
Anita Y M Howe,Chaturaka Rodrigo,Evan B Cunningham et al.
Anita Y M Howe et al.
Background & aims: Direct-acting antiviral (DAA) regimens provide a cure in >95% of patients with chronic HCV infection. However, in some patients in whom therapy fails, resistance-associated substitutions (RASs) can deve...
Mindfulness-based stress reduction may decrease stress, disease activity, and inflammatory cytokine levels in patients with autoimmune hepatitis [0.03%]
基于心理冥想的压力缓解方法可能降低自身免疫性肝炎患者的压力、疾病活跃程度及炎症细胞因子水平
Leina S Alrabadi,Anne Dutton,Anahita Rabiee et al.
Leina S Alrabadi et al.
Background & aims: Psychological and life stressors may impact autoimmune hepatitis (AIH) disease activity and increase relapse risk. Mindfulness-based stress reduction (MBSR) is a validated course that reduces stress rea...