Agrin Moeini,Philipp K Haber,Daniela Sia
Agrin Moeini
Biliary tract cancers (BTCs) are aggressive epithelial malignancies that can arise at any point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising steadily over the past 40 years, highlighting the need to...
Balance between macrophage migration inhibitory factor and sCD74 predicts outcome in patients with acute decompensation of cirrhosis [0.03%]
巨噬细胞迁移抑制因子与sCD74的平衡预测肝硬化急性失代偿患者的预后
Theresa H Wirtz,Philipp A Reuken,Christian Jansen et al.
Theresa H Wirtz et al.
Background & aims: Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine and an important regulator of innate immune responses. We hypothesised that serum concentrations of MIF are associated with disea...
Jerome Boursier,Emmanuel A Tsochatzis
Jerome Boursier
Among the large population of patients with non-alcoholic fatty liver disease (NAFLD), identifying those with advanced disease remains challenging. Many patients are diagnosed late, following the development of liver-related complications, ...
Assessing the periprocedural magnitude of platelet count change in response to lusutrombopag [0.03%]
评估lusutrombopag对围操作期血小板计数变化的影响大小
Robert S Brown Jr,Michio Imawari,Namiki Izumi et al.
Robert S Brown Jr et al.
Background & aims: Despite limitations, platelet transfusion has been used to minimise bleeding risk in patients with thrombocytopaenia. Lusutrombopag is an oral, thrombopoietin receptor agonist approved for treatment of ...
Assessing the impact of COVID-19 on liver cancer management (CERO-19) [0.03%]
评估COVID-19大流行对肝细胞癌管理的影响(CERO-19)研究
Sergio Muñoz-Martínez,Victor Sapena,Alejandro Forner et al.
Sergio Muñoz-Martínez et al.
Background & aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether t...
Abnormal liver tests in patients with SARS-CoV-2 or influenza - prognostic similarities and temporal disparities [0.03%]
SARS-CoV-2或流感患者的肝脏转氨酶异常升高：预后相似性与时间差异性
Noa Shafran,Assaf Issachar,Tzippy Shochat et al.
Noa Shafran et al.
Background & aims: Abnormal liver tests are common in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but a possible direct role of the virus in liver injury and its association with ...
NASH-related increases in plasma bile acid levels depend on insulin resistance [0.03%]
与2型糖尿病和非酒精性脂肪肝病相关的胆汁酸水平变化及其对肝脏胰岛素抵抗的影响
Guillaume Grzych,Oscar Chávez-Talavera,Amandine Descat et al.
Guillaume Grzych et al.
Background & aims: Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the associatio...
Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade [0.03%]
化疗诱导的髓系衍生抑制细胞招募消除免疫检查点阻断的效果
Tsz Tung Kwong,Chi Hang Wong,Jing Ying Zhou et al.
Tsz Tung Kwong et al.
Background & aims: Immune checkpoint blockade (ICB) has been approved for treatment of hepatocellular carcinoma (HCC). However, many patients with advanced HCC are non-responders to ICB monotherapy. Cytotoxic chemotherapy...
ZBTB20 regulates WNT/CTNNB1 signalling pathway by suppressing PPARG during hepatocellular carcinoma tumourigenesis [0.03%]
ZBTB20通过抑制PPARG调节WNT/CTNNB1信号通路以促进肝细胞癌发生发展
Jeffrey C To,Amy P Chiu,Barbara R Tschida et al.
Jeffrey C To et al.
Background & aims: Zinc finger and BTB domain containing 20 (ZBTB20) has been implicated as a potential oncogene in liver cancer. However, knockout studies have shown it to be a transcriptional repressor of the alpha-foet...
TGR5 controls bile acid composition and gallbladder function to protect the liver from bile acid overload [0.03%]
TGR5通过调控胆汁酸组成和胆囊排空来保护肝脏免受胆汁酸过载损伤
Valeska Bidault-Jourdainne,Grégory Merlen,Mathilde Glénisson et al.
Valeska Bidault-Jourdainne et al.
Background & aims: As the composition of the bile acid (BA) pool has a major impact on liver pathophysiology, we studied its regulation by the BA receptor Takeda G protein coupled receptor (TGR5), which promotes hepatopro...