Ultrasound remission after biologic induction and long-term endoscopic remission in Crohn's disease: a prospective cohort study [0.03%]
生物制剂诱导和克罗恩病长期内镜缓解的超声缓解:前瞻性队列研究
Mariangela Allocca,Cecilia DellAvalle,Alessandra Zilli et al.
Mariangela Allocca et al.
Background: The Bowel Ultrasound Score (BUSS) accurately detects therapy-related changes by using the Simple Endoscopic Score for Crohn's disease (SES-CD) as the reference standard. We aimed to evaluate ultrasound remissi...
Stakeholder perspectives towards diagnostic artificial intelligence: a co-produced qualitative evidence synthesis [0.03%]
利益相关者视角下的诊断型人工智能:一种共生成的定性证据综合分析法
Rachel Yi Ling Kuo,Alexander Freethy,Judi Smith et al.
Rachel Yi Ling Kuo et al.
Background: Diagnosis is a cornerstone of medical practice. Worldwide, there is increased demand for diagnostic services, exacerbating workforce shortages. Artificial intelligence (AI) technologies may improve diagnostic ...
Prevalence of aggressive care among patients with cancer near the end of life: a systematic review and meta-analysis [0.03%]
临终癌症患者的过度治疗:系统评价和荟萃分析
Zhuo Ma,Huangqianyu Li,Yi Zhang et al.
Zhuo Ma et al.
Background: Aggressive care near patients' end-of-life (EOL) entails limited therapeutic values, high costs, and compromised quality of life (QoL). In this study, we aimed to estimate the global prevalence of aggressive c...
Long-term impact of home-based monitoring after an admission for acute decompensated heart failure: a systematic review and meta-analysis of randomised controlled trials [0.03%]
急性心力衰竭住院后长期进行家庭监护的效果:系统评价和-meta-分析
Mariana R C Clemente,Nicole Felix,Denilsa D P Navalha et al.
Mariana R C Clemente et al.
Background: Patients with heart failure have high rehospitalisation rates and poor cardiovascular outcomes. Home-based monitoring (HBM) has emerged with promising results in different settings. However, its long-term effe...
Predicting skin cancer risk from facial images with an explainable artificial intelligence (XAI) based approach: a proof-of-concept study [0.03%]
基于可解释的人工智能(XAI)方法从面部图像中预测皮肤癌风险的概念验证研究
Xianjing Liu,Tobias E Sangers,Tamar Nijsten et al.
Xianjing Liu et al.
Background: Efficient identification of individuals at high risk of skin cancer is crucial for implementing personalized screening strategies and subsequent care. While Artificial Intelligence holds promising potential fo...
Comparison of long-term outcome between clinically high risk lobular versus ductal breast cancer: a propensity score matched study [0.03%]
临床高危乳腺癌患者预后分析:导管型和小叶型哪种更差?倾向匹配评分分析
Francesca Magnoni,Giovanni Corso,Patrick Maisonneuve et al.
Francesca Magnoni et al.
Background: Abemaciclib is currently approved for the adjuvant treatment of high-risk, lymph node (LN)-positive, hormone receptor (HR)-positive breast cancer (BC). In a real-world setting the clinicopathologic features of...
The potential epidemiologic, clinical, and economic value of a universal coronavirus vaccine: a modelling study [0.03%]
通用型冠状病毒疫苗的潜在流行病学、临床和经济效益:建模研究
Sarah M Bartsch,Kelly J OShea,Danielle C John et al.
Sarah M Bartsch et al.
Background: With efforts underway to develop a universal coronavirus vaccine, otherwise known as a pan-coronavirus vaccine, this is the time to offer potential funders, researchers, and manufacturers guidance on the poten...
Efficacy and safety of phospholipid nanoparticles (VBI-S) in reversing intractable hypotension in patients with septic shock: a multicentre, open-label, repeated measures, phase 2a clinical pilot trial [0.03%]
卵磷脂纳米颗粒(VBI-S)逆转脓毒性休克患者难治性低血压的有效性和安全性:一项多中心、开放标签、重复测量、IIa期临床试点试验
Cuthbert Simpkins,Michael Moncure,Heather Klepacz et al.
Cuthbert Simpkins et al.
Background: Since the 1990's attempts to favorably modulate nitric oxide (NO) have been unsuccessful. We hypothesized that because NO is lipophilic it would preferentially localize into intravascularly infused hydrophobic...
Effect of human milk-based fortification in extremely preterm infants fed exclusively with breast milk: a randomised controlled trial [0.03%]
基于人乳的强化剂对仅接受母乳喂养的极早产婴儿的影响:一项随机对照试验
Georg Bach Jensen,Magnus Domellöf,Fredrik Ahlsson et al.
Georg Bach Jensen et al.
Background: Mortality and severe morbidity remain high in extremely preterm infants. Human milk-based nutrient fortifiers may prevent serious complications and death. We aimed to investigate whether supplementation with h...
Efficacy of oral 20-hydroxyecdysone (BIO101), a MAS receptor activator, in adults with severe COVID-19 (COVA): a randomized, placebo-controlled, phase 2/3 trial [0.03%]
口服20-羟基蜕皮酮(BIO101),一种MAS受体激动剂,用于治疗成人重度COVID-19患者的疗效:一项随机、双盲、安慰剂对照的II/III期临床试验
Suzana Margareth Lobo,Gaétan Plantefève,Girish Nair et al.
Suzana Margareth Lobo et al.
Background: SARS-CoV-2 binding to ACE2 is potentially associated with severe pneumonia due to COVID-19. The aim of the study was to test whether Mas-receptor activation by 20-hydroxyecdysone (BIO101) could restore the Ren...