Pre-pregnancy weight in Swedish women and the risk of gestational diabetes and subsequent type 2 diabetes-a population-based cohort study [0.03%]
Jon Edqvist,Annika Rosengren,Demir Djekic et al.
Jon Edqvist et al.
Background: Obesity in young women is increasing. To which extent elevated pre-pregnancy overweight and obesity with and without gestational diabetes increase long-term risk of type 2 diabetes later in life has not been q...
Fraction dose escalation of split-course concurrent chemoradiotherapy following induction chemo-immunotherapy in unresectable locally advanced oesophageal squamous carcinoma in China (GASTO-10102): a single-centre phase 1 study [0.03%]
FangJie Liu,DaQuan Wang,GuangYu Luo et al.
FangJie Liu et al.
Background: The optimal fractionation patterns and safety of hypofractionated radiotherapy remain poorly defined in locally advanced oesophageal squamous cell carcinoma (LA-ESCC). We aimed to determine the maximum tolerat...
The association between vaccine coverage and herd protection: exploratory analyses of a cluster-randomised trial of Vi conjugate vaccine [0.03%]
Yiyuan Zhang,Faisal Ahmmed,Farhana Khanam et al.
Yiyuan Zhang et al.
Background: Indirect protection from the typhoid conjugate vaccine (TCV) has been negligible, possibly due to vaccination being restricted to children, which may have limited the overall vaccine coverage needed to suffici...
Hip displacement management in spinal muscular atrophy in the era of disease modifying therapies: a Delphi consensus study in the UK [0.03%]
Maria I Vanegas,Giovanni Baranello,Fabian Norman-Taylor et al.
Maria I Vanegas et al.
Background: Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by bi-allelic deletions or pathogenic variants in the SMN1 gene. SMA type 1 is the most severe form with early muscle weakness, failure ...
Outcome measurement instruments for the core outcome sets on genital gender-affirming surgery: the GenderCOS project [0.03%]
Matteo Angelini,Philippine J Roijer,Marleen S Vallinga et al.
Matteo Angelini et al.
Background: Outcome assessment in genital gender-affirming surgery (gGAS) has long been a heterogenous practice. Although two core outcome sets (COS) for masculinizing and feminizing gGAS have been previously established,...
Effectiveness and safety of selective internal radiation therapy using yttrium-90 glass microspheres for hepatocellular carcinoma: real-world results from the multi-center prospective PROACTIF cohort of 989 patients [0.03%]
Boris Guiu,Clément Bailly,Eric Vibert et al.
Boris Guiu et al.
Background: Selective Internal Radiation Therapy with yttrium-90 (Y90) has been used for decades, yet guideline recommendations remain inconsistent. High-quality real-world data is needed to guide practice. The objectives...
"Magical relief": the effectiveness of three stages of a video-based magic intervention on distress and pain in children aged 9-11 years during HPV mass vaccinations-a cluster-randomized trial [0.03%]
Anne W E Versluis,Edmond H H M Rings,Arno A W Roest et al.
Anne W E Versluis et al.
Background: Vaccinations often elicit significant distress in school-aged children, which can impact pain perception and future medical experiences. This study examined the effects of three stages of a video-based magic i...
Metformin and epigenetic age in non-diabetic older people with HIV in Madrid (METFORAGING): a double-blind, randomised, placebo-controlled, pilot trial [0.03%]
Cristina Marcelo-Calvo,Andrés Esteban-Cantos,Francisco Jurado et al.
Cristina Marcelo-Calvo et al.
Background: Metformin is increasingly studied as a potential geroprotective agent in the general population. We aimed to test the efficacy and safety of metformin to improve epigenetic age in older, well-controlled, non-d...
Safety and efficacy of intravenous onasemnogene abeparvovec gene therapy in patients with spinal muscular atrophy type 1: interim analysis from LT-001, a long-term follow-up study of patients from the START study [0.03%]
Megan A Waldrop,Roberto Bernardo Escudero,Lina Yang et al.
Megan A Waldrop et al.
Background: LT-001 evaluated long-term safety/efficacy of onasemnogene abeparvovec (OA) for spinal muscular atrophy (SMA) patients from START (N = 15; NCT02122952). ...
Pharmacokinetics and pharmacodynamics of valganciclovir in infants with severe HIV-associated pneumonia in Africa: a sub-study of the EMPIRICAL randomised controlled trial [0.03%]
Tom G Jacobs,Vivian Mumbiro,John Tembo et al.
Tom G Jacobs et al.
Background: Cytomegalovirus (CMV) is a major unrecognised cause of morbidity and mortality in infants living with HIV. Valganciclovir, an oral prodrug of ganciclovir, treats CMV in immunocompromised patients, but pharmaco...