Shorter versus longer-duration antibiotic treatments for immunocompetent patients with bloodstream infections: a Bayesian perspective [0.03%]
免疫功能正常的血液感染患者的抗生素短程治疗与长程治疗：贝叶斯学派的观点
Ruslan Akhmedullin,Abduzhappar Gaipov
Ruslan Akhmedullin
Rethinking the WHO AWaRe classification: the need for more detailed guidance [0.03%]
重新考虑世卫组织AWaRe分类：需要更多详细的指导方针
Shinya Tsuzuki,Ryuji Koizumi,Kensuke Aoyagi et al.
Shinya Tsuzuki et al.
The World Health Organization's Access, Watch, and Reserve (AWaRe) classification promotes appropriate antibiotic use and is widely adopted as a global indicator of antimicrobial use (AMU) quality. This paper highlights key limitations of t...
Muhammad Saghir Khan,Daisuke Tomizawa,Huyung Zheng et al.
Muhammad Saghir Khan et al.
In this second paper of a Series on childhood cancer in Asia, we provide an overview on the Paediatric Oncology Clinical Trials in Asia. Asia with a population of 4.7 billion constitutes about 60% of the world's population. The continent ac...
Measles seropositivity in previously vaccinated individuals: a systematic review and meta-analysis [0.03%]
既往接种过疫苗的人群中的 measles 抗体阳性率的系统综述和meta分析
Mohammed Mustafa,Alex S Reznik,Juan Uribe et al.
Mohammed Mustafa et al.
Background: With the resurgence of measles outbreaks globally it is important to understand how seropositivity induced by measles vaccination wanes over time. We aimed to measure the prevalence of measles seropositivity i...
An anti-inflammatory reliever algorithm approach to asthma management in adults: an open-label, single-arm trial [0.03%]
成人哮喘管理的抗炎缓解算法方法：一项开放标签单臂试验
Pepa Bruce,Claire Houghton,Lee Hatter et al.
Pepa Bruce et al.
Background: The stepwise approach to asthma management is a key feature of guidelines, yet knowledge of its implementation in clinical practice is limited. Our objective was to evaluate the implementation of an anti-infla...
eClinicalMedicine
eClinicalMedicine
Regular use of pharmaceutical opioids and subsequent risk of cancer: a prospective cohort study and Mendelian randomization analysis [0.03%]
阿片类药物的常规使用与癌症风险增加的关系：前瞻性队列研究和孟德尔随机化分析
Mahdi Sheikh,Allison Domingues,Karine Alcala et al.
Mahdi Sheikh et al.
Background: Opium consumption was classified as "carcinogenic to humans" by the International Agency for Research on Cancer (IARC). We investigated whether use of pharmaceutical opioids, derived from or synthesized to mim...
Two-year outcomes after early postnatal high-dose fat-soluble enteral vitamin A supplementation in extremely low birth weight infants: follow-up of the NeoVitaA randomized controlled trial [0.03%]
极低出生体重婴儿早期高剂量脂溶性维生素A补充的两年随访：NeoVitaA随机对照试验的后续研究
Martin Poryo,Ludwig Gortner,Johannes Bay et al.
Martin Poryo et al.
Background: The longer-term effects of early high-dose vitamin A to support lung development in preterm infants remain to be clarified. The aim of the NeoVitaA follow-up study was to assess the effects of early postnatal ...
Metacognitive therapy and work-focus for patients with depression, anxiety or comorbid depression and anxiety on sick leave: a single-centre, open-label randomised controlled trial [0.03%]
针对病假期间患有抑郁症、焦虑症或共病的患者的元认知治疗和工作导向性研究：一项单中心开放标签随机对照试验
Ragne G H Gjengedal,Marit Hannisdal,Kåre Osnes et al.
Ragne G H Gjengedal et al.
Background: Employment is a key determinant of health, but mental health treatments have limited success on return-to-work (RTW) in depression and anxiety. We investigated the effectiveness of metacognitive therapy combin...
Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies [0.03%]
抑郁症遗传易感性与心血管代谢性疾病风险之间的关系：基于21项孟德尔随机化研究的系统评价和meta分析
Tabinda Jabeen,Emma Todd,Sarah Gauci et al.
Tabinda Jabeen et al.
Background: Depression is a risk factor for cardiometabolic diseases, but the extent to which this is attributable to genetic (rather than environmental) factors is unclear. Mendelian randomisation (MR) uses genetic varia...