Safety and immunogenicity of a single dose of Tdap compared to Td in pregnant women in Mali and 3 its effect on infant immune responses: a single-centre, randomised, double-blind, active-controlled phase 2 study [0.03%]
单剂次Td和Tdap疫苗在马里的孕妇中的安全性和免疫原性及其对婴儿的影响：一项中心单一剂量、随机对照、双盲 II 期试验
Fadima Cheick Haidara,Milagritos D Tapia,Fatoumata Diallo et al.
Fadima Cheick Haidara et al.
Background: While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed to evaluate the safety of a single dose of tetanus, dip...
Sustainability and impact of an intervention to improve initiation of tuberculosis preventive treatment: results from a follow-up study of the ACT4 randomized trial [0.03%]
改善结核病预防治疗启动干预措施的可持续性和影响：来自ACT4随机对照试验随访研究的结果
Dick Menzies,Joseph Obeng,Panji Hadisoemarto et al.
Dick Menzies et al.
Background: In a cluster randomized trial (clinicaltrials.gov: NCT02810678) a flexible but comprehensive health system intervention significantly increased the number of household contacts (HHC) identified and started on ...
Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial [0.03%]
一项多中心、双盲、随机对照的Ⅱ期临床试验：RBT-1对冠状动脉旁路移植或心脏瓣膜手术患者预适应反应生物标志物的影响
Andre Lamy,Glenn M Chertow,Michael Jessen et al.
Andre Lamy et al.
Background: RBT-1 is a combination drug of stannic protoporfin (SnPP) and iron sucrose (FeS) that elicits a preconditioning response through activation of antioxidant, anti-inflammatory, and iron-scavenging pathways, as m...
Maternal-fetal outcomes in patients with immune-mediated inflammatory diseases, with consideration of comorbidities: a retrospective cohort study in a large U.S. healthcare system [0.03%]
自身免疫性炎症性疾病患者的母婴结局（兼顾合并症）：美国一医疗系统的回顾队列研究
Yeon Mi Hwang,Qi Wei,Samantha N Piekos et al.
Yeon Mi Hwang et al.
Background: Immune-mediated inflammatory diseases (IMIDs) are likely to complicate maternal health. However, literature on patients with IMIDs undergoing pregnancy is scarce and often overlooks the presence of comorbiditi...
eClinicalMedicine
eClinicalMedicine
PTSD, depression, and anxiety after the October 7, 2023 attack in Israel: a nationwide prospective study [0.03%]
2023年10月7日以色列袭击后的 PTSD、抑郁和焦虑：一项全国前瞻性研究
Yossi Levi-Belz,Yoav Groweiss,Carmel Blank et al.
Yossi Levi-Belz et al.
Background: The magnitude of the Oct 7, 2023 attack in southern Israel was without precedent. More than 1300 civilians were murdered, and 240 civilians were kidnapped and taken hostage. In this national cohort study, for ...
Ultra-processed food consumption and mortality among patients with stages I-III colorectal cancer: a prospective cohort study [0.03%]
加工食品摄入量与I-III期结直肠癌患者的死亡率：一项前瞻性队列研究
Dong Hang,Mengxi Du,Lu Wang et al.
Dong Hang et al.
Background: Ultra-processed foods (UPFs) are emerging as a risk factor for colorectal cancer (CRC), yet how post-diagnostic UPF intake may impact CRC prognosis remains unexplored. ...
Effect of level of sedation on outcomes in critically ill adult patients: a systematic review of clinical trials with meta-analysis and trial sequential analysis [0.03%]
镇静程度对重症成人患者预后影响的系统评价和meta分析及试验序贯分析
Ameldina Ceric,Johan Holgersson,Teresa L May et al.
Ameldina Ceric et al.
Background: Sedation is routinely administered to critically ill patients to alleviate anxiety, discomfort, and patient-ventilator asynchrony. However, it must be balanced against risks such as delirium and prolonged inte...
Dabrafenib plus trametinib versus anti-PD-1 monotherapy as adjuvant therapy in BRAF V600-mutant stage III melanoma after definitive surgery: a multicenter, retrospective cohort study [0.03%]
达拉菲尼联合曲美替尼与抗PD-1单药治疗作为 BRAF V600突变阳性III期黑色素瘤术后辅助治疗的多中心回顾性队列研究
Xue Bai,Ahmed Shaheen,Charlotte Grieco et al.
Xue Bai et al.
Published Erratum
EClinicalMedicine. 2024 Mar 27:71:102564. DOI:10.1016/j.eclinm.2024.102564 2024
Clinical spectrum and evolution of immune-checkpoint inhibitors toxicities over a decade-a worldwide perspective [0.03%]
十年来全球免疫检查点抑制剂的临床谱系及毒性演变状况分析
Paul Gougis,Floriane Jochum,Baptiste Abbar et al.
Paul Gougis et al.
Background: Immune-checkpoint inhibitors (ICI) have revolutionized cancer treatment by harnessing the immune system but ICI can induce life-threatening immune-related adverse events (irAE) affecting every organ. ...