Camrelizumab, chemotherapy and apatinib in the neoadjuvant treatment of resectable oesophageal squamous cell carcinoma: a single-arm phase 2 trial [0.03%]
卡瑞利珠单抗联合化疗和阿帕替尼用于可切除食管鳞癌新辅助治疗的Ⅱ期单臂研究
Zixiang Wu,Chuanqiang Wu,Jing Zhao et al.
Zixiang Wu et al.
Background: In resectable oesophageal squamous cell carcinoma (ESCC), the efficacy of camrelizumab combined with chemotherapy and apatinib followed by minimally invasive oesophagectomy is not clear. We aimed to fill this ...
Efficacy and safety of GST-HG171 in adult patients with mild to moderate COVID-19: a randomised, double-blind, placebo-controlled phase 2/3 trial [0.03%]
GST-HG171治疗成人轻中型新型冠状病毒肺炎有效性和安全性的随机、双盲、安慰剂对照II/III期临床试验
Hongzhou Lu,George Zhang,John Mao et al.
Hongzhou Lu et al.
Background: GST-HG171 is a potent, broad-spectrum, orally bioavailable small-molecule 3C like protease inhibitor that has demonstrated greater potency and efficacy compared to Nirmatrelvir in pre-clinical studies. We aime...
Association between concurrence of multiple risk factors and under-5 mortality: a pooled analysis of data from Demographic and Health Survey in 61 low-and-middle-income countries [0.03%]
低收入和中等收入国家61个人口与健康调查数据的汇总分析：多种危险因素并存与五岁以下儿童死亡率之间的关系
Yuhao Kong,Shaoru Chen,Ning Ma et al.
Yuhao Kong et al.
Background: Exposure to multiple risk factors is prevalent in low-and middle-income countries (LMICs), challenging one-directional strategies to address preventable under-5 mortality (U5M). This study aims to assess the a...
Child, maternal, and adult mortality in rural Ethiopia in 2019: a cross-sectional mortality survey using electronic verbal autopsies [0.03%]
2019年电子形式口头尸检调查下的埃塞俄比亚农村地区的儿童、产妇及成人死亡率：一项横断面死亡调查研究
Wubegzier Mekonnen,Damen Haile Mariam,Catherine Meh et al.
Wubegzier Mekonnen et al.
Background: Ethiopia, with about 10% of Africa's population, has little direct information on causes of death, particularly in rural areas where 80% of Ethiopians live. In 2019-2020, we conducted electronic verbal autopsi...
Prevalence and determinants of constipation in children in Asia: a systematic review and meta-analysis [0.03%]
亚洲儿童便秘流行病学及影响因素的系统评价和meta分析研究
Felicia Djurijanto,Shyh-Hsiang Lin,Nguyen-Phong Vo et al.
Felicia Djurijanto et al.
Background: Constipation is prevalent worldwide, significantly increasing healthcare costs and diminishing the quality of life in children affected. Current studies have yielded mixed results regarding the factors associa...
The burden of hospital-acquired infections (HAI) in sub-Saharan Africa: a systematic review and meta-analysis [0.03%]
非洲撒哈拉以南地区医院内感染的负担：系统评价和荟萃分析
Herbert Melariri,Robert Freercks,Elizabeth van der Merwe et al.
Herbert Melariri et al.
Background: Hospital-acquired infections (HAI) are a leading cause of morbidity and mortality globally. These infections are diverse, but the majority are lower respiratory tract infection (LRTI), surgical site infection ...
Effectiveness and safety of tetracyclines and quinolones in people with Mycoplasma pneumonia: a systematic review and network meta-analysis [0.03%]
治疗支原体肺炎四环素类和喹诺酮类药物有效性和安全性的系统评价和网络 meta 分析
Fangqing Cai,Jinglin Li,Weijie Liang et al.
Fangqing Cai et al.
Background: The escalating resistance of Mycoplasma pneumoniae to macrolides has become a significant global health concern, particularly in low-income and middle-income countries (LMICs). Although tetracyclines and quino...
Maternal education and its influence on child growth and nutritional status during the first two years of life: a systematic review and meta-analysis [0.03%]
母亲教育程度及其对生命头两年儿童生长发育和营养状况的影响：系统评价和-meta-分析
Golnaz Rezaeizadeh,Mohammad Ali Mansournia,Abbasali Keshtkar et al.
Golnaz Rezaeizadeh et al.
Background: The first 1000 days of life are critical for a child's health and development. Impaired growth during this period is linked to increased child morbidity, mortality, and long-term consequences. Undernutrition i...
Vasiliki Kentrou,Lucy A Livingston,Rachel Grove et al.
Vasiliki Kentrou et al.
Background: Many autistic people, particularly women, do not receive an autism diagnosis until adulthood, delaying their access to timely support and clinical care. One possible explanation is that autistic traits may ini...
Clinical outcomes following discontinuation of metformin in patients with type 2 diabetes and advanced chronic kidney disease in Hong Kong: a territory-wide, retrospective cohort and target trial emulation study [0.03%]
香港二型糖尿病伴晚期慢性肾脏病患者停用二甲双胍后的临床结局：一项全港范围的回顾性队列研究及目标试验仿真研究
Aimin Yang,Mai Shi,Hongjiang Wu et al.
Aimin Yang et al.
Background: Current labelling advises discontinuation of metformin when estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 due to increased risk of lactic acidosis. However, in real-world practice, the risk-b...