Mapping diversity in gender identity and gender roles across sex and age in the Dutch general population: a large-scale cohort study [0.03%]
荷兰普通人群中的性别身份和性角色的多样性：一项大规模队列研究
Sarah M Burke,Daniëlle B A Kroeze,S Lucette Kiewiet et al.
Sarah M Burke et al.
Background: Knowledge of diversity in gender identity and gender roles in the general population is limited. This study aimed to report the prevalence estimates of gender identity and gender roles among the adult general ...
Radiation dose escalation in locally advanced oesophageal cancer: a systematic review and hierarchical Bayesian meta-analysis [0.03%]
局部晚期食管癌放射治疗剂量递增的系统性回顾及分层贝叶斯meta分析
Yang-Hong Dai,Po-Huang Chen,Yi-Jhih Huang et al.
Yang-Hong Dai et al.
Background: The impact of radiation dose escalation in locally advanced oesophageal cancer remains controversial. While higher doses may improve locoregional control, their effect on overall survival (OS) and progression-...
Delivery of care in high mortality hospital settings: a direct observational study examining 1848 h of neonatal nursing in Kenya [0.03%]
在高住院死亡率背景下护理的实施：一项直接观察性研究，在肯尼亚观察1848小时新生儿护理
Abdulazeez Imam,Michuki Maina,Jalemba Aluvaala et al.
Abdulazeez Imam et al.
Background: In resource-constrained countries, deploying better technologies is expected to improve neonatal care but little attention has been paid to the critical role of nurse staffing. We investigate nursing workloads...
Efficacy and safety of neoadjuvant toripalimab plus chemotherapy in localized deficient mismatch repair/microsatellite instability-high gastric or esophagogastric junction adenocarcinoma (NICE): a multicentre, single-arm, exploratory phase 2 study [0.03%]
特瑞普利单抗联合化疗新辅助治疗局晚期dMMR/ MSI-H胃癌或食管胃交界部腺癌的疗效和安全性：一项多中心、单组、探索性Ⅱ期研究
Liying Zhao,Hao Liu,Jiang Yu et al.
Liying Zhao et al.
Background: In locally advanced gastric or gastroesophageal junction adenocarcinoma (GC/EGJC), deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H) tumors exhibit high responsiveness to immunotherapy. Th...
A European Association for Palliative Care White Paper defining an integrative palliative, geriatric, and rehabilitative approach to care and support for older people living with frailty and their family carers: a 28-country Delphi study and recommendations [0.03%]
欧洲缓和医疗协会白皮书：定义了一种综合的缓和、老年及康复护理模式，用以照料脆弱老年人及其家庭照顾者：一项涵盖28个国家的德尔菲研究与建议
Lieve Van den Block,Kim de Nooijer,Sophie Pautex et al.
Lieve Van den Block et al.
Background: A fast-growing number of older people living with frailty experience complex needs throughout their illness trajectory. However, currently, there is no international consensus on optimal care and support to ol...
Cord red blood cell transfusions for severe retinopathy in preterm neonates in Italy: a multicenter randomized controlled trial [0.03%]
意大利早产儿严重视网膜病的输血疗法：一项多中心随机对照试验
Luciana Teofili,Patrizia Papacci,Claudio Pellegrino et al.
Luciana Teofili et al.
Background: Red blood cell (RBC) transfusions in preterm neonates are associated with retinopathy of prematurity (ROP). Methods: BORN i...
Circulating tumour cells & circulating tumour DNA in patients with resectable colorectal liver metastases (MIRACLE): a prospective, observational biomarker study [0.03%]
可切除结直肠癌肝转移患者中循环肿瘤细胞及循环肿瘤DNA的研究（MIRACLE）：一项前瞻性观察性生物标志物研究
Lissa Wullaert,Maurice P H M Jansen,Jaco Kraan et al.
Lissa Wullaert et al.
Background: Recurrence risk after curative surgery for colorectal liver metastases (CRLM) remains high, underlining the need to identify prognostic markers enabling more individualised treatment approaches. ...
Safety and efficacy of MCO-010 optogenetic therapy in patients with Stargardt disease in USA (STARLIGHT): an open-label multi-center Ph2 trial [0.03%]
MCO-010光遗传疗法在美国Stargardt病患者中的安全性和有效性：一项开放标签的多中心Ⅱ期临床试验（STARLIGHT研究）
Byron L Lam,Vitaliy Zak,Victor H Gonzalez et al.
Byron L Lam et al.
Background: Stargardt disease (SD) is an inherited degenerative retinal disease affecting rod and cone photoreceptors and retinal pigment epithelial (RPE) cells, leading to severe and irreversible vision loss. Optogenetic...
Impact of treatment suspension on health-related quality of life in the EMBARK trial: a post hoc analysis [0.03%]
EMBARK试验中治疗中断对患者生活质量影响的探索性分析
Stephen J Freedland,Ugo De Giorgi,Antti Rannikko et al.
Stephen J Freedland et al.
Background: Enzalutamide was approved for high-risk biochemically recurrent (hrBCR) prostate cancer based on the EMBARK trial (NCT02319837; 17 December 2014-31 January 2023). In EMBARK, treatment was suspended at week 37 ...
Impact of social protection on child malnutrition and mortality across 46 LMICs: a longitudinal study over two decades with insights from the COVID-19 pandemic [0.03%]
社会保障对46个中低收入国家儿童营养不良和死亡率的二十年纵向研究及COVID-19疫情带来的启示
Elisa Landin Basterra,Ugo Gentilini,Daniella Medeiros Cavalcanti et al.
Elisa Landin Basterra et al.
Background: Under-5 mortality and malnutrition are major public health challenges in low- and middle-income countries (LMICs), worsened by crises like the COVID-19 pandemic. Evidence on social protection reducing under-5 ...