Daratumumab in patients with immune thrombocytopenia: a single-center, open-label, phase 2 trial [0.03%]
达雷妥尤单抗治疗免疫性血小板减少症患者：一项单中心、开放标记、II期临床试验
Yunfei Chen,Zhengjie Hua,Yanmei Xu et al.
Yunfei Chen et al.
Background: Immune thrombocytopenia is an autoimmune bleeding disorder. Daratumumab, a human monoclonal antibody targeting CD38 glycoprotein, is currently under clinical investigation as a potential therapy for autoimmune...
Accounting for conversion surgery and ctDNA cut-points in DRAGON-09 [0.03%]
DRAGON-09中转化手术及ctDNA切割点的考量
Zhenghao Cai,Xinyu Jiang,Dingxiang Li
Zhenghao Cai
Chemsex and uptake of HIV pre-exposure prophylaxis among adult cisgender gay, bisexual and other men who have sex with men worldwide: a systematic review with meta-analysis [0.03%]
全球成人顺性别男同性恋、男双性恋和其他男男性行为者中化学性交与HIV暴露前预防的使用：系统评价和meta分析
Joan Gil Miñana,Sonia Arias García,Elisa De Lazzari et al.
Joan Gil Miñana et al.
Background: There is a lack of summarized information regarding the uptake of pre-exposure prophylaxis (PrEP) among HIV negative gay, bisexual and other men who have sex with men (GBMSM) who engage in chemsex. This system...
eClinicalMedicine
eClinicalMedicine
Zegocractin for acute pancreatitis with systemic inflammatory response syndrome: a randomized, controlled, dose-ranging, phase 2b trial [0.03%]
泽高奥克雷汀治疗全身炎症反应综合征急性胰腺炎的疗效和安全性Ⅱb期随机对照剂量范围试验
Robert Sutton,Pramod K Garg,Joseph Miller et al.
Robert Sutton et al.
Background: Acute pancreatitis (AP) is without specific drug therapy. We conducted a phase 2b trial of the calcium release-activated calcium channel inhibitor zegocractin, previously found to accelerate recovery of food i...
COVID-19 vaccination status during pregnancy and preeclampsia risk: the pandemic-era cohort of the INTERCOVID consortium [0.03%]
新冠疫苗接种与妊娠期子痫前期风险的关系：INTERCOVID联盟大流行病时期的队列研究
Paolo Ivo Cavoretto,Jose Villar,Antonio Farina et al.
Paolo Ivo Cavoretto et al.
Background: We tested whether COVID-19 vaccination affects the risk of preeclampsia (PE) given the well-documented association between COVID-19 and PE, and their overlapping risk factors and pathophysiological pathways. ...
Use of pre-operative blood products in abdominal trauma: a planned secondary analysis of the GOAL-trauma study [0.03%]
术前血液制品在腹部创伤中的使用：GOAL-创伤研究的计划性二次分析
Wee-Han Ng,Michael F Bath,Joachim Amoako et al.
Wee-Han Ng et al.
Background: Haemorrhage remains the leading cause of death in patients with abdominal trauma. However, variation remains globally in the standards of transfusion practice. The aim of this study was to characterise global ...
A predictive, multi-source, attack-level model to quantify and characterize the injury burden and need for reconstructive surgery in Gaza [0.03%]
一个预测的、多来源的攻击级别模型，用于量化和表征加沙地带受伤负担及整形外科手术需求
Pranav N Haravu,Elaine Lin,Oumaima Berrada et al.
Pranav N Haravu et al.
Background: Since October 2023, the war in Gaza has produced a massive Palestinian civilian injury burden and created a large need for reconstructive surgery. It has also crippled an already fragile healthcare system and ...
Development of an early prediction model for endometriosis risk: the simplified adolescent factors for endometriosis (SAFE) score [0.03%]
青少年子宫内膜异位症发病风险简易预测模型的建立——SAFE评分系统
Gita D Mishra,Mohammad Reza Baneshi,Sally Mortlock et al.
Gita D Mishra et al.
Background: Endometriosis affects 11% of women of reproductive age. Diagnosis is often delayed by 6-8 years due to nonspecific symptoms and lack of early detection tools. This study aimed to develop an early risk predicti...