Tocotrienol-rich vitamin E complex in CADASIL (T3CAD): a randomised, double-blind, placebo-controlled trial [0.03%]
Hugues Chabriat,Lucie Biard,Stéphanie Guey et al.
Hugues Chabriat et al.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic small vessel disease, causing recurrent stroke and progressive cognitive declin...
Economic evaluations of outpatient stroke rehabilitation models: a systematic review of evidence, methods, and gaps [0.03%]
Ahmad Al Miaraj,Sonila M Tomini,Nick Ward et al.
Ahmad Al Miaraj et al.
Background: Stroke imposes an ongoing burden on patients and health systems, making outpatient rehabilitation essential. The economic efficiency of alternative outpatient models remains uncertain, complicating resource al...
Sex ratio disparities in the two most common cancers worldwide: an exploratory analysis using GLOBOCAN 2022 data, gender inequalities, and economic indicators [0.03%]
Amalia Martinez,Léna Bonin,Pascale Grosclaude et al.
Amalia Martinez et al.
Background: Lung and colorectal cancers are the most common non-sex-specific cancers worldwide and represent a major share of global incidence and mortality. Although international variations in incidence are well documen...
Nitrous oxide for late-life depression with inadequate antidepressant response: a randomised controlled trial [0.03%]
Antony Salamé,Samuel Bulteau,Gabriel Robert et al.
Antony Salamé et al.
Background: Late-life depression with inadequate antidepressant response is a pressing clinical issue with limited proven therapies. Nitrous oxide (N2O) may offer a new therapeutic avenue with rapid and safe antidepressan...
High-end intestinal ultrasound versus mid-end systems benchmarked against tandem ileocolonoscopy in inflammatory bowel disease (HUMID): a paired prospective, validating confirmatory study [0.03%]
高质量肠道超声与中端系统联合肠镜在炎症性肠病中的对照研究(HUMID)：一项配对的、前瞻性的、验证性研究
Partha Pal,Mohammad Abdul Mateen,Syed Misba Naaz et al.
Partha Pal et al.
Background: Intestinal ultrasound (IUS) is redefining inflammatory bowel disease (IBD) monitoring, but global adoption remains limited by the cost of high-end systems. This study evaluated whether widely available mid-ran...
A histo-clinical score to predict evolution to radioactive iodine-refractory of the follicular cell-derived thyroid carcinoma (PREDIRAIR): a single-centre, prospective, cohort study [0.03%]
一项预测分化型甲状腺癌进展至碘治疗抵抗的评分系统（PREDIRAIR）：单中心前瞻性队列研究
Laurine Mebarki,Elise Andre,Fabien Subtil et al.
Laurine Mebarki et al.
Background: Radioiodine refractory (RAIR) non-anaplastic follicular-cells derived thyroid carcinomas (FCDTC), are responsible for most FCDTC mortality. Although early detection could enable personalised strategies, precis...
Impact of cisplatin dose, renal function, and other factors on audiometrically-assessed ototoxicity in more than 1400 adult-onset cancer survivors from The Platinum Study: a multicentre cohort study [0.03%]
顺铂剂量、肾功能和其他因素对超过1400例成年癌症幸存者听觉毒性的队列研究：一项多中心队列研究
Victoria A Sanchez,Paul C Dinh Jr,Patrick O Monahan et al.
Victoria A Sanchez et al.
Background: Cisplatin is broadly used, but it is nephrotoxic and ototoxic. No large-scale investigation has analysed cisplatin-related ototoxicity while considering quantified renal function, cumulative dose, comorbiditie...
A quasi-experimental effectiveness evaluation of a nurse-led Hospital Violence Intervention Programme in the United Kingdom using linked routine health and administrative data [0.03%]
基于常规医疗和行政数据的医院暴力干预计划——一项准实验有效性评估研究
Simon C Moore,Sinead Brophy,Amrita Bandyopadhyay et al.
Simon C Moore et al.
Background: Emergency Department (ED) care of people injured in violence is increasingly seen as an opportunity to address patients' psychosocial vulnerabilities as well as their treatment. These vulnerabilities include a...
Antipsychotic dose and efficacy for acute schizophrenia spectrum disorders: an updated systematic review and dose-response meta-analysis [0.03%]
抗精神病药物剂量与急性分裂症谱系障碍的疗效：系统回顾和剂量反应meta分析更新版
Yuki Furukawa,Xiao Lin,Alessandro Rodolico et al.
Yuki Furukawa et al.
Background: The optimal antipsychotic doses for achieving efficacy in acute schizophrenia spectrum disorders have been investigated but uncertainties remained. We conducted one-stage dose-response meta-analyses to elucida...
Locally advanced rectal cancer: what patients and practitioners should know about non-operative management [0.03%]
局部晚期直肠癌：患者和医务人员需要了解的非手术治疗方法
Federica Tosi,Giorgio Patelli,Pietro Carnevali et al.
Federica Tosi et al.
For decades, the standard of care for locally advanced rectal cancer (LARC) has consisted of rectal surgery combined with chemoradiotherapy, saving many lives but often impairing long-term quality of life. Recently, emerging evidence shows ...