GLP-1 receptor agonist and risk of erectile dysfunction in men with type 2 diabetes: a target trial emulation [0.03%]
Huilin Tang,Yiwen Lu,Bingyu Zhang et al.
Huilin Tang et al.
Background: The association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and the risk of erectile dysfunction (ED) in men with type 2 diabetes (T2D) remains unclear. This study aimed to evaluate the risk o...
Concordance and prognostic value of bone-marrow MRD and PET-CT in multiple myeloma: a systematic review and meta-analysis [0.03%]
Max Mendez-Lopez,Marco Talarico,Christoph Driessen
Max Mendez-Lopez
Background: Bone-marrow minimal residual disease (MRD) and positron emission tomography/computed tomography (PET-CT) are central to response assessment in multiple myeloma (MM); however, their agreement, discordant patter...
Digital illiteracy and access to remote patient monitoring in oncology: a multicentre study of healthcare providers' perceptions and patient-reported digital literacy [0.03%]
Eléna Prospero,Alexandre Yazigi,Roman Rouzier et al.
Eléna Prospero et al.
Background: Remote patient monitoring (RPM) through electronic patient-reported outcomes (ePROs) has been shown to improve symptom management, treatment adherence, and quality of care in oncology. Despite these benefits, ...
Tiantian Zhang,Qingshuang Wei,Nora Schmit
Tiantian Zhang
Background: Nipah virus was first detected in the 1998-1999 Malaysia outbreak and remains a significant public health concern due to its high epidemic potential and recurrent outbreaks in South Asia. Incidence patterns of...
Integrating clinical decision support and mobile health for differentiated HIV service delivery in Lesotho (VITAL): a cluster-randomised non-inferiority trial [0.03%]
Nadine Tschumi,Malebanye Lerotholi,Mathebe Kopo et al.
Nadine Tschumi et al.
Background: The World Health Organization conditionally endorses digital interventions to strengthen health systems, while acknowledging limited evidence on their benefits and harms. We assessed the effectiveness of digit...
Evaluating the basis for use of advanced stage as a surrogate endpoint for cancer mortality in screening trials: a simulation study of meta-correlation and an alternative framework [0.03%]
Peter D Sasieni,Adam R Brentnall,Stephen W Duffy
Peter D Sasieni
Background: Surrogate endpoints have been proposed to accelerate the evaluation of cancer screening but are controversial. Recent systematic reviews of advanced stage and cancer mortality in randomised trials of cancer sc...
Challenges in early detection and prognostication of sepsis: new approaches from the emergency department and intensive care unit [0.03%]
Thomas Lafon,Melanie Weingart,Julien Vaidie et al.
Thomas Lafon et al.
In this narrative review, we aimed to provide a comprehensive overview of emerging diagnostic strategies and precision medicine approaches in sepsis, while explicitly acknowledging the heterogeneity of clinical contexts. In the Emergency De...
Population health and implementation outcomes of self-testing for SARS-CoV-2 using antigen detecting diagnostics: a systematic review and meta-analysis [0.03%]
Lukas E Brümmer,Verena Faehling,Sean McGrath et al.
Lukas E Brümmer et al.
Background: COVID-19 antigen-based rapid diagnostic tests (Ag-RDTs) for self-testing (C19ST) have been widely implemented. However, evidence on population health and implementation outcomes remains limited. We systematica...
Assessing the feasibility of a co-produced peer-group intervention for supporting wellbeing during the transition to adulthood among autistic 16-25-year-olds (ATAG): a randomised controlled feasibility trial [0.03%]
Kate Cooper,Rachel A VanDaalen,Annabel Burnley et al.
Kate Cooper et al.
Background: Autistic people, including those without intellectual disability, face challenges during the transition to adulthood, and experience poor adult outcomes. We conducted a feasibility trial of a novel co-produced...
Intraoperative allogeneic packed red blood cell transfusions and postoperative delirium: a retrospective cohort study in the USA [0.03%]
Xiaohan Xu,Luca J Wachtendorf,Béla-Simon Paschold et al.
Xiaohan Xu et al.
Background: Delirium is a frequent and often detrimental postoperative complication that may be precipitated by perioperative inflammation. Packed red blood cell (PRBC) transfusions are important to maintain adequate oxyg...