Immune-based cancer therapies: mechanistic insights, clinical progress, and future directions [0.03%]
基于免疫的癌症疗法：机制见解、临床进展和未来方向
Mahalakshmi Devaraji,Binoy Varghese Cheriyan
Mahalakshmi Devaraji
The field of cancer immunotherapy has evolved rapidly, offering new treatment paradigms by harnessing the body's own immune system to target and destroy malignancies. Various immunotherapeutic approaches, including immune checkpoint inhibit...
The role of 3D culture models and advanced chromatography in exosome research for triple-negative breast cancer [0.03%]
三维培养模型和先进色谱技术在三阴性乳腺癌外泌体研究中的作用
Mujibullah Sheikh,Harpritkaur Bagga,Yukta Bhojwani et al.
Mujibullah Sheikh et al.
Triple-negative breast cancer (TNBC) is among the most difficult subtypes of breast cancer to treat and is characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression. Owing to its Limited molecular targets...
Factors influencing breast and cervical cancer screening among ever-married women aged 15-49 in Jordan: an analysis of the 2023 Jordan population and family health survey [0.03%]
约旦已婚女性乳腺癌和宫颈癌筛查影响因素分析：基于2023年约旦人口与家庭健康调查数据的研究
Rajat Das Gupta,Shuvajit Saha,Md Ataur Rahman et al.
Rajat Das Gupta et al.
Purpose: This study sought to investigate the prevalence and sociodemographic determinants related to breast and cervical cancer screening among ever-married women aged 15 to 49 years in Jordan. ...
Carnitine deficiency augments methotrexate-mediated acute renal injury in rats [0.03%]
左卡尼丁缺乏加重甲氨蝶呤致大鼠急性肾损伤
Fatema Alaa El-Din Selim,Mahmoud M Khattab,Abdel-Moneim M Osman et al.
Fatema Alaa El-Din Selim et al.
Background: This research aimed to explore if carnitine (CARN) deficiency is a risk factor in methotrexate (MTX)-mediated acute kidney injury (AKI) and to mechanistically reveal the potential attenuating effect of CARN ag...
De-escalating axillary surgery in node-positive early breast cancer patients undergoing primary surgery: current evidence and recommendations [0.03%]
腋窝淋巴结阳性的早期乳腺癌患者初次手术时降级腋窝手术的现有证据和建议
Hussain Abdulla,Eman Hamza,Maha Alsendi
Hussain Abdulla
Landmark trials have shown that axillary lymph node dissection (ALND) can be safely omitted in early breast cancer patients with 1-2 positive nodes. Despite lack of prospective data, the National Comprehensive Cancer Network (NCCN) guidelin...
Role of tumor microenvironment in cancer promotion, development of drug resistance and cancer treatment [0.03%]
肿瘤微环境在癌症发生发展、耐药及治疗中的作用
Duaa E Fathah,Samina Ejaz
Duaa E Fathah
Cancer is a multifactorial disease and the second leading cause of death worldwide after cardiovascular disease. Initially, it was considered a genetic disease or gene expression disorder, but now it is regarded as a tumor microenvironment ...
Prostate sparing radical cystectomy and neobladder: institutional long-standing qualified consideration [0.03%]
保留前列腺的根治性膀胱全切回肠导尿术：长期机构经验总结
Omaya Nassar,Iman Gouda Farahat
Omaya Nassar
Objectives: To balance the extended functional urinary voiding and morbidity outcomes amid Ileal W and Y-shaped contrasted to spherical ileocoecal (IC) orthotopic bladders subsequent prostate-sparing radical cystectomy (P...
Nested PCR detection of JC polyomavirus large T-antigen in prostate cancer tissues: a case-control analysis in a Sudanese population [0.03%]
苏丹人群中前列腺癌组织中JC多瘤病毒大T抗原的嵌套PCR检测：一项病例对照分析研究
Maria Ahmed Mohamed Higair,Babbiker Mohammed Taher Gorish,Sana Eltahir Abdallah
Maria Ahmed Mohamed Higair
Background: The potential involvement of JC polyomavirus (JCPyV) in prostate cancer (PCa) remains a subject of debate, as existing in vitro studies have produced conflicting results. Understanding the viral oncogenic mech...
Clinical implementation of a multifaceted quality assurance phantom for high-precision radiation therapy: an institutional experience [0.03%]
一种高精度放射治疗质量保证多功能模体的临床应用及经验总结
Sandeep Singh,Abhay Kumar Singh,Dipesh et al.
Sandeep Singh et al.
Aim: This study aimed to evaluate the multifaceted clinical utility of the RUBY phantom as a comprehensive quality assurance (QA) platform in high-precision radiotherapy, particularly for stereotactic radiosurgery (SRS) a...
Exploring the therapeutic potential of scorpion venom to mitigate colorectal cancer biomarkers in rats [0.03%]
探究蝎毒通过下调结直肠癌标志物来治疗癌症的潜力研究
Wesam M Salama,Sara O Radwan,Elsayed I Salim
Wesam M Salama
Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. The limitations of conventional therapies, namely severe side effects and the emergence of drug resistance, underscore the urgent need for novel and ...