CRISPR-activated expression of collagen col-120 increases lifespan and heat tolerance [0.03%]
CRISPR激活COL-120的表达可提高寿命和耐热性
Anita Goyala,Collin Y Ewald
Anita Goyala
Transgenic overexpression of collagen col-120 increases the lifespan of C. elegans . However, whether post-developmental enhancement of collagen expression could also increase the lifespan is unknown. Recently, we described a method to indu...
No apparent role for the Wari insulator in transcriptional regulation of the endogenous white gene of Drosophila melanogaster [0.03%]
果蝇Wari绝缘子未见调节内源性white基因转录的作用
Gordian Born,Dimi Bieli,Mario Metzler et al.
Gordian Born et al.
Chromatin insulators have been proposed to play an important role in chromosome organization and local regulatory interactions. In Drosophila , one of these insulators is known as Wari. It is located immediately downstream of the 3' end of ...
A narrow gene encoding an extracellular matrix is involved in the formation of the footpad hairs in Drosophila melanogaster [0.03%]
一个编码细胞外基质的狭小基因参与果蝇(Drosophila melanogaster)足垫毛的形成
Kohei Tanaka,Ryunosuke Minami,Ken-Ichi Kimura
Kohei Tanaka
Drosophila melanogaster is an insect that can walk on smooth surfaces, and its tarsal segments bear a pair of footpads that are equipped with spatulate-shaped hairs (setae). We found that narrow B ( nw B ) mutants, an allele of the nw gene,...
Collagen9a1c localizes to collagen fibers called actinotrichia in zebrafish fins [0.03%]
斑马鱼鳍中的胶原蛋白9A1C定位于称为肌动纤毛的胶原纤维上
Hibiki Nakagawa,Toshihiro Aramaki,Shigeru Kondo et al.
Hibiki Nakagawa et al.
Teleost fish fins are supported by spear-shaped collagen crystals called actinotrichia. Actinotrichia are distributed radially at the distal end of the fins and thought to be necessary for proper formation of the fin and fin-bones. We previ...
The effect of ice-binding proteins on the cryopreservation of Caenorhabditis elegans [0.03%]
冰结合蛋白对秀丽隐杆线虫冷冻保存的影响
Masahiro Kuramochi,Tatsuya Arai,Kazuhiro Mio et al.
Masahiro Kuramochi et al.
Ice-binding proteins (IBPs) are capable of binding ice crystals and inhibiting their growth. IBPs have also been reported to stabilize cell membranes under non-freezing conditions. The effects of IBPs help to reduce cold- and freezing-induc...
The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan [0.03%]
芽孢杆菌对秀丽隐杆线虫寿命的有益影响及丝氨醇糖基转移酶的作用机制研究
Chelsey L Arvin,Zachary Sibila,Regina Lamendella et al.
Chelsey L Arvin et al.
Ceramide glucosyltransferase (CGT) adds sugar moieties to ceramide, forming glucosylceramides that play roles in immune signaling, stress response, and host-bacterial interactions. Here, we examined whether mutations in cgt block the benefi...
C. elegans dkf-1 (Protein Kinase D1) mutants have age-dependent defects in locomotion and neuromuscular transmission [0.03%]
秀丽隐杆线虫蛋白激酶D1突变体的年龄依赖性运动和神经肌肉传递缺陷
James R Johnson,Jeff W Barclay
James R Johnson
Changes in neuronal function that occur with age are an area of increasing importance. A potential significant contributor to age-dependent decline may be alterations to neurotransmitter release. Protein kinases, such as Protein Kinase C an...
Characterizing Three Azides for Their Potential Use as C. elegans Anesthetics [0.03%]
三种叠氮化合物使秀丽隐杆线虫麻醉的效果研究
Shasha Tu,Jiangyun Li,Kui Zhang et al.
Shasha Tu et al.
Sodium azide (NaN 3 ) is widely used as an anesthetic in the C. elegans community for studying animal behavior. It is not known whether other azides can function as anesthetics. This is quite important for the C. elegans labs in which NaN 3...
Rearing C. elegans on Parafilm-wrapped NGM Plates Impacts Habituation Behavior [0.03%]
在包裹了Parafilm的NGM培养基平板上饲养C. elegans会影响其习惯化行为
Jessica Chalissery,Isabel Wilson,Catharine Rankin et al.
Jessica Chalissery et al.
Scientists use Parafilm to seal Caenorhabditis elegans cultures on Nematode Growth Media (NGM) petri plates for short-term storage to reduce the likelihood of contamination and improve moisture retention. However, we found that maintaining ...
Low-dose N-acetyl cysteine prevents paraquat-induced mortality in Caenorhabditis elegans [0.03%]
低剂量N-乙酰半胱氨酸通过预防美洲齿翼虫(PAW)引起的致死作用来防治百草枯中毒
Candelaria Gonzales-Moreno,Lucia E Fernandez-Hubeid,Andrea Holgado et al.
Candelaria Gonzales-Moreno et al.
Exposure to the herbicide paraquat (PQ; 1,1'-dimethyl-4,4'-bipyridinium dichloride) affects the redox balance of the cell, an effect that can be restored by antioxidants, including N-acetyl cysteine (NAC). One hour of exposure to PQ (0 mM, ...