Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs motor function [0.03%]
秀丽隐杆线虫神经元中hTDP-43过度表达影响运动功能
Mandy Koopman,Lale Güngördü,Renée I Seinstra et al.
Mandy Koopman et al.
Transactive response DNA binding-protein 43 (TDP-43) is a conserved RNA/DNA-binding protein with a role in RNA metabolism and homeostasis. Aberrant TDP-43 functioning has been considered a major culprit in amyotrophic lateral sclerosis (ALS...
Neuronal overexpression of hTDP-43 in Caenorhabditis elegans mimics the cellular pathology commonly observed in TDP-43 proteinopathies [0.03%]
秀丽隐杆线虫神经元内hTDP-43过度表达可模拟TDP-43蛋白病常见的细胞病理变化
Mandy Koopman,Lale Güngördü,Renée I Seinstra et al.
Mandy Koopman et al.
Inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a characteristic feature of amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans has been instrumental in studying the underlying mechanisms of TDP-43 ...
A ubiquitin fusion reporter to monitor muscle proteostasis in C. elegans [0.03%]
一种用于监测秀丽隐杆线虫肌肉蛋白稳态的泛素融合报告基因
Carl Elias Kutzner,Karen Carolyn Bauer,Thorsten Hoppe
Carl Elias Kutzner
Muscle is a highly dynamic tissue in which a variety of folding and degradation processes are active to maintain protein homeostasis (proteostasis) and functionality. The muscle-specific chaperone UNC-45 folds the motor protein myosin and a...
rrvgo: a Bioconductor package for interpreting lists of Gene Ontology terms [0.03%]
rrvgo：一个用于解释基因本体论术语列表的Bioconductor包
Sergi Sayols
Sergi Sayols
Gene Ontology (GO) annotation is often used to guide the biological interpretation of high-throughput omics experiments, e.g. by analysing lists of differentially regulated genes for enriched GO terms. Due to the hierarchical nature of GOs,...
Neuronal overexpression of hTDP-43 in Caenorhabditis elegans impairs different neuronally controlled behaviors and decreases fecundity [0.03%]
人源化TDP-43在秀丽隐杆线虫中的神经元过表达损伤多种受神经元控制的行为并降低繁殖力
Mandy Koopman,Lale Güngördü,Renée I Seinstra et al.
Mandy Koopman et al.
Cytoplasmic inclusions consisting of transactive response DNA-binding protein 43 (TDP-43) are a key hallmark of TDP-43 proteinopathies like amyotrophic lateral sclerosis (ALS). Caenorhabditis elegans is considered a useful model for studyin...
Characterization of a novel sRNA contributing to biofilm formation in Salmonella enterica serovar Typhimurium [0.03%]
参与沙门氏菌生物被膜形成的新型sRNA的特征分析研究
Sayema Naaz,Najmuj Sakib,Dominika Houserova et al.
Sayema Naaz et al.
Small RNAs (sRNAs) are short noncoding RNAs of ~50-200 nucleotides believed to primarily function in regulating crucial activities in bacteria during periods of cellular stress. This study examined the relevance of specific sRNAs on biofilm...
Neuronal overexpression of human TDP-43 in Caenorhabditis elegans causes a range of sensorimotor phenotypes [0.03%]
人TDP-43在秀丽隐杆线虫中的神经元过表达引起多种感觉运动缺陷
Mandy Koopman,Lale Güngördü,Renée I Seinstra et al.
Mandy Koopman et al.
CURLY LEAF is required for the auxin-dependent regulation of 3-dimensional growth specification in Physcomitrium patens [0.03%]
卷曲叶基因参与拟南芥细弱ensis三维生长的调控
Rency J Raquid,Richard Jaeger,Laura A Moody
Rency J Raquid
The no gametophores 4 ( nog4-R ) mutant cannot make the transition from 2-dimensional (2D) to 3-dimensional (3D) growth in Physcomitrium patens and forms side branch initials that are largely fated to become sporophyte-like structures. We d...
Neogenin expression in ependymo-radial glia of the larval sea lamprey Petromyzon marinus spinal cord [0.03%]
七鳃鳗脊髓ependymo-放射状胶质细胞中新生蛋白的表达
Laura González-Llera,Michael I Shifman,Antón Barreiro-Iglesias
Laura González-Llera
Neogenin is a receptor mainly known for its roles during axon pathfinding. However, neogenin is expressed in neuronal precursors of ventricular and subventricular zones of the nervous system and recent work has shown that it regulates adult...
Minitraps: A simple, compact, low-cost, and reusable method for collecting soil nematodes [0.03%]
微型陷阱：一种简单、紧凑、低成本且可重复使用的采集土壤线虫的方法
Rebekah J White,Lara Oliveira Clemente
Rebekah J White
Soil organisms are a crucial part of the terrestrial biosphere and are essential for ecosystem functioning. A major part of soil and sediment ecosystems are nematodes worms, which can be used as a bioindicator of soil status. These worms re...