Isoform specific knockdown of the ETS transcription factor Pointed in Drosophila S2 cells [0.03%]
用RNAi敲低果蝇S2细胞中ETS转录因子Pnt的异构体
Pavithra Vivekanand
Pavithra Vivekanand
Alternate splicing of the pointed ( pnt ) gene locus produces two major isoforms, PntP1 and PntP2. Understanding their individual contributions to key developmental processes and identification of their genome-wide transcriptional targets h...
Hiu Tung Chow,Rebecca A Mosher
Hiu Tung Chow
Petal color is an important trait for both ornamental purposes and also for attracting pollinators. Here, we report a mutation of Brassica rapa R-o-18 with pale yellow petals that we retrieved from an EMS population and named whiter shade o...
The C. elegans deglutamylase CCPP-6 does not operate redundantly with CCPP-1 in gross cilia integrity [0.03%]
CCPP-6谷氨酰胺肽酶不是秀丽隐杆线虫纤毛完整性的冗余调节因子
Abigail S Klimas,Jessica Dominguez,Bhumi P Shah et al.
Abigail S Klimas et al.
Tubulin glutamylation is a reversible modification of the microtubules that regulates cilia stability and function. The addition of glutamates to the microtubule is catalyzed by members of the TTLL family of enzymes, while the removal is ca...
A QTL on chromosome IV explains a natural variation of QR.pap final position in Caenorhabditis elegans [0.03%]
一个位于IV号染色体的QTL可以解释Caenorhabditis elegans中QR.pap最终位置的自然差异
Clément Dubois,Marie-Anne Félix
Clément Dubois
In Caenorhabditis elegans , the QR neuroblast and its progeny migrate from the posterior to the anterior part of the animal during the L1 stage. We previously showed that the final position of QR.pa daughters varies among C. elegans wild is...
Aldh1l1-Cre/ER T2 is expressed in unintended cell types of the salivary gland, pancreas, and spleen [0.03%]
Aldh1l1-Cre/ER T2 在意外的唾液腺、胰腺和脾细胞类型中表达
Daniel Nemeth,Numana Luqman,Loretta Chen et al.
Daniel Nemeth et al.
The Aldh1l1-Cre/ER T2 mouse is a widely used transgenic mouse model to conditionally express Cre recombinase in astrocytes of the central nervous system. Currently, no reports show whether the Cre recombinase activity, driven by the Aldh1l1...
Pol V produced RNA facilitates transposable element excision site repair in Arabidopsis [0.03%]
拟南芥POL V介导的RNA促进转座子切除位点的修复
Kaili Renken,Sarah M Mendoza,Stephanie Diaz et al.
Kaili Renken et al.
The plant-specific RNA Polymerase V (Pol V) plays a key role in gene silencing, but its role in repair of double stranded DNA breaks is unclear. Excision of the transposable element mPing creates double stranded breaks that are repaired by ...
APEX2-Mediated Proximity Labeling of Wnt Receptor Interactors Upon Pathway Activation [0.03%]
通路激活过程中APEX2介导的Wnt受体相互作用蛋白邻近标记研究
Ellen Youngsoo Rim,Roeland Nusse
Ellen Youngsoo Rim
The Wnt signaling pathway regulates metazoan development, tissue homeostasis, and regeneration. Many outstanding questions in Wnt signal transduction revolve around the molecular events immediately following Wnt-receptor interactions. To id...
Haldol Targets IQGAP1 Pathway and Promotes Novel Partner Interactions in Glioblastoma Cell Lines [0.03%]
haloperidol通过靶向IQGAP1通路并促进新的相互作用来诱导胶质母细胞瘤细胞系中的铁死亡
Varun J Iyer,Mahasin A Osman
Varun J Iyer
Glioblastoma multiform (GBM) is an incurable heterogenous brain cancer with few clinical target options. IQGAP1 is a scaffold oncoprotein involved in GBM with unclear mechanism. Here we report that the antipsychotic drug Haldol differential...
Screening fungal strains isolated from a limestone cave on their ability to grow and precipitate CaCO 3 in an environment relevant to concrete [0.03%]
从石灰岩洞中分离出的产孢子真菌筛选其在与混凝土相关环境中生长和沉淀碳酸钙的能力
Aurélie Van Wylick,Simon Vandersanden,Karl Jonckheere et al.
Aurélie Van Wylick et al.
Fungi-mediated self-healing concrete is a novel approach that promotes the precipitation of calcium carbonate (CaCO 3 ) on fungal hyphae to heal the cracks in concrete. In this study, we set out to explore the potential of fungal species is...
The Antipsychotic Drug Haldol Modulates IQGAP1-Signaling and Inhibits Cell Proliferation in Triple Negative Breast Cancer Cell Lines [0.03%]
精神分裂症用药Haldol调节IQGAP1信号并抑制三阴性乳腺癌细胞的增殖
Varun J Iyer,Mahasin A Osman
Varun J Iyer
The signaling scaffold oncoprotein IQGAP1 was identified as a classification and therapeutic biomarker in triple negative breast cancer (TNBC) cell lines. Here, we report that the antipsychotic drug Haldol induces novel protein-protein inte...