Human YRNA 4 (HY4) plasma levels are a prognostic indicator of SARS-CoV-2 infection clinical severity [0.03%]
人YRNA 4(HY4)血液水平是预测SARS-CoV-2感染临床严重性的预后指标
Nathaniel S Olliff,Miles A Hunt,Sunita S Paudel et al.
Nathaniel S Olliff et al.
SARS-CoV-2 infection can result in a range of outcomes from asymptomatic/mild disease to severe COVID-19/fatality. In this study, we investigated the differential expression of small noncoding RNAs (sncRNAs) between patient cohorts defined ...
Expression and cilia associated localization of Histone deacetylases 6 in Xenopus [0.03%]
非洲爪蟾组蛋白去乙酰酶6的表达及细胞内定位研究
Matthias Tisler,Tim Ott,Martin Blum et al.
Matthias Tisler et al.
Histone deacetylases (HDACs) are key posttranslational modulators of the proteome. We show that expression of histone deacetylase 6 ( hdac6 ) is dynamic and appears in a tissue specific manner throughout embryonic development of the frog Xe...
Homeotic transformations suggest mechanisms for rapid evolution diversification in Drosophila sex combs [0.03%]
同源异形转变提示了果蝇性梳快速进化的机制和多样化起源
Dawson Doucet,Nathan Friesen,Naomi Derksen et al.
Dawson Doucet et al.
Evolutionary innovations refer to the emergence of new traits, functions, or behaviors in organisms and lineages over time. Although research has demonstrated that such innovations can arise gradually or through small steps (Chouard 2010), ...
Isolation of mutant alleles of the U6 snRNA m 6 A methyltransferase Mtl16 and characterization of their genetic interactions with splicing mutants in Schizosaccharomyces pombe [0.03%]
麦胚囊转移RNA(m~6A)甲基转移酶Mtl16突变等位基因的分离及其与裂殖酵母(Schizosaccharomycespombe)剪接突变株间遗传互作的分析
Alaina H Willet,Liping Ren,Lesley A Turner et al.
Alaina H Willet et al.
Schizosaccharomyces pombe Dim1 is a conserved essential component of the U4/U6.U5 tri-snRNP complex essential for pre-mRNA splicing. In a synthetic lethal screen with the temperature-sensitive dim1-35 mutant, we isolated multiple alleles of...
A frameshift variant in the melanophilin gene is associated with loss of pigment from shed skin in ball pythons ( Python regius ) [0.03%]
蛇色素细胞素基因的一个无义突变与皮下色素丧失相关
Izabella Lederer,Basmah Shahid,Uyen Dao et al.
Izabella Lederer et al.
Melanophilin is a myosin adaptor required for transporting the pigment melanin within cells. Loss of melanophilin in fish, birds, and mammals causes pigmentation defects, but little is known about the role of melanophilin in non-avian repti...
APJ expression is lost in isolated embryonic coronary endothelial cell culture in vitro [0.03%]
APJ在体外分离的胚胎冠状内皮细胞培养过程中的缺失
Bryce Kuschel,Bikram Sharma
Bryce Kuschel
Coronary artery disease is one of the leading causes of death worldwide, and yet we lack the appropriate therapeutic treatments for it. Investigation into the mechanisms of coronary vessel development can provide insights into potential the...
Identification and sequencing of temperature sensitive alleles of the Anaphase Promoting Complex component mat-3 in C. elegans [0.03%]
C. elegans 中APC组分mat-3的温度敏感等位基因的鉴定和测序
Katherine A Maniates,Yamei Zuo,Kendall Flanagan et al.
Katherine A Maniates et al.
The Anaphase Promoting Complex (APC) regulates the transition from metaphase to anaphase during cell division and is important to prevent defects in chromosome segregation. In a recent temperature sensitive genetic screen looking for furthe...
Muhammad Zaka Asif,Maci C Benveniste,Kyra D Chism et al.
Muhammad Zaka Asif et al.
Caenorhabditis elegans are free-living nematodes with a relatively short life cycle and a wealth of genomic information across multiple databases. Uridine diphosphate-glycosyltransferases (UGTs) are a family of enzymes involved in Phase II ...
The large extracellular loop is important for recruiting CD63 to exosomes [0.03%]
大型细胞外环对于募集CD63到外泌体是重要的
Daniel Ivanusic,Joachim Denner
Daniel Ivanusic
Exosomes are small extracellular vesicles that are secreted from cells. To characterize exosome fraction marker proteins of the tetraspanin family in particular, CD9, CD63, and CD81 are routinely used. CD63 expression constructs were employ...
Expression of Drosophila VDRC GD RNAi lines in larval skeletal muscle often leads to abnormal proteostasis [0.03%]
果蝇VDRCGDRNAi系在幼虫骨骼肌中的表达常导致异常的蛋白质稳态
Myung-Jun Kim,Michael B O&#x;Connor
Myung-Jun Kim
In Drosophila , multiple transgenic RNAi libraries have been generated to facilitate large-scale genetic screens in vivo . Although those libraries have helped generate many new discoveries, certain libraries are associated with technical d...