Analysis of the Salmonella enterica serovar Typhimurium Chitobiose ( chb ) Operon [0.03%]
鼠伤寒沙门菌半乳糖生物素标记的碳源诱导的chb operon的表达受三种调控机制的影响
Kristin Hobson,Melanie Higgins
Kristin Hobson
Salmonella enterica serovar Typhimurium ( S. Typhimurium) is an intracellular pathogen that employs specialized virulence factors to survive and replicate within host cells, including a putative chitobiose ( chb) operon traditionally associ...
Resolving METTL5 Specificity: Direct RNA Sequencing Reveals No Compelling Evidence for METTL5 mediated mRNA m6A Methylation in mESCs [0.03%]
METTL5的特异性分析：直接RNA测序未在mES细胞中发现由METTL5介导的mRNA上发生m6A甲基化的确切证据
Samuel Le Cam,Magdalena Valenta,Robert Schneider
Samuel Le Cam
The methyltransferase-like 5 (METTL5) protein has been shown to catalyze m6A deposition on 18S ribosomal RNA. However, whether it also methylates mRNAs remains unclear. To address this, we employed direct RNA sequencing (ONT) for m6A detect...
Development and Optimization of CRISPR/Cas9-Assisted Recombineering in Escherichia albertii [0.03%]
大肠杆菌爱德华氏菌CRISPR/Cas9辅助重组技术的开发与优化
Shahab Ahmad Khan,Tara Marie Miller,Shantanu Bhatt et al.
Shahab Ahmad Khan et al.
Escherichia albertii is a zoonotic pathogen frequently misidentified as diarrheagenic E. coli due to shared phenotypic and genetic traits, yet functional genomic studies in this species have been limited by the inefficiency of traditional g...
Sodium chloride stress inhibits Saccharomyces paradoxus meiosis [0.03%]
钠氯胁迫抑制Saccharomyces paradoxus减数分裂
Gemima Germain,Sylvia Lamphere,Ella Molinari et al.
Gemima Germain et al.
Meiosis is a common response to nutrient deprivation in yeasts. Our goal was to determine whether the yeast Saccharomyces paradoxus performed meiosis under other abiotic stress factors, specifically salt stress. We predicted that S. paradox...
Lactate Dehydrogenase B Expression in Cerebellum of Adult Ube3a m-/p+ Mice [0.03%]
成人Ube3a m-/p+小鼠小脑中乳酸脱氢酶B的表达
Miriam Arlene Ramos Rivera,Ceidy Torres Ortiz
Miriam Arlene Ramos Rivera
Angelman syndrome (AS) is a neurodevelopmental disorder caused by the loss of the maternal allele of the UBE3A gene, which encodes a protein essential for ubiquitin-mediated protein degradation. AS mouse models exhibit elevated lactate and ...
The Functional Role of S280 within the ZYG-1 Phosphorylation Cluster During Centrosome Assembly in C. elegans Embryos [0.03%]
秀丽新链霉菌胚胎中S280在中心粒组装过程中参与ZYG-1磷酸化簇的的功能作用
Amber Christian,Sariah Richardson,Layanne Obeid et al.
Amber Christian et al.
Proper centrosome duplication requires precise regulation of ZYG-1 . CK2-mediated phosphorylation of ZYG-1 contributes to this process by controlling ZYG-1 stability and centrosome number. Previous work identified a cluster of serine residu...
Cmp7-dependent recruitment of Alx1 to a mitotic nuclear envelope hole in Schizosaccharomyces pombe [0.03%]
芽殖酵母中Cms7依赖的Alx1招募到一个有丝分裂核被膜孔道中
Kaela D Genereux,Olivia N Walker,Sage O Benders et al.
Kaela D Genereux et al.
The nuclear envelope maintains nucleocytoplasmic compartmentalization. Divergent strategies exist to accommodate the nuclear envelope during mitotic chromatin segregation. While the endosomal sorting complexes required for transport (ESCRT)...
TEAD inhibitors synergize with MEK, SHP2 and mTOR inhibitors in NF1 and NF2 cell lines [0.03%]
TEAD抑制剂与MEK、SHP2和mTOR抑制剂在NF1和NF2细胞系中协同作用
Yang Yang,Sharavana Gurunathan,Shane Schechter et al.
Yang Yang et al.
Neurofibromatosis type 1 (NF1) and NF2 -related Schwannomatosis ( NF2 -SWN) are both inherited syndromes characterized by Schwann cell tumors. NF1 tumors harbor activated Ras/MEK/ERK, while NF2 -SWN tumors harbor activated mechanosignaling ...
Grant Archer,Sam Bartlowe,Bilegtugs Bayarbadrakh et al.
Grant Archer et al.
We identify an endoderm-restricted organelle in published volume electron microscopy datasets of C. elegans embryos. The organelle consists of a tubular ring surrounding a membrane-bound compartment harboring a prominent densely stained par...
Caitlyn L Perry,Charles Robin
Caitlyn L Perry
The CYP307 enzymes are necessary for the synthesis of the arthropod ecdysteroid moulting hormones, but show a notably elevated duplication and loss rate compared to other enzymes acting in the same pathway. We demonstrate that Drosophila me...